Tipton Essays in Biochemistry

1. Auflage 2014
ISBN: 978-1-4832-6665-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 264 Seiten, Web PDF

Reihe: Essays in Biochemistry

Essays in Biochemistry, Volume 25 provides information on the developments in the continually changing field of biochemistry. Each chapter of the book is written by an expert on the area of research. The volume contains contributions that deal with such topics as intracellular protein degradation; the metabolic heterogeneity of liver parenchymal cells; and the biochemistry of ethanol metabolism and the pathogenesis of alcoholic liver disease (ALD). Biochemistry and neurochemistry in the 1800 and their origins in comparative animal chemistry is discussed extensively in the final chapter. Biochemists will find the book very informative.

Autoren/Hrsg.

Tipton, K. F.

Inhaltsverzeichnis

1;Front Cover;1
2;Essays in Biochemistry;4
3;Copyright Page;5
4;Table of Contents;12
5;Biography;6
6;Conventions;10
7;Preface;14
8;Chapter 1. Regulation of Intracellular Ca2+;16
8.1;I. Introduction;16
8.2;II. Measurement of Intracellular Ca2+;18
8.3;III. Stimuli Leading to Elevation of Cytosolic Ca2+;21
8.4;IV. Ca2+ Transport Systems;26
8.5;V. Integrated Systems;41
8.6;REFERENCES;47
9;Chapter 2. Intracellular Protein Degradation;54
9.1;I. Introduction;54
9.2;II. Measurement and Characteristics of Intracellular Protein Degradation;55
9.3;III. Substrate Proteins: Structure and Stability;62
9.4;IV. Degradation Systems;67
9.5;V. Proteolytic Enzymes and Inhibitors;75
9.6;VI. Regulation of Protein Turnover;85
9.7;VII. Concluding Remarks;88
9.8;ACKNOWLEDGEMENTS;88
9.9;REFERENCES;89
10;Chapter 3. Metabolic Heterogeneity of Liver Parenchymal Cells;98
10.1;I. Introduction;99
10.2;II. Vascular System of the Liver;101
10.3;III. The Periportal–Perivenous Gradient;107
10.4;IV. Development of Zonation;113
10.5;V. Separation of Periportal and Perivenous Hepatocytes;115
10.6;VI. Zonation of Major Metabolic Pathways;120
10.7;VII. Drug and Xenobiotic Metabolism;128
10.8;VIII. Zonation as a Regulatory Principle;134
10.9;REFERENCES;136
11;Chapter 4. Ethanol Metabolism and Alcoholic Liver Disease;152
11.1;I. Introduction;153
11.2;II. Metabolism of Ethanol;156
11.3;III. Pathogenic Mechanisms of Ethanol-induced Liver Damage;175
11.4;IV. Ethanol-induced Changes in Hepatic Structure and Function;191
11.5;V. Conclusions;194
11.6;REFERENCES;195
12;Chapter 5. Biochemistry and Neurochemistry in the 1800s: their Origins in Comparative Animal Chemistry;212
12.1;I. Introduction;212
12.2;II. Chemistry Within Natural History;213
12.3;III. Zoochemistry and Animal Chemistry from 1800;216
12.4;IV. Animal Chemistry of the 1840s;221
12.5;V. Comparative Animal Chemistry and Neurochemistry;225
12.6;VI. Physiological Chemistry and Biochemistry;229
12.7;VII. Discussion;232
12.8;VIII. Conclusions;235
12.9;ACKNOWLEDGEMENTS;236
12.10;REFERENCES;236
13;Subject Index;240
14;Cumulative Key Word Index;262