Woo / Lai / Arcos Aliphatic and Polyhalogenated Carcinogens

Structural Bases and Biological Mechanisms
1. Auflage 2013
ISBN: 978-1-4832-1601-0
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 618 Seiten, Web PDF

Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIB: Aliphatic and Polyhalogenated Carcinogens covers environmentally and occupationally significant carcinogens of industrial origins. The book discusses the structure-activity relationships, metabolism, and environmental significance of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene pesticides, biphenyls, and related aromatics. The text also describes the structure-activity relationships, metabolism, and environmental significance of the halogenated phenoxy acids, aromatic ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and related compounds. The structure-activity relationships, metabolism, and environmental significance of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and related compounds thiocarbonyl compounds are also encompassed. The book further tackles the structure-activity relationships, metabolism, and environmental significance if fatty acids, detergents, and other surfactants with oncogenic potential. The text then looks into the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity. Chemists, geneticists, and those involved in cancer research will find the book invaluable.

Autoren/Hrsg.

Woo, Yin-Tak

Lai, David Y.

Arcos, Joseph C.

Inhaltsverzeichnis

1;Front Cover;1
2;Aliphatic and Polyhalogenated Carcinogens;4
3;Copyright Page;5
4;Table of Contents;16
5;Dedication;6
6;General Plan;8
7;Preface;12
8;Acknowledgments;14
9;Part III (Continued): STRUCTURE-ACTIVITY RELATIONSHIPS OF CHEMICAL CARCINOGENS. EFFECT OF CHEMICAL REACTIVITY, MOLECULAR GEOMETRY, AND METABOLISM ON CARCINOGENIC ACTIVITY;22
10;5. Structure-Activity Relationships;24
10.1;5.2.Nonconjugated Organic Compounds;24
11;UPDATING NOTES;436
11.1;Notes Added after Completion of Section 5.2.2.1;436
11.2;Notes Added after Completion of Section 5.2.2.2;456
11.3;Notes Added after Completion of Section 5.2.2.3;466
11.4;Notes Added after Completion of Section 5.2.2.4;472
11.5;Notes Added after Completion of Section 5.2.2.5;474
11.6;Notes Added after Completion of Section 5.2.2.7;480
11.7;Notes Added after Completion of Section 5.2.2.8;481
11.8;Notes Added after Completion of Section 5.2.2.9;482
12;APPENDIX I: Novel Types of Carcinogens;484
12.1;Carbazole;484
12.2;Anthanthrene;484
12.3;Benzene;485
12.4;Furylfuramide (Furfurylamide; AF-2);486
12.5;Niridazole;487
12.6;4-Nitropyridine N-Oxide;488
12.7;Quinoline and Its Derivatives;488
12.8;Quinoxaline 1,4-Dioxide;491
12.9;Benzoyl Chloride and Other Acylating Agents;491
12.10;Acetone Oxime (Acetoxime);492
12.11;Pronamide;493
12.12;ZAMI 1305;493
12.13;Hycanthone;494
12.14;1,3-Butadiene;497
12.15;Aniline and Azobenzene;497
12.16;4-Aminoazobenzene;498
12.17;References to Appendix I;498
13;APPENDIX II: Update to Vol. I: New Developments in Short-Term Tests for Carcinogenicity: Genetic Toxicology;502
13.1;Introduction;502
13.2;Application of Genotoxicity Data to Human Health Effects;506
13.3;Development of Genetic Toxicology Bioassays;516
13.4;Application of Short-Term Bioassays to the Assessment of Human Cancer and Mutation Risk;530
13.5;Concluding Remarks;540
13.6;References to Appendix II;540
14;APPENDIX III: Update to Vol. I: New Perspectives in Cancer Research Data Search: Modern Computer-Based Information;544
14.1;Introduction;544
14.2;Computer Databases Useful for Cancer Research;544
14.3;Automatic Selective Dissemination of Information;546
14.4;Special Cancer Databases;547
14.5;Other Databases of Interest for Cancer Research;549
14.6;Special Publications That Provide Useful Information to Cancer Researchers;551
14.7;Conclusion;552
14.8;References to Appendix III;553
15;APPENDIX IV: Update to Vol. IIA: Metabolic Activation by One-Electron and Two-Electron Oxidation in Aromatic Hydrocarbon Carcinogenesis;554
15.1;Introduction;554
15.2;Enzymology of One-Electron and Two-Electron Oxidation;558
15.3;Two-Electron Oxidation or Monooxygenation of Aromatic Hydrocarbons;559
15.4;One-Electron Oxidation of Aromatic Hydrocarbons: Radical Cations;566
15.5;Discussion;576
15.6;References to Appendix IV;583
16;Index;592