Touitou / Barry Enhancement in Drug Delivery

1. Auflage 2010
ISBN: 978-1-4200-0481-6
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 656 Seiten

Providing a significant cross-fertilization of ideas across several disciplines, Enhancement in Drug Delivery offers a unique comprehensive review of both theoretical and practical aspects of enhancement agents and techniques used for problematic administration routes. It presents an integrated evaluation of absorption enhancers and modes for promoting absorption that is especially valuable to those involved with the development of pharmaceutical, cosmetic, bioengineered, and medical products, as well as graduate students looking to study this intriguing field and those professionals involved with patents and regulatory issues. Organized by routes of administration, the book is divided into eight major sections: oral, rectal, buccal/sublingual, dermal/transdermal, nasal, vaginal/uterine, ocular, and brain. It offers fundamental as well specialized information including current findings on— · Surfactant use to accelerate macromolecule input · Targeted gastrointestinal delivery and enhanced absorption of lipophilic drugs · Permeation issues in rectal absorption · Chemical means of enhancement · Carriers for enhanced delivery to and across the skin · Methods associated with breaching the skin · Promoted buccal and sublingual absorption · Emerging ocular, nasal, vaginal, and uterine delivery systems · Carriers for overcoming the blood brain barrier Those investigators primarily involved with one specific route of delivery will be able to learn of helpful concepts and find additional stimulation from reading the approaches others have used within and outside their own spheres of activity. Readers are likely to find the same enhancer tested for various administration routes and in diverse experimental models. By understanding the properties and behavior of the enhancers operating within such systems, they may well find the inspiration needed to develop appropriate enhancing delivery methods for new applications.

Zielgruppe

Pharmaceutical scientists working in the design of new dosage forms,  industry and academic researchers, scientists involved with drug delivery, development, and testing (including clinical trials), and FDA regulatory personnel.

Autoren/Hrsg.

Touitou, Elka

Barry, Brian W.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Promoted Gastrointestinal Drug Absorption

Gastrointestinal Anatomy, Physiology and Permeation Pathways; Abraham Rubinstein

Enhancers for Enteral Delivery of Macromolecules with Emphasis on Surfactants; Biana Godin and Elka Touitou

Improvement of Oral Drug Absorption by Chitosan and its Derivatives; Hiraku Onishi and Yoshiharu Machida

Targeted GI Delivery; David R. Friend

Inhibition of Enzymes and Secretory Transport; Martin Werle and Andreas Bernkop-Schnürch

Enhanced Gastrointestinal Absorption of Lipophilic Drugs; Arik Dahan and Amnon Hoffman Promoted Rectal Absorption

Permeation Pathway in Rectal Absorption; Yoshiteru Watanabe

Cyclodextrins and Other Enhancers in Rectal Delivery; Hidetoshi Arima and Kaneto Uekama Enhancement of Buccal and Sublingual Absorption

Basic Biopharmaceutics of Buccal and Sublingual Absorptions; Priya Batheja, Rashmi Thakur, and Bozena Michniak

Chemical Enhancers in Buccal and Sublingual Absorptions; John D. Smart Transdermal Enhanced Delivery

The Lipid Organization in Stratum Corneum and Model Systems Based on Ceramides; Miranda W. de Jager, Maja Ponec, and Joke A. Bouwstra

Chemical Permeation Enhancement; Adrian C. Williams and Brian W. Barry

Vesicular Carriers for Enhanced Delivery through the Skin; Elka Touitou and Biana Godin

Iontophoresis in Transdermal Delivery; B. Mudry, Richard H. Guy, and M. Begoña Delgado-Charro

Electroporation as a Mode of Skin Penetration Enhancement; Michael C. Bonner and Brian W. Barry

Ultrasound in Percutaneous Absorption; Joseph Kost

Combined Chemical and Electroporation Methods of Skin Penetration Enhancement; Michael C. Bonner and Brian W. Barry

Stratum Corneum Bypassed or Removed; James C. Birchall Nasal Absorption Optimization

Physiological Factors Affecting Nasal Drug Delivery; Sian Tiong Lim, Ben Forbes, Marc B. Brown, and Gary P. Martin

Nasal Delivery of Peptide Drugs; Dennis J. Pillion, John J. Arnold, and Elias Meezan

Drug Absorption from Vagina and Uterus

Vagina and Uterus as Drug-Absorbing Organs; R. Karl Malcolm, Stephen D. McCullagh, Ryan J. Morrow, and A. David Woolfson

Strategies to Improve Systemic and Local Availability of Drugs Administered via Vaginal Route; Giuseppina Sandri, Silvia Rossi, Franca Ferrari, Maria Cristina Bonferoni, and Carla Caramella Systemic Absorption through the Ocular Route

Eye Structure and Physiological Functions; Clive G. Wilson, Ekaterina M. Semenova, Patrick M. Hughes, and Orest Olejnik

Drug Delivery Systems for Enhanced Ocular Absorption; Muhammad Abdulrazik, Francine Behar-Cohen, and Simon Benita

Ocular Penetration Enhancers; Indu Pal Kaur and Anupam Batra

Iontophoresis for Ocular Drug Delivery; Esther Eljarrat-Binstock, Joseph Frucht-Pery, and Abraham J. Domb Drug Delivery to the Central Nervous System

Structure and Function of the Blood–Brain Barrier; David J. Begley

Strategies to Overcome the Blood–Brain Barrier; Elena V. Batrakova and Alexander V. Kabanov