Zhou / Chen Multimodality Imaging

For Intravascular Application
1. Auflage 2019
ISBN: 978-981-10-6307-7
Verlag: Springer Nature Singapore
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 277 Seiten

This book provides a state-of-the-art overview of the combined use of imaging modalities to obtain important functional and morphological information on intravascular disease and enhance disease detection. It discusses the integration of intravascular ultrasound (IVUS, intravascular optical coherence tomography (OCT), intravascular photoacoustic imaging (IVPA) and acoustic radiation force optical coherence elastography (ARF-OCE), and introduces the integration of multimodality imaging systems, such as IR and florescence. It includes the latest research advances and numerous imaging photos to offer readers insights into current intravascular applications. It is a valuable resource for students, scientists and physicians wanting to gain a deeper understanding of multimodality imaging tools.

Prof. Qifa Zhou is currently a Professor at Department of Biomedical Engineering and Ophthalmology at University of Southern California, Los Angeles, CA. Prof. Zhou is a Fellow in SPIE, AIBME and IEEE. He is a member of the ferroelectric Committee, UFFC Society in IEEE. He is also a member of the technical program Committee of Internal Ultrasound Symposium (IUS) in IEEE and photoacoustics plus ultrasound in SPIE Photonics West.  He is an Associate Editor and Chapter Chair of IEEE UFFC. His current research interests include the MEMS technology, nano-medicine, fabrication of high frequency ultrasound transducers/arrays for intravascular imaging applications as well as photoacoustic imaging technology. He has published more than 230 technique papers.  Prof. Zhongping Chen is currently a Professor in the Department of Biomedical Engineering at University of California, Irvine, CA. He is also a co-founder and Board Chairman of OCT Medical Imaigng Inc.. Prof. Chen is a Fellow of AIMBE, SPIE and OSA. He is an international expert on the OCT imaging and pioneered the development of Doppler OCT and OCT angiography.  His current research include the development of optical coherence elastography and multimodality intravascular imaging technology. He has published more than 280 technique papers.

Autoren/Hrsg.

