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E-Book

E-Book, Englisch, 324 Seiten

Reihe: Woodhead Publishing Series in Biomaterials

Zhang Switchable and Responsive Surfaces and Materials for Biomedical Applications


1. Auflage 2014
ISBN: 978-0-85709-717-0
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 324 Seiten

Reihe: Woodhead Publishing Series in Biomaterials

ISBN: 978-0-85709-717-0
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark



Surface modification of biomaterials can ultimately determine whether a material is accepted or rejected from the human body, and a responsive surface can further make the material 'smart' and 'intelligent'. Switchable and Responsive Surfaces and Materials for Biomedical Applications outlines synthetic and biological materials that are responsive under different stimuli, their surface design and modification techniques, and applicability in regenerative medicine/tissue engineering, drug delivery, medical devices, and biomedical diagnostics. Part one provides a detailed overview of switchable and responsive materials and surfaces, exploring thermo-responsive polymers, environmentally responsive polyelectrolytes and zwitterionic polymers, as well as peptide-based and photonic sensitive switchable materials. Further chapters include a detailed overview of the preparation and analysis of switchable polymer brushes and copolymers for biomedical application. Part two explores the biological interactions and biomedical applications of switchable surfaces, where expert analysis is provided on the interaction of switchable surfaces with proteins and cells. The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into the application of responsive polymers in implantable medical devices and biosensors. - A comprehensive overview of switchable and responsive materials and surfaces - Includes in depth analysis of thermo-responsive polymers, photonic sensitive materials and peptide-based surfaces - Detailed exploration of biological interactions of responsive and switchable surfaces, covering stimuli-sensitive polymers for drug delivery, surfaces with proteins/cells and application of polymers in medical devices

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1;Front
Cover;1
2;Related titles;3
3;Switchable and Responsive Surfaces and Materials for Biomedical Applications;4
4;Copyright;5
5;Contents;6
6;List of contributors;10
7;Woodhead Publishing Series in Biomaterials;12
8;Introduction;16
8.1;Responsive materials;17
8.2;Responsive surface modification;17
8.3;Responsive surface-biological system interactions;17
8.4;Multidisplinary research toward different biomedical applications;17
8.5;References;18
9;Part One -
Switchable and responsive materials and surfaces;20
9.1;1 - Thermo-responsive polymers: structure and design of smart materials;22
9.1.1;1.1 Introduction;22
9.1.2;1.2 Thermo-responsive polymers and their characteristics;23
9.1.3;1.3 Types of thermo-responsive polymers;25
9.1.4;1.4 Physical forms of switchable materials and their applications;39
9.1.5;1.5 Summary;49
9.1.6;References;50
9.2;2 - Environmentally responsive polyelectrolytes and zwitterionic polymers;64
9.2.1;2.1 Introduction;64
9.2.2;2.2 Monomer subunits and polymerization approaches;65
9.2.3;2.3 General solution properties;68
9.2.4;2.4 Stimuli-induced changes and their applications;71
9.2.5;2.5 Future trends;77
9.2.6;2.6 Sources of further information;77
9.2.7;References;78
9.3;3 - Peptide-based switchable and responsive surfaces;84
9.3.1;3.1 Introduction;84
9.3.2;3.2 Preparation of peptide surfaces;87
9.3.3;3.3 Responsive peptide surfaces;91
9.3.4;3.4 Peptides attached to responsive surfaces;96
9.3.5;3.5 Protein surfaces;100
9.3.6;3.6 Physical properties and characterisation;102
9.3.7;3.7 Emerging applications;107
9.3.8;3.8 Future trends;108
9.3.9;References;109
9.4;4 - Photonic sensitive switchable materials;112
9.4.1;4.1 Introduction;112
9.4.2;4.2 Photonic sensitive switchable materials;113
9.4.3;4.3 Potential applications;118
9.4.4;4.4 Conclusions and future trends;130
9.4.5;References;131
9.5;5 - Responsive polymer brushes for biomedical applications;138
9.5.1;5.1 Introduction;138
9.5.2;5.2 Brush architecture;142
9.5.3;5.3 Types of responsive polymer brushes;143
9.5.4;5.4 Biomedical applications;150
9.5.5;5.5 Summary and future trends;157
9.5.6;References;160
9.6;6 - Preparation and analysis of switchable copolymers for biomedical application;166
9.6.1;6.1 Introduction;166
9.6.2;6.2 Switchable copolymer coatings;166
9.6.3;6.3 Advanced analytical techniques;172
9.6.4;6.4 Future trends;180
9.6.5;6.5 Sources of further information;180
9.6.6;References;180
10;Part Two -
Biological interactions and biomedical applications of switchable surfaces;184
10.1;7 - Interaction of switchable biomaterials surfaces with proteins;186
10.1.1;7.1 Introduction;186
10.1.2;7.2 Protein adsorption on surfaces;187
10.1.3;7.3 Protein adsorption on thermo-responsive surfaces;188
10.1.4;7.4 Protein adsorption on pH and/or ionic strength-responsive surfaces;193
10.1.5;7.5 Protein adsorption on other responsive surfaces;197
10.1.6;7.6 Synergistic effect of surface chemistry and nanostructures on protein adsorption;199
10.1.7;7.7 Aspects for future research;200
10.1.8;Acknowledgments;201
10.1.9;References;202
10.2;8 - Interaction of responsive/switchable surfaces with cells;208
10.2.1;8.1 Introduction;208
10.2.2;8.2 Controlling stem cell behavior;209
10.2.3;8.3 Interfacial properties;210
10.2.4;8.4 Physical behavior;213
10.2.5;8.5 Future trends;217
10.2.6;References;218
10.2.7;Further reading;220
10.3;9 - Temperature-responsive polymers for cell culture and tissue engineering applications;222
10.3.1;9.1 Introduction;222
10.3.2;9.2 Methods for preparing temperature-responsive cell culture surfaces (TRCSs) and their characteristics;223
10.3.3;9.3 Cell sheet-based regenerative medicine;239
10.3.4;9.4 Future application of temperature-responsive cell culture surface to support and promote regenerative medicine field;242
10.3.5;References;244
10.4;10 - Stimuli-sensitive polymers for drug delivery and diagnostic systems interacting with biosurfaces;254
10.4.1;10.1 Introduction;254
10.4.2;10.2 Polymers sensitive to body’s internal stimuli;255
10.4.3;10.3 Polymers sensitive to the body’s external stimuli;264
10.4.4;10.4 Future trends;270
10.4.5;References;271
10.5;11 - Application of responsive polymers in implantable medical devices and biosensors;278
10.5.1;11.1 Introduction;278
10.5.2;11.2 Biocompatibility of medical devices and responsive polymers;279
10.5.3;11.3 Cardiovascular devices;281
10.5.4;11.4 Drug delivery/infection control coatings and devices;288
10.5.5;11.5 Surgical devices;290
10.5.6;11.6 Dental and orthopedic devices;293
10.5.7;11.7 Ophthalmic devices;295
10.5.8;11.8 Respiratory devices;297
10.5.9;11.9 Gastrointestinal devices;298
10.5.10;11.10 Urogenital devices/urinary devices;298
10.5.11;11.11 Insulin delivery devices for diabetes management;299
10.5.12;11.12 Biosensors;300
10.5.13;11.13 Summary;306
10.5.14;References;307
11;Index;318


Woodhead Publishing Series in Biomaterials


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2 Surfaces and interfaces for biomaterials
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43 MEMS for biomedical applications
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