Chadwick / Goode Mitochondrial Biology

New Perspectives
1. Auflage 2007
ISBN: 978-0-470-72519-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 254 Seiten, E-Book

Reihe: Novartis Foundation Symposia

With the recent renaissance in mitochondrial biology and increasingrecognition of their role in many diseases, this book provides atimely summary of the current state-of-the-art in mitochondrialresearch. The book opens with the regulation of mitochondrialreplication and biogenesis and reviews the mechanisms andfunctional consequences of mitochondrial fission and fusion.Further chapters address mitochondria and oxidative stress andtheir roles in cell signalling and cell death. The book includesextensive, fascinating discussion of the biochemistry ofmitochondrial cell signalling (especially involving calcium) and ofoxidative stress. The nature of the proteins engaged in theseprocesses, many only recently discovered, is covered in detail.
Mitochondria have been strongly implicated in neurodegenerativediseases such as Parkinson's, Huntington's andamyotrophic lateral sclerosis. They are also affected in cancer,ageing and cardiovascular disease. The final section of the bookreviews mitochondrial mutations and their consequences in ageingand other phenotypic manifestations. The authors discuss howmitochondrial proteins might constitute important therapeutictargets and describe initial attempts to develop compounds that canregulate their function.

Autoren/Hrsg.

Chadwick, Derek J.

Goode, Jamie A.

Inhaltsverzeichnis

Symposium on New perspectives on mitochondrial biolog y, held atthe Novartis Foundation, London, 28-30 November 2006.
Editors: Derek J. Chadwick (Organizer) and Jamie Goode.
This symposium is based on a proposal by Michael Duchen.
David G. Nicholls Chair's introduction.
Albert Neutzner, Richard J. Youle and MariuszKarbowski, Outer mitochondrial membrane protein degradation bythe proteasome.
Discussion.
Sarah E. Haigh, Gilad Twig, Anthony A. J. Molina, Jakob D.Wikstrom, Motti Deutsch and Orian S. ShirihaiPA-GFP: a window into the subcellular adventures of the individualmitochondrion.
Discussion.
Luca Scorrano, Multiple functions of mitochondria-shapingproteins. Discussion.
Bruce M. Spiegelman, Transcriptional control ofmitochondrial energy metabolism through the PGC1coactivators.
Discussion.
Charles Affourtit, Paul G. Crichton, Nadeene Parker andMartin D. Brand, Novel uncoupling proteins.
Discussion.
Cecilia Giulivi, Mitochondria as generators and targetsof nitric oxide. Discussion.
György Hajnóczky, Masao Saotome, GyörgyCsordás, David Weaver and Muqing Yi, Calciumsignalling and mitochondrial motility.
Discussion.
Anna Romagnoli, Paola Aguiari, Diego De Stefani, SaraLeo, Saverio Marchi, Alessandro Rimessi, Erika Zecchini,Paolo Pinton and Rosario Rizzuto, Endoplasmicreticulum/mitochondria calcium cross-talk.
Discussion.
Brian O'Rourke, Sonia Cortassa, Fadi Akar andMiguel Aon, Mitochondrial ion channels in cardiac functionand dysfunction.
Discussion.
Paolo Bernardi and Michael Forte, Themitochondrial permeability transition pore.
Discussion.
Dominic James, Philippe A. Parone, Olivier Terradillos,Safa Lucken-Ardjomande, Sylvie Montessuit and Jean-ClaudeMartinou, Mechanisms of mitochondrial outer membranepermeabilization.
Discussion.
M. Flint Beal, Mitochondria and neurodegeneration.
Discussion.
Mügen Terzioglu and Nils-Göran Larsson,Mitochondrial dysfunction in mammalian ageing.
Discussion.
Eric A. Schon and Salvatore DiMauro. Mitochondrialmutations: genotype to phenotype.
Discussion.
Contributor Index.
Subject index.

Über Autor(innen)

The Novartis Foundation is an international scientific andeducational charity which promotes the study and general knowledgeof science and in particular encourages international co-operationin scientific research.
Chairman: David G Nicholls, Buck Institute for Age Research,Novato, USA.