Trofimov / Mikhaleva / Schmidt Chemistry of Pyrroles

1. Auflage 2014
ISBN: 978-1-4822-3243-1
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 398 Seiten

Pyrrole is a heterocyclic aromatic organic compound. The book is devoted to the latest achievements of the chemistry of pyrrole, a fundamental structural unit with vitally important molecular systems (chlorophyll and hemoglobin), natural hormones, antibiotics, pigments, and pheromones. The book provides condensed, clear-cut information on novel syntheses of substituted pyrroles as key structural units of living matter (chlorophyll and hemoglobin), pharmaceuticals, and monomers for optoelectronic materials.

Autoren/Hrsg.

Trofimov, Boris A.

Mikhaleva, Al'bina I.

Schmidt, Elena Yu

Sobenina, Lyubov N.

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein

Inhaltsverzeichnis

Introduction
Synthesis of Pyrroles and N-Vinylpyrroles by the Reaction of Ketones (Ketoximes) with Acetylenes

Heterocyclization of ketoximes with acetylene
Regioselectivity of the reaction

Substituted acetylenes in reactions with ketoximes
Vinyl halogenides and dihalogenethanes as synthetic equivalents of acetylene

Intermediate stages and side reactions
d-Carbolines from 3-acylindoles and acetylene

Reaction of ketoximes with acetylene in the presence of ketones. One-pot assembly of 4-methylen-3-oxa-1-azabicyclo[3.1.0]hexanes

Transformations of aldoximes in the systems MOH/DMSO and MOH/DMSO/acetylene

Mechanism of pyrrole synthesis from ketoximes and acetylene
Novel Aspects of NH- and N-Vinylpyrroles Reactivity
Reaction with the participation of the pyrrole ring
Reactions with participation of the vinyl group
Conclusions

References
Index