Thomas Fundamentals of Medicinal Chemistry

1. Auflage 2004
ISBN: 978-0-470-87169-0
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 302 Seiten, E-Book

Provides a concise introduction to the chemistry of therapeuticallyactive compounds, written in a readable and accessible style.
The title begins by reviewing the structures and nomenclature ofthe more common classes of naturally occurring compounds found inbiological organisms. An overview of medicinal chemistry isfollowed by chapters covering the discovery and design of drugs,pharmacokinetics and drug metabolism, The book concludes with achapter on organic synthesis, followed by a brief look at drugdevelopment from the research stage through to marketing the finalproduct.
The text assumes little in the way of prior biologicalknowledge. relevant biology is included through biological topics,examples and the Appendices.
* Incorporates summary sections, examples, applications andproblems
* Each chapter contains an additional summary section andsolutions to the questions are provided at the end of thetext
* Invaluable for undergraduates studying within the chemical,pharmaceutical and life sciences.

Autoren/Hrsg.

Thomas, Gareth

Inhaltsverzeichnis

Preface.
Acknowledgements.
Abbreviations/Acronyms.
1. Biological Molecules.
2. An Introduction to Drugs and Their Action.
3. An Introduction to Drug Discovery.
4. The SAR and QSAR Approaches to Drug Design.
5. Computer Aided Drug Design.
6. Combinatorial Chemistry.
7. Selected Examples of Drug Action at some Common TargetAreas.
8. Pharmacokinetics.
9. Drug Metabolism.
10. An Introduction to Lead and Analogue Syntheses.
11. Drug Development and Production.
Appendix 1. Sickle-cell Anaemia.
Appendix 2. Bacteria.
Appendix 3. Cell Membranes.
Appendix 4. Receptors.
Appendix 5. Transfer through Membranes.
Appendix 6. Regression Analysis.
Appendix 7. Enzymes.
Answers to Questions.
Selected Further Reading.
Index.