The Mouse in Biomedical Research

Normative Biology, Husbandry, and Models Volume 3
2. Auflage 2006
ISBN: 978-0-12-369457-7
Verlag: Elsevier Science

Buch, Englisch, 816 Seiten, Format (B × H): 220 mm x 284 mm, Gewicht: 2127 g

Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse's normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.

Zielgruppe

Veterinary and medical students, senior graduate, graduate students, post-docs, and researchers who utilize animals in biomedical research

Autoren/Hrsg.

Weitere Mitwirkende

Fox, James G.

Barthold, Stephen

Davisson, Muriel

Newcomer, Christian E.

Quimby, Fred W.

Smith, Abigail

Fachgebiete

• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Wirbeltiere (Vertebrata) Säugetiere (Mammalia) Meeres- und Süßwassersäuger
• Naturwissenschaften Biowissenschaften Biowissenschaften
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Wirbeltiere (Vertebrata) Säugetiere (Mammalia) Beuteltiere (Monotremen)
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Wirbeltiere (Vertebrata) Säugetiere (Mammalia) Primaten

Inhaltsverzeichnis

1: Gross Anatomy 2: Mouse Physiology 3: Reproductive Biology of the Laboratory Mouse 4: Endocrinology: Bone as a Target Tissue for Hormonal Regulation 5: Hematology of the Laboratory Mouse 6: Clinical Chemistry of the Laboratory Mouse

Management, Techniques, and Husbandry 7: Gnotobiotics 8: Management and Design: Breeding Facilities 9: Design and Management of Research Facilities for Mice 10: Nutrition 11: Health Delivery and Quality Assurance Programs for Mice 12: Environmental and Equipment Monitoring 13: Biomethodology and Surgical Techniques 14: In-Vivo Whole-Body Imaging of the Laboratory Mouse

Use of Mice in Biomedical Research 15: Behavioral Testing 16: Cardiovascular Disease: Mouse Models of Atherosclerosis 17: Convulsive Disorders 18: Eye Research 19: Genetic Analysis of Rodent Obesity and Diabetes 20: Mouse Models in Aging Research 21: Mouse Models of Inherited Human Neurodegenerative Disease 22: Mouse Skin Ectodermal Organs 23: Quality Control Testing of Biologics

Über Autor(innen)

Fox, James G.
Prof. James G. Fox obtained his Doctor of Veterinary Medicine at Colorado State University, Fort Collins, and, as an NIH postdoctoral fellow, received a Master of Science in Medical Microbiology at Stanford University. Dr. Fox is an adjunct professor at Tufts University School of Veterinary Medicine. He is a diplomate and a past president of the American College of Laboratory Animal Medicine, as well as a past president of the Massachusetts Society for Medical Research and the American Association of Veterinary Medical Colleges. Additionally, he has served as past chairman of the AAALAC Council and the NCCR/NIH Comparative Medicine Study Section. He is also an elected fellow of the Infectious Disease Society of America and the American Gastroenterological Association. He was recruited to MIT and created the Division of Comparative Medicine, which he directed from 1974 until 2021. As a faculty member in the MIT Department of Biological Engineering, Professor Fox received numerous scientific awards and was elected to the National Academy of Medicine in 2004. Dr. Fox has been the principal investigator of an NIH postdoctoral training grant for veterinarians for 30 years and has trained 90 veterinarians for careers in biomedical research. The NIH has continuously funded him to study infectious diseases of the gastrointestinal tract, where he has studied the gastrointestinal microbiome and how it interfaces with and influences the host's immune response to gastrointestinal pathogens, particularly oncogenic Helicobacter species. He has authored over 600 papers, 84 chapters, holds 4 patents and has authored or edited 18 comparative medicine texts.