Villa / Veiga-Crespo Antimicrobial Compounds

Current Strategies and New Alternatives
2014
ISBN: 978-3-642-40444-3
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 316 Seiten, eBook

Since penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years.This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.

Zielgruppe

Research

Autoren/Hrsg.

Veiga-Crespo, Patricia

Villa, Tomás G.

Inhaltsverzeichnis

Strategies for the design and discovery of novel antibiotics using genetic engineering and genome mining.- X-ray and Neutron Scattering Foundations for the Research in Antimicrobials.- Antibacterial, Antiviral and Antifungal Activity of Essential Oils: Mechanisms and Applications.- New antimicrobial agents of plant origin.- Advances in beta-lactam antibiotics.- The Cornerstone of Nucleic Acid-affecting Antibiotics in Bacteria.- Genetic analysis and manipulation of polyene antibiotic gene clusters as a way to produce more effective antifungal compounds.- Enzybiotics: The rush towards prevention and control of multi-resistant bacteria (MRB).- New cell wall-affecting antifungal antibiotics.- Perspectives in the research on Antimicrobial peptides.- Glycopeptides and bacterial cell walls.