Thompson / Dews / McKim Advances in Behavioral Pharmacology

1. Auflage 2013
ISBN: 978-1-4832-1491-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 3, 234 Seiten, Web PDF

Reihe: Advances in Behavioral Pharmacology

Advances in Behavioral Pharmacology, Volume 3 covers papers dealing with various aspects of the ways in which drug effects are related to and perhaps modified by the rate of responding. The book discusses the behavioral actions of benzodiazepines and considers the extent to which these actions are consistent with the proposition that these effects are partially or entirely determined by control rates of responding. The text then describes rate-dependence and the effects of phenothiazine antipsychotics in pigeons; the rate-convergent effects of drugs; and the rate-dependent effects of extra stimuli, of drugs, and drug-state change. Historical, mathematical and alternative considerations in quantitation in behavioral pharmacology, as well as the history and status of rate-dependency investigations are also considered. The book then tackles the scope and limitations in the explanation and analysis of the behavioral effects of drugs; drug effects on behaviors maintained by different events; and the importance of identifying which of these factors contributes to the behavior studied in any given experiment. Pharmacologists, psychologists, psychiatrists, and students taking these disciplines will find the book useful.

Autoren/Hrsg.

Thompson, Travis

Dews, Peter B.

McKim, William A.

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Behavioral Pharmacology;4
3;Copyright Page ;5
4;Table of Contents;6
5;List of Contributors;10
6;Preface;12
7;Preface to the Ottawa Conference on the Rate-Dependent Effects of Drugs;14
8;Contents of Previous Volumes;16
9;Chapter 1. Rate-Dependence and the Effects of Benzodiazepines;18
9.1;I. Introduction;18
9.2;II. Effects of Benzodiazepines on Overall Rates of Responding Maintained by Different Schedules of Reinforcement;20
9.3;III. Effects of Benzodiazepines on Local Response Rates on Fixed-Interval Schedules;27
9.4;IV. Effects of Benzodiazepines on Punished Responding;32
9.5;V. Conclusions;35
9.6;References;35
10;Chapter 2. Rate-Dependence and the Effects of Phenothiazine Antipsychotics in Pigeons;38
10.1;I. Introduction;38
10.2;II. Effects of Phenothiazines on Multiple Fixed-Ratio, Fixed-Interval Performances;39
10.3;III. Effects of Phenothiazines on Shock-Avoidance Responding;42
10.4;IV. Effects of Phenothiazines on the Stimulus Control of Responding;47
10.5;V. Conclusions;52
10.6;References;54
11;Chapter 3. Rate-Convergent Effects of Drugs;56
11.1;I. Introduction: Rate-Dependency;56
11.2;II. Questions about Rate-Dependency;58
11.3;III. Problem: The Definition of Drug Effect;62
11.4;IV. Distributions of Rate-Dependency Slopes;63
11.5;V. Convergence of Rates;66
11.6;VI. Conclusions;73
11.7;References;74
12;Chapter 4. Rate-Dependency: A Nonspecific Behavioral Effect of Drugs;78
12.1;I. Introduction;78
12.2;II. Rate-Dependent Effects of Extra Stimuli;80
12.3;III. Rate-Dependent Effects of Drugs and Drug-State Change;84
12.4;IV. Duration of Rate-Dependent Changes Produced by Drugs and Stimuli;85
12.5;V. Effects of Varying the Intensity of ES and Dosage of Drug;87
12.6;VI. Type of Behavior Affected by Drugs and ES;88
12.7;VII. Conclusion;88
12.8;References;89
13;Chapter 5. Quantitation in Behavioral Pharmacology;92
13.1;I. Introduction;92
13.2;II. Historical Considerations;93
13.3;III. Mathematical Considerations;95
13.4;IV. Alternative Considerations;96
13.5;V. Conclusions;101
13.6;References;106
14;Chapter 6. Rate-Dependency: Scope and Limitations in the Explanation and Analysis of the Behavioral Effects of Drugs;108
14.1;I. Introduction;108
14.2;II. Response Rate and Other Influences on the Behavioral Effects of Drugs;109
14.3;III. Usefulness of Rate Analyses in Understanding the Actions of Drugs;115
14.4;IV. What Gets Changed When a Drug Alters Response Rates?;118
14.5;V. Conceptual Status of the Rate-Dependency Principle;123
14.6;VI. Conclusions;124
14.7;References;125
15;Chapter 7. History and Present Status of Rate-Dependency Investigations;128
15.1;Text;128
15.2;References;135
16;Chapter 8. Drug Effects on Behaviors Maintained by Different Events;136
16.1;I. Introduction;136
16.2;II. Early Studies;137
16.3;III. Characteristics of Behaviors Maintained by Different Events;141
16.4;IV. Comparisons of Drug Effects on Responding Maintained by Different Events;152
16.5;V. Summary and Conclusions;178
16.6;References;180
17;Chapter 9. Oral Self-Administration and the Relevance of Conditioned Taste Aversions;186
17.1;I. Introduction;187
17.2;II. Factors Maintaining Oral Self-Administration;188
17.3;III. Oral Self-Administration of Opioids;190
17.4;IV. Conditioned Taste Aversions Produced by Naloxone;195
17.5;V. Conditioned Taste Aversions Produced by Self-Administered Drugs;198
17.6;VI. Factors Influencing Amphetamine-Produced Taste Aversions;200
17.7;VII. Influence of Conditioned Taste Aversions on Operant Behavior;205
17.8;VIII. A Pharmacological Approach to Conditioned Taste Aversion;210
17.9;IX. Conditioned Anorexia Hypothesis of Taste Aversion;214
17.10;X. Duration of Drug Action and Conditioned Taste Aversion;218
17.11;XI. Summary and Conclusions;220
17.12;References;224
18;Index;232