Muscle 2-Volume Set

Fundamental Biology and Mechanisms of Disease
Erscheinungsjahr 2012
ISBN: 978-0-12-381510-1
Verlag: Elsevier Science

Buch, Englisch, 1398 Seiten, Format (B × H): 243 mm x 303 mm, Gewicht: 4912 g

A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte. Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit.

- The only resource to focus on science before the clinical work and therapeutics
- Tiered approach to subject: discussion first of normal muscle function through pathological/disease state changes, and ending each section with therapeutic interventions
- Coverage of topics ranging from basic physiology to newly discovered molecular mechanisms of muscle diseases for all three muscle types: cardiac, skeletal, and smooth

Zielgruppe

The primary audience for this work is entry level and experienced researchers, practicing clinicians, postdocs, graduate students, and medical students across molecular and muscle medicine, developmental biology, molecular biology, cell biology, physiology, pathology, pharmacology, cardiology, translational medicine and biomedicine.

Autoren/Hrsg.

Hill, Joseph

Olson, Eric

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie

Inhaltsverzeichnis

Part 1: Introduction 1. An Introduction to Muscle 2. A History of Muscle Part II: Cardiac Muscle Section A: Basic Physiology 3. Cardiac Myocyte Specification and Differentiation 4. Transcriptional Control of Cardiogenesis 5. Cardiomyocyte Ultrastructure 6. Overview of CArdiac Muscle Physiology 7. Ionic Fluxes and Genesis of the Cardiac Action Potential 8. G-Protein-Coupled Receptors in the Heart 9. Receptor Tyrosine Kinases in Cardiac Muscle 10. Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network 11. Calcium Fluxes and Homeostasis 12. Excitation-Contraction Coupling in the Heart 13. Role of Sarcomeres in Cellular Tension, Shortening, and Signaling in Cardiac Muscle 14. Cardiovascular Mechanotransduction 15. Cardiomyocyte Metabolism: All Is in Flux 16. Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function 17. Mitochondrial Morphology and Function 18. Genetics and Genomics in Cardiovascular Gene Discovery 19. Cardiovascular Proteomics: Assessment of Protein Post-Translational Modifications Section B: Adaptations and Response 20. Adaption and Responses: Myocardial Innervations adn Neural Control 21. Regulation of Cardiac Systolic Function and Contractility 22. Intracellular Signaling Pathways in Cardiac Remodeling 23. Oxidative Stress and Cardiac Muscle 24. Physiologic and Molecular Responses of the Heart to Chronic Exercise 25. Epigenetics in Cardiovascular Biology 26. Cardiac MicroRNAs 27. Protein Quality Control in Cardiomyocytes 28. Cardioprotection 29. Cardiac Fibrosis: Cellular and Molecular Determinants 30. Autophagy in Cardiac Physiology and Disease 31. Programmed Cardiomyocyte Death in Heart Disease 32. Wnt and Notch: Potent Regulators of Cardiomyocyte Specification, Proliferation, and Differentiation Section C: Myocardial Disease 33. Congenital Cardiomyopathies 34. Genetics of Congenital Heart Disease 35. Mechanisms of Stress-Induced Cardiac Hypertrophy 36. Ischemic Heart Disease 37. The Pathophysiology of Heart Failure 38. The Right Ventricle: Reemergence of the Forgotten Ventricle 39. Mammalian Myocardial Regeneration 40. The Structural Basis of Arrhythmia 41. Molecular and Cellular Mechanisms of Cardiac Arrhythmias 42. Genetic Mechanisms of Arrhythmia 43. Infiltrative adn Protein Misfolding Myocardial Diseases 44. Cardiac Aging: From Humans to Molecules 45. Adrenergic Receptor Polymorphisms in Heart Failure 46. Cardiac Gene Therapy 47. Protein Kinases in the Heart: Lessons Learned from Targeted Cancer Therapeutics 48. Cell Therapy for Cardiac Disease 49. Chemical Genetics of Cardiac Regeneration 50. Device Therapy for Systolic Ventricular Failure 51. Novel Therapeutic Targets and Strategies against Myocardial Diseases Part III: Skeletal Muscle Section A: Basic Physiology 52. Skeletal Muscle Development 53. Skeletal Muscle: Architecture of Membrane Systems 54. The Vertebrate Neuromuscular Junction 55. Neuromuscular Interactions that Control Muscle Function and Adaptation 56. Control of Resting CA2+ Concentration in Skeletal Muscle 57. Skeletal Muscle Excitation-Contraction Coupling 58. The Contractile Machinery of Skeletal Muscle 59. Skeletal Muscle Metabolism 60. Skeletal Muscle Fiber Types Section B: Adaptations and Response 61. Regulation of Skeletal Muscle Development and Function by microRNAs 62. Musculoskeletal Tissue Injury and Repair: Role of Stem Cells, Their Differentiation, and Paracrine Effects 63. Immunological Responses to Mu

Über Autor(innen)

Hill, Joseph
Dr. Hill is a cardiologist-scientist whose research strives to decipher mechanisms of structural, functional, and electrical remodeling of the heart. He earned M.D. and Ph.D. degrees from Duke University, conducted postdoctoral scientific training with Jean-Pierre Changeux at the Institut Pasteur in Paris, and pursued clinical training in Internal Medicine and Cardiology at Brigham and Women's Hospital, Harvard Medical School. Dr. Hill served on faculty at the University of Iowa for 5 years before moving in 2002 to UT Southwestern as Chief of Cardiology and Director of the Harry S. Moss Heart Center. Dr. Hill's honors include election to the Association of University Cardiologists and the Association of American Physicians. Dr. Hill maintains an active clinical practice focusing on general cardiology, hypertension, and heart failure.

Olson, Eric
Dr. Olson has dedicated his career to deciphering mechanisms that control muscle gene regulation and development. He received B.A. and Ph.D. degrees from Wake Forest University. After postdoctoral training with Luis Glaser at Washington University School of Medicine, he joined the Department of Biochemistry and Molecular Biology at the M. D. Anderson Cancer Center in 1984 and became Professor and Chairman in 1991. In 1995, he founded the Department of Molecular Biology at UT Southwestern. Dr. Olson has received numerous prestigious awards and honors. He is a member of the American Academy of Arts and Sciences, and its Institute of Medicine.