Thompson / Dews Advances in Behavioral Pharmacology

1. Auflage 2013
ISBN: 978-1-4832-1489-4
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 1, 278 Seiten, Web PDF

Reihe: Advances in Behavioral Pharmacology

Advances in Behavioral Pharmacology, Volume 1 provides synthetic and analytic reviews of significant areas of behavioral pharmacology, particularly the behavioral mechanisms of drug action. The book presents papers on the behavioral pharmacology of the tetrahydrocannabinols; on infrahuman ethanol self-administration; and on the discriminative stimulus properties of drugs. The text then describes various methods used to study the effects of drugs on discrimination; signal detection (SDT), which attempts to separate effects of variables on discrimination processes or capacity (sensitivity) from effects on the subject's criterion; and some of the uses of this model in behavioral pharmacology. The rate-dependency of the behavioral effects of amphetamine, as well as some of the major events in the history of behavioral pharmacology are also considered. The book concludes by tackling the status of behavioral pharmacology. Behavioral pharmacologists, pharmacologists, physicians, and students taking pharmacology and medicine will find the book useful.

Autoren/Hrsg.

Thompson, Travis

Dews, Peter B.

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Behavioral Pharmacology;4
3;Copyright Page;5
4;Table of Contents;6
5;List of Contributors;8
6;Preface;10
7;CHAPTER 1. BEHAVIORAL PHARMACOLOGY OF THE TETRAHYDROCANNABINOLS;12
7.1;I. Introduction;13
7.2;II. Difficulties in Studying the Behavioral Effects of Cannabis Preparations;13
7.3;III. Scope of the Present Review;17
7.4;IV. Effects of Tetrahydrocannabinols on Grossly Observable Behavior;19
7.5;V. Effects of Tetrahydrocannabinols on Schedule-Controlled Behavior;25
7.6;VI. Special Problems Concerning the Behavioral Effects of Tetrahydrocannabinols;37
7.7;VII. Concluding Statements;40
7.8;Acknowledgments;41
7.9;References;41
8;CHAPTER 2. ETHANOL SELF-ADMINISTRATION: INFRAHUMAN STUDIES;46
8.1;I. Introduction;47
8.2;II. Techniques Used in the Study of Ethanol Self-Administration;47
8.3;III. Establishment of Ethanol Intake;49
8.4;IV. Factors Affecting Ethanol Intake;53
8.5;V. Elimination of Ethanol Drinking;78
8.6;VI. Discussion;80
8.7;VII. Conclusions;81
8.8;References;82
9;CHAPTER 3. THE DISCRIMINATIVE STIMULUS PROPERTIES OF DRUGS;96
9.1;I. Introduction;97
9.2;II. Special Problems with Drugs as Stimuli;100
9.3;III. Drug Stimulus Control in the Absence of Discrimination Training;101
9.4;IV. Drugs as Discriminative Stimuli;106
9.5;V. Effectiveness of Drugs as Discriminative Stimuli;110
9.6;VI. Generalization;116
9.7;VII. Discriminability;124
9.8;VIII. Mechanisms of Drug Stimulus Control;128
9.9;IX. Drug Stimulus Control in Man;138
9.10;X. Nondrug Interoceptive Stimuli;140
9.11;XI. Implications of Drug Stimulus Control;142
9.12;References;145
10;CHAPTER 4. DRUGS, DISCRIMINATION, AND SIGNAL DETECTION THEORY;150
10.1;I. Introduction;151
10.2;II. Methods Used to Investigate Drug Effects on Discrimination;152
10.3;III. Signal Detection Theory;157
10.4;IV. Drug Effects;160
10.5;References;173
11;CHAPTER 5. RATE-DEPENDENCY OF THE BEHAVIORAL EFFECTS OF AMPHETAMINE;178
11.1;I. Introduction;178
11.2;II. General Statements on Rate-Dependency;180
11.3;III. Rate of Responding as a Dependent and Independent Variable;183
11.4;IV. Problems of Quantitation;184
11.5;V. Amphetamines in Rats;187
11.6;VI. Amphetamine in Squirrel Monkeys;209
11.7;VII. Amphetamine in Pigeons;217
11.8;VIII. Amphetamine in Mice;225
11.9;IX. General Comments on Points Which May Not Conform to Trend;228
11.10;X. Significance and Limitations of Analysis;231
11.11;XI. Conclusions;232
11.12;Acknowledgments;233
11.13;References;233
11.14;Note Added in Proof;238
12;CHAPTER 6. BEHAVIORAL PHARMACOLOGY: A BRIEF HISTORY;240
12.1;I. Introduction;241
12.2;II. Early Years;241
12.3;III. 1800–1940;243
12.4;IV. 1940–1955;244
12.5;V. 1955–Present;247
12.6;VI. Concepts Related to the Behavioral Actions of Drugs;256
12.7;VII. Current Developments;264
12.8;References;265
13;CHAPTER 7. CURRENT STATUS OF BEHAVIORAL PHARMACOLOGY;270
13.1;New Directions;273
13.2;References;274
14;SUBJECT INDEX;276