Wang / Anslyn Chemosensors

Principles, Strategies, and Applications
1. Auflage 2011
ISBN: 978-1-118-01957-3
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 524 Seiten, E-Book

Reihe: Wiley series in drug discovery and development

A thorough, accessible, and general overview of chemosensors
Providing a comprehensive overview of chemosensors--organicmolecules designed to bind and sense small molecules or metalions--and their applications, Chemosensors: Principles,Strategies, and Applications is an accessible one-stop resource foranalysts, clinicians, and graduate students studying advancedchemistry and chemosensing.
Chemosensors function on a molecular level, generating a signalupon binding. The book reviews their synthesis, design, andapplications for detecting biological and organic molecules as wellas metal ions. The text highlights applications in drug discoveryand catalyses that have not been well covered elsewhere.
Covering such topics as molecular recognition, detectionmethods, design strategies, and important biological issues, thebook is broken into four sections that examine intermolecularinteractions, strategies in sensor design, detection methods, andcase studies in metal, saccharide, and amino acid sensing.
An indispensable source of information for chemical andbiomedical experts using sensors, Chemosensors includes casestudies to make the material both accessible and understandable tochemists of all backgrounds.

Autoren/Hrsg.

Wang, Binghe

Anslyn, Eric V.

Inhaltsverzeichnis

Contributors.
Preface.
SECTION 1 FORCES GOVERNING EXCHANGEABLE INTERACTIONS.
1 van der Waals Interactions and the Hydrophobic Effect(Bruce C. Gibb).
2 Ionic, Hydrogen Bond, and p -Cation Interactions(Hector Adam Velazquez and Donald Hamelberg).
3 Covalent Interactions in Chemosensor Design (Yunfeng Cheng,Xiaochuan Yang, and Binghe Wang).
4 Metal Chelation Chemistry (Dongwhan Lee).
SECTION 2 STRATEGIES TOWARD BUILDING THE DESIRED BINDINGMOIETY.
5 Scaffold Design Using Computational Chemistry (DaleDrueckhammer).
6 Combinatorial Search of Sensors (Marc Vendrell, SuihanFeng, and Young-Tae Chang).
7 Molecular Imprinting and Sensor Development (Yagang Zhangand Ken D. Shimizu).
8 Dendrimer-Based Sensors (Lin Pu).
9 Nanoparticles and Sensors (Yi-Cheun Yeh, Sarit S. Agasti,Krishnendu Saha, and Vincent M. Rotello).
10 Aptamer Selection, Phage Display, and Sensor Development(Hui Wang, Yan Chen, and Weihong Tan).
11 Sensor Development Using Existing Scaffolds (HiroyasuYamaguchi, Tomoki Ogoshi, and Akira Harada).
SECTION 3 DETECTION METHODS IN CHEMOSENSING.
12 Fluorescent Detection Principles and Strategies (RamanParkesh, Emma B. Veale, and Thorfinnur Gunnlaugsson).
13 New Fluorophore Design (Michael D. Heagy).
14 Colorimetric Sensor Design (Kevin L. Bicker, Sheryl L.Wiskur, and John J. Lavigne).
15 Electrochemical Detection (Simon R. Bayly, George Z. Chen,and Paul D. Beer).
16 Surface Plasmon Resonance and Quartz Crystal MicrobalanceMethods for Detection of Molecular Interactions (Yang Liu,Archana Jaiswal, Mark A. Poggi, and W. David Wilson).
17 Array-Based Sensors (Pavel Anzenbacher and Manuel A.Palacios).
SECTION 4 CHEMOSENSORS: CASE STUDIES.
18 Design of Cation-Selective Synthetic Fluorescent Indicators(Christoph J. Fahrni).
19 Anion Sensors (Philip A. Gale and ClaudiaCaltagirone).
20 Chemosensors: Case Studies of Indicators for OrganicMolecules (Oleksandr Rusin, Jorge O. Escobedo, and Robert M.Strongin).
21 Molecular Recognition Elements for Toxin and PathogenDetection (Daniel M. Lewallen, Duane M. Hatch, and Suri S.Iyer).
22 Chemical Sensing and Detection in Forensic Science (SimonW. Lewis).
Index.

Über Autor(innen)

BINGHE WANG, PhD, is Professor and Chair of the Departmentof Chemistry at Georgia State University as well as GeorgiaResearch Alliance Eminent Scholar in Drug Discovery. He isEditor-in-Chief of the journal Medicinal Research Reviews, serieseditor for the Wiley Series in Drug Discovery and Development, andcoeditor of Drug Delivery: Principles and Applications andCarbohydrate Recognition: Biological Problems, Methods, andApplications, both from Wiley.
ERIC V. ANSLYN, PhD, is the Norman Hackerman Professor ofChemistry at the University of Texas at Austin. His researchinterests include physical organic chemistry, molecularrecognition, sensor design, and sensor arrays.