Zhou, Qifa

Chen, Zhongping

Inhaltsverzeichnis

1;Preface;5
2;Contents;7
3;Contributors;9
4;1 Introduction to Multimodality Intravascular Imaging;11
4.1;References;14
5;2 Advances in Multi-frequency Intravascular Ultrasound (IVUS);20
5.1;Background;20
5.2;Ultrahigh-Frequency IVUS Imaging at 80-MHz;23
5.2.1;Introduction;23
5.2.2;Design and Fabrication of 80-MHz IVUS Probe;24
5.2.3;Ex Vivo 80-MHz IVUS Imaging;26
5.2.4;80-MHz Intravascular Photoacoustic Imaging (IVPA);27
5.2.5;Summary;29
5.3;Multi-frequency IVUS Imaging;31
5.3.1;Introduction;31
5.3.2;Design and Fabrication of Multi-frequency Catheter;33
5.3.3;Characterization of Multi-frequency IVUS Imaging System;36
5.3.4;Phantom Imaging and Ex Vivo Human Coronary Artery Imaging;39
5.3.5;Summary;42
5.4;Some Advances in High-Frequency IUVS;44
5.4.1;Introduction;44
5.4.2;Development of PIN-PMN-PT 1-3 Composite IVUS Transducer;46
5.4.3;IVUS with Virtual Source Synthetic Aperture Focusing and Coherence Factor Weighting;50
5.4.4;IVUS Imaging with a Modulated Excitation;55
5.5;References;57
6;3 The Integration of IVUS and OCT;65
6.1;Introduction;65
6.2;IVUS-OCT Fundamentals;66
6.2.1;Ultrasound Sub-system;66
6.2.2;OCT Sub-system;67
6.2.3;Motion Control Unit;68
6.2.4;DAQ and Signal Processing;69
6.2.5;IVUS-OCT Imaging Catheter Design;69
6.2.6;Key Measures;71
6.3;Case Study: IVUS-OCT to Detect Vulnerable Plaques;73
6.3.1;Background;73
6.3.2;Technical Advances;74
6.3.3;In Vivo and Ex Vivo Validations;78
6.4;Other Studies Related to IVUS-OCT;79
6.4.1;IVUS-OCT for Angioplasty Planning and Follow-Up;79
6.4.2;Tri-modality Imaging System;81
6.5;References;82
7;4 Intravascular Photoacoustic Imaging of Lipid-Laden Plaques: From Fundamental Concept Toward Clinical Translation;88
7.1;Introduction;88
7.2;Principles of Photoacoustic Imaging;90
7.2.1;Light-to-Sound Conversion;90
7.2.2;Contrast Mechanism and Optical Windows for Lipid Imaging;93
7.3;Catheter-Based IVPA/US Imaging System;95
7.3.1;Excitation Laser Source;96
7.3.2;Hybrid Fiber-Optic Rotary Joint;97
7.3.3;IVPA/US Catheter;98
7.3.4;Image Reconstruction;101
7.4;Preclinical Validation;101
7.4.1;Human Coronary Atherosclerosis;102
7.4.2;Animal Models;102
7.5;Exogenous Contrast Agents;104
7.6;Future Development and Potential Clinical Applications;106
7.7;References;107
8;5 Contrast-Enhanced Dual-Frequency Super-Harmonic Intravascular Ultrasound (IVUS) Imaging;112
8.1;Background;112
8.2;Dual-Frequency IVUS Transducer;115
8.2.1;Dual-Frequency Transducer Structure Design;115
8.2.2;Acoustic Filter for Stack Layer Transducers;117
8.2.3;Microwave Analysis of Piezoelectric Transducers;119
8.2.4;Anti-matching Layer for High-Frequency Receiving Wave;123
8.2.5;Passive Amplifier for the Low-Frequency Transmitting Wave;128
8.2.6;Overall Performance of the Acoustic Filter;131
8.2.7;Materials Selection;133
8.2.8;Fabrication;134
8.2.9;Acoustic Characterization;135
8.3;Imaging Process;136
8.3.1;Microbubble Response Test;136
8.3.2;Fundamental Frequency Imaging;137
8.3.3;Super-Harmonic Imaging;138
8.3.4;Chorioallantoic Membrane Imaging In Vivo;139
8.4;Preliminary Results;140
8.4.1;Prototype and Housing;140
8.4.2;Electrical Characterization;141
8.4.3;Acoustic Characterization;142
8.4.4;Microbubble Response;144
8.4.5;Fundamental Imaging;146
8.4.6;Super-Harmonic Imaging;146
8.4.7;In Vivo Contrast Detection of Microvascular Flow;147
8.5;Performance Optimization;149
8.5.1;Optimization Approaches;149
8.5.2;Transmission Output;150
8.5.3;Imaging Results;152
8.6;Summary;154
8.7;References;155
9;6 Dual-Modality Fluorescence Lifetime and Intravascular Ultrasound for Label-Free Intravascular Coronary Imaging;159
9.1;Introduction;159
9.2;Autofluorescence of Atherosclerotic Arteries;160
9.2.1;Origin of Autofluorescence;160
9.2.2;History of Fluorescence Spectroscopy Studies of Atherosclerosis;160
9.2.3;Time-Resolved Fluorescence Spectroscopy and Imaging Studies of Atherosclerotic Lesions;161
9.2.4;Challenges for Implementing FLIm in an Intravascular Catheter;164
9.3;FLIm-IVUS Catheter System Instrumentation;165
9.3.1;Principle of the High-Speed Fluorescence Lifetime Imaging Instrumentation;165
9.3.2;FLIm-IVUS Intravascular Catheter System;166
9.4;Methods for Data Processing;168
9.5;FLIm-IVUS Imaging of In Vivo Swine Coronary Arteries;169
9.6;FLIm-IVUS Imaging of Ex Vivo Human Coronary Arteries;170
9.7;Discussion;174
9.8;References;174
10;7 Intravascular Dual-Modality Imaging (NIRF/IVUS, NIRS/IVUS, IVOCT/NIRF, and IVOCT/NIRS);178
10.1;Introduction;178
10.2;Principle;179
10.3;Methods and Results;181
10.3.1;Integrated IVOCT/NIRS and IVOCT/NIRF Imaging Systems;181
10.4;Integrated IVUS/NIRS and IVUS/NIRF Imaging Systems;187
10.4.1;Integrated IVUS and NIRF System;187
10.4.2;In Vivo Animal Study;188
10.4.3;Integrated IVUS and NIRS System;189
10.4.4;Clinical Validation Studies;189
10.5;Summary;190
10.6;References;191
11;8 Tri-Modality Intravascular Imaging System;195
11.1;Introduction;195
11.2;Method;197
11.2.1;Tri-Modality Imaging System Design;197
11.2.2;Tri-Modality Imaging Probe;200
11.2.3;Data Acquisition and Process;202
11.3;Experiments;202
11.3.1;Ex Vivo Experiment of the Tri-Modality Imaging System with Cy 5.5;202
11.3.2;Ex Vivo Experiment of the Tri-Modality Imaging System with ICG;204
11.4;Summary;207
11.5;References;207
12;9 Acoustic Radiation Force Optical Coherence Elastography;211
12.1;Introduction;211
12.2;Compressional and Shear Wave Methods Using OCE;214
12.2.1;Doppler OCE;215
12.2.2;Shear Velocity Estimation;216
12.3;Quantitative ARF-OCE Using Compressional Wave;219
12.4;ARF-OCE for Intravascular Imaging;224
12.5;Summary;226
12.6;References;227
13;10 Therapeutic IVUS and Contrast Imaging;231
13.1;Scope;231
13.2;Introduction and Evolution of IVUS Technology;231
13.3;IVUS Transducer Technology Evolution in the Context of Therapeutic and Microbubble Applications;234
13.3.1;Single Element IVUS;234
13.3.2;Phased Array IVUS;236
13.3.3;Capacitive Micromachined Transducers (cMUT);236
13.4;Therapeutic Applications of IVUS;237
13.4.1;Therapeutic Applications of IVUS: Microbubble-Enhanced Drug and Gene Delivery;239
13.5;Microbubbles in IVUS Imaging;241
13.5.1;IVUS Specific Applications of Microbubbles for Imaging;244
13.5.2;Molecular Imaging in the IVUS Field;249
13.6;Integrated IVUS and Microbubble Generation Devices;250
13.7;Integrated Ultrasound and Optical Imaging Devices;252
13.8;Conclusions;252
13.9;References;253
14;11 High-Resolution Ultrasound Imaging System;261
14.1;Introduction;261
14.2;Pulse Generation;263
14.3;Receiver Circuitry;265
14.3.1;Termination and Protection;267
14.3.2;Low Noise Amplifier and TGC;267
14.3.3;Analog to Digital Converter;269
14.3.4;Data Process Unit;269
14.3.5;Computer Connection;270
14.4;Data Process;271
14.4.1;Digital Filter;271
14.4.2;Envelope Detection;272
14.4.3;Digital Scan Convertor;273
14.4.4;Imaging Evaluation;274
14.5;Summary;275
14.6;References;276