Turk Immunology in Clinical Medicine

3. Auflage 2014
ISBN: 978-1-4831-8303-9
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 280 Seiten, Web PDF

Immunology in Clinical Medicine is an introduction to immunology in clinical medicine, with emphasis on immunological concepts underlying disease processes. The effect of drugs known to suppress immunological processes are considered especially in relation to whether they operate by really suppressing immunological processes or whether they have other actions. Comprised of 17 chapters, this book begins with an overview of the nature of the immune response, followed by a discussion on reactionS in the tissues mediated by humoral antibodies. The reader is then introduced to reactions in the tissues caused by the cell-mediated immune response; immunological processes in infective diseases; and the concept of autoimmunity and its relation to disease. Subsequent chapters focus on the immunology of diseases such as cancer, skin diseases, connective tissue diseases, and diseases of the intestinal tract, respiratory tract, liver, and amyloidosis. The final chapter is devoted to the role of the clinical immunologist in patient care and therapy. This monograph is intended for students and practitioners of clinical medicine.

Autoren/Hrsg.

Turk, J. L.

Inhaltsverzeichnis

1;Front Cover;1
2;Immunology in Clinical Medicine;4
3;Copyright Page;5
4;Table of
Contents;6
5;Foreword;8
6;Preface to the First Edition;10
7;Preface to the Second Edition;12
8;Chapter I.
The Nature of the bmnime Response;14
8.1;1. Introduction;14
8.2;2. The Nature of Antigens;16
8.3;3. The Nature of the Immune Response;17
8.4;4. Immunological Tolerance;27
8.5;5. Theories as to the Nature of the Immune Response;28
8.6;Bibliography;35
9;Chapter II.
Reactions in the Tissues Mediated by Humoral Antibodies;37
9.1;1. Passive Sensitization with Humoral Antibodies;37
9.2;2. Reactions Mediated by Anaphylactic Antibodies;39
9.3;3. The Arthus Reaction;43
9.4;4. Serum Sickness;47
9.5;Bibliography;55
10;Chapter III. Reactions in tiie Tissues Caused by the Cell-mediated
Immune Response;57
10.1;1. Microbial Allergies;57
10.2;2. Insect Bites;63
10.3;3. Chemical Contact Sensitiyity;64
10.4;3. Allograft (Homograft) Reaction;66
10.5;5. The Possible Role of the Cell-mediated Immune Reaction in Autoimmunity;67
10.6;6. Cellular immunity;68
10.7;Bibliography;72
11;Chapter IV.
Immunological Processes in Infective Diseases;73
11.1;Innate or Natural Immunity;74
11.2;Natural Antibodies;74
11.3;The Development of Immunity After Infection Immunity to Bacteria;76
11.4;BCG Vaccination Against Tuberculosis;77
11.5;The Immunological Spectrum in Chronic Infectious Diseases;78
11.6;Malaria and Trypanosomiasis;83
11.7;Helminthic Infections;85
11.8;Immune Mechanisms in Virus Infections;86
11.9;Bibliography;90
12;Chapter V. Immunological Deficiency Diseases: Abnormalities in Immunoglobulin Synthesis;91
12.1;A. Congenital Defects;92
12.2;B. Acquired Defects;96
12.3;Treatment of Immunological Deficiency Diseases;98
12.4;Complement Deficiency States;99
12.5;The Significance of Raised Levels of Immunoglobulins; Monoclonal Rise in Immunoglobulins;100
12.6;Polyclonal Rise in Immunoglobulins;102
12.7;Chapter VI. The Concept of Autoimmunity and its Relation to Disease;104
12.8;Bibliography;116
13;Chapter VII. Immunosuppressive Agents;117
13.1;A. The Effects of Irradiation;117
13.2;B. Immunosuppressive Drugs;120
13.3;Specific Immunological Tolerance Induced by an Immunosuppressive Agent;131
13.4;Bibliography;132
14;Chapter VIII.
Transplantatioii of Tissues and Organs;133
14.1;The Immunological Background of Allogeneic (Homologous) Graft Rejection;133
14.2;The Nature and Inheritance of the Antigens Involved in Allograft Rejection—the Possibility of Matching Donors and Recipients—HL-A Antigens;137
