Ariëns Drug Design

Medicinal Chemistry: A Series of Monographs, Vol. 5
1. Auflage 2013
ISBN: 978-1-4832-1607-2
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 374 Seiten, Web PDF

Drug Design, Volume V covers the fundamental approaches to the development of bioactive compounds. The book discusses the utilization of operational schemes for analog synthesis in drug design; the design of enzyme inhibitors (transition state analogs); and the significance of structure-absorption-distribution relationships for drug design. The text describes the role of charge-transfer processes in the action of bioactive materials, as well as the approaches to the rational combination of antimetabolites for cancer chemotherapy. The physicochemical, quantum chemical, and other theoretical techniques for the understanding of the mechanism of action of central nervous system (CNS) agents, such as psychoactive drugs, narcotics, and narcotic antagonists and anesthetics, are also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design will find the book invaluable.

Autoren/Hrsg.

Ariëns, E. J.

Inhaltsverzeichnis

1;Front Cover;1
2;Drug Design;4
3;Copyright Page;5
4;Table of Contents;6
5;List of Contributors;10
6;Preface;12
7;Contents of Other Volumes;14
8;Chapter 1. Utilization of Operational Schemes for Analog Synthesis in Drug Design;20
8.1;I. Introduction;20
8.2;II. Operational Scheme for Aromatic Substitution;21
8.3;III. Operational Scheme for Side Chains;27
8.4;IV. Examples;30
8.5;V. Rational Follow-up to the Schemes;38
8.6;VI. Conclusion;39
8.7;References;40
9;Chapter 2. The Design of Enzyme Inhibitors: Transition State Analogs;42
9.1;I. Introduction;43
9.2;II. Theory of the Transition State Analog Approach;44
9.3;III. Transition State Analogs;51
9.4;IV. Natural Transition State Analog Inhibitors;87
9.5;V. Synthetic Enzymes;93
9.6;References;95
10;Chapter 3. Structure-Absorption-Distribution Relationships: Significance for Drug Design;100
10.1;I. Introduction;100
10.2;II. The Earlier Hypotheses Relating to the Membrane Permeability or Pharmacological Activity with Partition Coefficients;101
10.3;III. Quantitative Correlations Using Multiple Regression Analysis and Substituent Constants;103
10.4;IV. Summary;146
10.5;References;147
11;Chapter 4. The Role of Charge-Transfer Processes in the Action of Bioactive Materials;152
11.1;I. Introduction;152
11.2;II. Fundamentals of the Charge-Transfer Process;154
11.3;III. Charge Transfer in Biological Systems;159
11.4;IV. Summary;181
11.5;References;183
12;Chapter 5. Approaches to the Rational Combination of Antimetabolites for Cancer Chemotherapy;188
12.1;I. General Introduction;189
12.2;II. Intracellular Metabolic Interactions;191
12.3;III. Alterations in Intracellular Metabolism;237
12.4;IV. Transport or Uptake Interactions;245
12.5;V. Scheduling;250
12.6;VI. Remote Systemic Biotransformation;251
12.7;VII. Modification of Host Nutrients and Toxicity;255
12.8;VIII. Non metabolic Combinations;261
12.9;IX. Concluding Remarks;263
12.10;References;264
13;Chapter 6. Physicochemical, Quantum Chemical, and Other Theoretical Techniques for the Understanding of the Mechanism of Action of CNS Agents: Psychoactive Drugs,Narcotics, and Narcotic Antagonists and Anesthetics;270
13.1;I. Introduction;271
13.2;II. Evaluation of Quantum Chemical Computational Methods;275
13.3;III. Psychoactive Drugs;295
13.4;IV. Narcotics and Narcotic Antagonists;320
13.5;V. Anesthetics;343
13.6;VI. Recent Developments in Sensitive Methods of Analyses for Normal Neurotransmitters and Their Metobolites;348
13.7;VII. Overall Perspective;350
13.8;References;352
14;Index;360