Xu / Ye / Zhao Introduction to Natural Products Chemistry

1. Auflage 2011
ISBN: 978-1-4398-6077-9
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 381 Seiten

Natural products chemistry—the chemistry of metabolite products of plants, animals and microorganisms—is involved in the investigation of biological phenomena ranging from drug mechanisms to gametophytes and receptors and drug metabolism in the human body to protein and enzyme chemistry.

Introduction to Natural Products Chemistry has collected the most important research results of natural product chemistry in China. It overviews the basic principles of isolation, structure, and characteristics of natural products and illustrates current research techniques of structure elucidation with real-life examples of wet chemistry and spectroscopic analyses (UV, IR, MS, and NMR, especially 2d-NMR, HMBC, and HMQC), bioactivity, biosynthesis, and chemical synthesis.

Specifically, this book covers:

- Extraction and isolation of natural products

- Chemistry of fungal products

- Alkaloids, sesquiterpenoids, diterpenes, and saponins

- Amino acids and peptides

- Flavonoids, anthraquinones, coumarins, and lignans

- Marine natural products

- Structural modification of active principles from traditional Chinese medicine

- Chemical synthesis of natural products

Although natural products chemistry has produced enormous results and made great contributions to human health, industry, and agriculture, only a fraction of natural resources have been rigorously studied. Chinese natural products are a gold mine for further exploration with modern technology and methods. This book represents the continuing collaboration between the fields of natural products chemistry, medicine, biology, and agriculture which will continue to discover and implement novel chemical products from natural sources.

Autoren/Hrsg.

Xu, Rensheng

Ye, Yang

Zhao, Weimin

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Chemie Analytische Chemie Umweltchemie, Lebensmittelchemie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

Introduction, Ren-Sheng Xu

Extraction and Isolation of Natural Products. Ren-Sheng Xu
Extraction of Natural Products
Separation of Natural Products
Concluding Remarks
Bibliography
References

Chemistry of Fungal Products, Zhi-Hong Xu
Introduction
Bioactive Fungal Metabolites
Mycotoxins from Fungi
Isolation and Structure Studies of Fungal Products
Perspectives
References

Alkaloids, Ren-Sheng Xu and Yang Ye
General
Characterization, Identification and Isolation
Classification
Structural Investigations of Some Alkaloids

Bibliography
References

Sesquiterpenoids, Zhong-Liang Chen
Chemical Properties, Isolation and Purification

Spectroscopic Analysis of Sesquiterpenes

Artemisinin - Chemistry, Pharmacology, and Clinical Uses

Recent Progress of Specific Sesquiterpenes

References

Diterpenes, Zhi-DaMin
Main Diterpene Skeletons

Biogenesis

Labdanes

Clerodanes

Pimaranes

Abietanes

Cassanes and Totaranes
Taxanes

Tiglianes, Ingenanes and Daphnanes
Jatrophanes and Lathyranes

Myrsinols and Euphorsctines

Ginkgolides and Pseudolaric Acid

References

Saponins, Wei-Min Zhao
Introduction
Extraction and Isolation of Saponins

Structure Determination of Saponins

Biological Activity of Saponins

Triterpenoid Saponin

Steroidal Saponins
Bibliography

References

Amino Acids and Peptides, Chang-Qi Hu and Jie-Cheng Xu
Amino Acids

Peptides

References

Flavonoids, De-Yun Kong
Overview

Extraction and Isolation of Flavonoids

Identification and Structure Study of Flavonoids

Pharmacological Study of Flavonoids

Flavonoids Assay Determination and Formulation

Conclusion

References

Anthraquinones, Yang Lu
Introduction
Physical and Chemical Properties
Extraction and Isolation

Spectral Characteristics
Examples

References

Coumarins, Ze-Nai Chen
Introduction
Structural Types

Physical and Chemical Properties
Isolation
Spectroscopic Identification

Research Example
References

Lignans, Chang-Qi Hu
Introduction
Structural Types and Characteristics of Lignans

Bioactivities of Lignans

References

Other Natural Bioactive Compounds, Ren-Seng Xu
Sulfur Compounds
Cyanide Compounds

Coixenolide

Resveratrol

Muscone

Cardiac Glycosides
Bibliography

References

Marine Natural Products, Yue-Wei Guo and Wen Zhang
Introduction
Marine Plants
Marine Invertebrates

Marine Microorganisms and Phytoplankton

Miscellaneous
Examples

Epilogue (Outlook)

References

Structural Modification of Active Principles from TCM, Da-Yuan Zhu
Introduction
Anti-malaria Drug Arthemether

Anti-hepatitis Drug Bifendate

Anti-AD Drug Huperzine A

Antiarrhythmia Drug Changrolin

Antineoplastic Drugs

Computer-Aided Drug Design

References

Chemical Synthesis of Natural Products, Wen-Hu Duan
Alkaloids
Terpene

Flavonoids

Synthesis of Anthraquinones

Lignans

Synthesis of Macrolide Antibiotics
Bibliography

References