14.3;Bone marrow Transplantation—Graft versus Host Disease;139
14.4;Immunosuppression and Transplantation;140
14.5;The Use of "Immunological Enhancement" in avoiding Graft Rejection or "Graft versus Host'' Disease;143
14.6;Transplantation of the Liver and other Organs;144
14.7;Corneal Transplantation;145
14.8;Transplantation of Cartilage and Bone;146
14.9;Bibliography;147
15;Chapter IX.
Connective Tissue Diseases;148
15.1;Systemic Lupus Erythematosus;149
15.2;Rheumatoid Arthritis;154
15.3;Rheumatic Fever;158
15.4;Polyarteritis Nodosa;159
15.5;Diffuse Scleroderma;160
15.6;Sjögren's Disease;161
15.7;Bibliography;161
16;Chapter .. Immunological Processes in Diseases of the Kidney;162
16.1;The Experimental Production of Renal Disease;162
16.2;Nephritis in Animals Caused by Virus Infections;166
16.3;Human Renal Disease;168
16.4;The Role of Complement in Glomerulonephritis;170
16.5;The Use of Immunosuppressive Drugs in the Treatment of Chronic
Renal Disease;170
16.6;Bibliography;171
17;Chapter XI. Skin Diseases;172
17.1;Comparison of the Lesions of the Skin Produced by Immunological Means in Experimental Animals and Those Developing in Man;172
17.2;The role of the systemic absorption of bacterial antigens in the production of cutaneous conditions of "unknown aetiology";177
17.3;Chronic mucocutaneous candidiasis;178
17.4;Cutaneous lesions associated with the circulation of antigens derived from neoplastic tissues;179
17.5;Immunological reactions in the skin due to physical agents;179
17.6;Atopic eczema (atopic dermatitis);180
17.7;Discoid lupus erythematosus;181
17.8;Autoantibodies in bullous diseases of the skin and Beh.et's syndrome;182
17.9;Bibliography;184
18;Chapter XII. Related Organ-specific Immunological Diseases—Thyroid, Adrenals, Parathyroids and Stomach;186
18.1;Diseases of the Thyroid Gland;186
18.2;Adrenal glands—Addison's disease;191
18.3;Hypoparathyroidism;192
18.4;Immunological disease of the stomach—pernicious anaemia;192
18.5;Bibliography;194
19;Chapter XIII. Diseases of the Intestinal Tract, Respiratory Tract,
Liver, and Amyloidosis;195
19.1;Ulcerative Colitis and other Allergic Diseases of the Gastro-intestinal Tract;195
19.2;Diseases of the Respiratory Tract;197
19.3;The association of lung disease with rheumatoid arthritis and antinuclear factor;199
19.4;Goodpasture's syndrome;200
19.5;Sarcoidosis;200
19.6;Diseases of the Liver;203
19.7;Hepatitis-Associated Antigen;204
19.8;Amyloidosis;205
19.9;Bibliography;207
20;Chapter XIV.
Haemolytic Diseases and Thrombocytopenic Purpura;209
20.1;Rhesus Haemolytic Disease of the Newborn;209
20.2;"Autoimmune" Haemolytic Anaemias;211
20.3;Drug Induced Haemolytic Anaemia;214
20.4;Thrombocytopenic Purpura;217
20.5;The Treatment of Autoimmune Haemolytic Anaemia and Thrombocytopenic
Purpura;218
20.6;Bibliography;221
21;Chapter XV. Immunological Processes Affecting the Eye and
Nervous System;222
21.1;The Eye;222
21.2;Central Nervous System;228
21.3;Myasthenia gravis;236
21.4;Bibliography;237
22;Chapter XVI. The Immunology of Cancer;238
22.1;1. Immunological Changes in the Cancer Cells;238
22.2;2. The Immunological Reaction of the Body Against Tumours;241
22.3;3. Immunotherapy of Cancer;250
22.4;Bibliography;254
23;Chapter XVII. The Role of the Clinical Immunologist;255
23.1;The Investigation of Cell-mediated Immune Function;257
23.2;Investigation of Immunoglobulins and Humoral Antibodies;259
23.3;Detection of Autoimmune Phenomena;260
23.4;The Diagnosis of Immune-complex Diseases;261
23.5;Transplantation Immunology;261
23.6;Immunohaematology;262
23.7;The Role of the Clinical Immunologist in the Clinic and at the Bedside;262
23.8;The Training of a Clnical Immunologist;263
24;Index;266