Ishaaya / Nauen / Horowitz Insecticides Design Using Advanced Technologies

1. Auflage 2007
ISBN: 978-3-540-46907-0
Verlag: Springer Berlin Heidelberg
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 314 Seiten

Among the highlights of this book are the use of nanotechnology to increase potency of available insecticides, the use of genetic engineering techniques for controlling insect pests, the development of novel insecticides that bind to unique biochemical receptors, the exploration of natural products as a source for environmentally acceptable insecticides, and the use of insect genomics and cell lines for determining biological and biochemical modes of action of new insecticides.

Autoren/Hrsg.

Ishaaya, Isaac

Nauen, Ralf

Horowitz, A. Rami

Inhaltsverzeichnis

1;Preface;5
2;Contents;6
3;Contributors;12
4;1 Nanosuspensions: Emerging Novel Agrochemical Formulations;14
4.1;1 Introduction;14
4.2;2 Solubility Enhancement Through Nanoization;16
4.3;3 Stabilization of Nanosuspensions;20
4.4;4 Preparation of Nanosuspensions;27
4.5;5 Characterization of Nanoparticulate Systems;37
4.6;6 Nanoformulations of Crop-Protection Chemicals;39
4.7;7 Nanoparticulate Formulation of Novaluron;41
4.8;8 Conclusions;45
4.9;References;45
5;2 Pharmacokinetics: Computational Versus Experimental Approaches to Optimize Insecticidal Chemistry;54
5.1;1 Introduction;54
5.2;2 Pharmacokinetic Modeling;56
5.3;3 Compartmental Modeling;65
5.4;4 Simple Models;66
5.5;5 Complex Models;67
5.6;6 Conclusions;77
5.7;References;77
6;3 High-Throughput Screening and Insect Genomics for New Insecticide Leads;80
6.1;1 Introduction;80
6.2;2 Approaches for Insecticide Lead Identification;81
6.3;3 Conclusion;96
6.4;References;96
7;4 Transgenic and Paratransgenic Insects in Crop Protection;100
7.1;1 Introduction;100
7.2;2 The Sterile Insect Technique;100
7.3;3 Conditional Lethal Genes;101
7.4;4 Regulatory Aspects;102
7.5;5 Symbiosis and Microbiology;103
7.6;6 Conclusions;112
7.7;References;113
8;5 Future Insecticides Targeting Genes Involved in the Regulation of Molting and Metamorphosis;118
8.1;1 Introduction;118
8.2;2 Hormonal Regulation of Molting and Metamorphosis;119
8.3;3 Genes Involved in Molting and Metamorphosis as Target Sites for the Design of Biorational Insecticides;128
8.4;4 Utilization of Genes Involved in Molting and Metamorphosis for Development of Pest Management Tools;137
8.5;References;139
9;6 Trypsin Modulating Oostatic Factor for Developing Resistant Crops;148
9.1;1 Introduction;148
9.2;2 Biochemical and Physiological Studies;149
9.3;3 Molecular Biology Studies;155
9.4;4 Insect Resistance and Safety Issues;157
9.5;References;160
10;7 Nicotinic Acetylcholine Receptors as a Continuous Source for Rational Insecticides;164
10.1;1 Introduction;164
10.2;2 Structure of the Nicotinic Acetylcholine Receptors (nAChRs);166
10.3;3 Agonists vs. Antagonists;168
10.4;4 Ligand Binding;176
10.5;5 nAChR-Based Screening Assays;194
10.6;6 Resistance;194
10.7;7 Concluding Remarks and Prospects;197
10.8;References;197
11;8 Mitochondrial Electron Transport Complexes as Biochemical Target Sites for Insecticides and Acaricides;210
11.1;1 The Mitochondrial Electron Transport Chain;210
11.2;2 NADH:ubiquinone Oxidoreductase (Complex I);214
11.3;3 Ubihydroquinone:cytochrome c Oxidoreductase;219
11.4;4 The Respiratory Chain as Insecticide Target Site– Summary and Outlook;224
11.5;References;225
12;9 Inhibition of Programmed Cell Death by Baculoviruses: Potential in Pest- Management Strategies;230
12.1;1 Introduction;230
12.2;2 The Baculoviruses;233
12.3;3 Molecular Basis of Apoptosis;235
12.4;4 Conclusions;241
12.5;References;242
13;10 Plant Natural Products as a Source for Developing Environmentally Acceptable Insecticides;248
13.1;1 Introduction;248
13.2;2 From Pyrethrum to Synthetic Pyrethroids;249
13.3;3 Azadirachtin and Related Limonoids from the Meliaceae;249
13.4;4 Acetogenins from the Annonaceae;252
13.5;5 Alkaloids from Stemonaceae;253
13.6;6 Napthoquinones from the Scrophulariaceae;254
13.7;7 Rocaglamides from Aglaia (Meliaceae);255
13.8;8 Monoterpenoids from Plant Essential Oils;256
13.9;9 Conclusions;257
13.10;References;258
14;11 Essential Oils as Biorational Insecticides–Potency and Mode of Action;262
14.1;1 Introduction;262
14.2;2 Essential Oils Activities on Insect Pests;263
14.3;3 Efficacy of Essential Oils as Fumigants for the Control of Stored- Product Insects;264
14.4;4 Insecticidal Mode of Action of Essential Oil-Toxicity;266
14.5;5 Concluding Remarks;272
14.6;References;273
15;12 Insect Cell Lines as Tools in Insecticide Mode of Action Research;276
15.1;1 Introduction;276
15.2;2 Insect Cell Cultures;278
15.3;3 Endocrine Strategies;280
15.4;4 Insect-Specific Metabolic Pathways with Chitin and Cuticle Synthesis;293
15.5;5 Other Insect Targets Related to the Insect Neurological/ Nerve, Energy Metabolism and Muscle System;300
15.6;6 Insect Cell Lines as Proxies for Insecticidal Proteins;301
15.7;7 Suitability of Insect Cell Lines as Sentinels for Environmental Toxicity and Chemistry;303
15.8;8 Elucidation of Insecticide Resistance Mechanisms Using Insect Cell Lines;304
15.9;9 Conclusions;306
15.10;References;307
16;Index;318