Bioactive Heterocyclic Compound Classes

Agrochemicals
1. Auflage 2012
ISBN: 978-3-527-33396-7
Verlag: Wiley VCH Verlag GmbH

Buch, Englisch, 286 Seiten, Format (B × H): 177 mm x 254 mm, Gewicht: 732 g

Reihe: Bioactive Heterocyclic Compound Classes

The chemistry of heterocycles is an important branch of organic chemistry. This is due to the fact that a large number of natural products,
e. g. hormones, antibiotics, vitamins, etc. are composed of heterocyclic structures. Often, these compounds show beneficial properties and are
therefore applied as pharmaceuticals to treat diseases or as insecticides, herbicides or fungicides in crop protection. This volume presents important agrochemicals. Each of the 21 chapters covers in a concise manner one class of heterocycles, clearly structured as follows:

* Structural formulas of most important examples (market products)
*Short background of history or discovery
* Typical syntheses of important examples
* Mode of action
* Characteristic biological activity
* Structure-activity relationship
* Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.)
* References

A valuable one-stop reference source for researchers in academia and industry as well as for graduate students with career aspirations in the
agrochemical chemistry.

Autoren/Hrsg.

Lamberth, Clemens

Dinges, Jürgen

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie Pharmaindustrie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Naturwissenschaften Chemie Organische Chemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Technologie der land- und forstwirtschaftlichen Chemikalien

Inhaltsverzeichnis

IINTRODUCTIONTHE SIGNIFICANCE OF HETEROCYCLES FOR PHARMACEUTICALS AND AGROCHEMICALSIntroductionHeterocycles as Framework of Biologically Active CompoundsFine-Tuning the Physicochemical Properties with HeterocyclesHeterocycles as ProdrugsHeterocycles as PeptidomimeticsHeterocycles as Isosteric Replacement of Functional GroupsHeterocycles as Isosteric Replacement of Alicyclic RingsHeterocycles as Isosteric Replacement of other Heterocyclic RingsPART I: HerbicidesTRIAZINE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationships PYRIMIDINYL AND TRIAZINYLSULFONYLUREA HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship ACETOHYDROXYACID SYNTHASE INHIBITING TRIAZOLOPYRIMIDINE HERBICIDES Introduction HistorySynthesisMode of Action Biological Activity Structure?Activity Relationship HPPD-INHIBITING BENZOYLPYRAZOLE HERBICIDES IntroductionHistory SynthesisMode of ActionBiological Activity Structure?Activity Relationship PYRIDYLOXYPHENOXYPROPIONATE HERBICIDES: INHIBITORS OF ACETYL-COA CARBOXYLASEIntroduction HistorySynthesis Mode of Action Biological Activity Structure?Activity Relationships IMIDAZOLINONE HERBICIDESIntroduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PROTOPORPHYRINOGEN-IX-OXIDASE-INHIBITING URACIL HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship Part II: Fungicides BENZIMIDAZOLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship MORPHOLINE FUNGICIDES FOR THE TREATMENT OF POWDERY MILDEW Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship STEROL BIOSYNTHESIS INHIBITING TRIAZOLE FUNGICIDESIntroduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship METHIONINE BIOSYNTHESIS-INHIBITING ANILINOPYRIMIDINE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PHENYLPYRROLE FUNGICIDESIntroduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship BROAD-SPECTRUM FUNGICIDALLY ACTIVE PYRIMIDINYLDIOXY STROBILURINS INHIBITING THE RESPIRATORY CHAIN IntroductionHistory Synthesis Mode of Action Biological ActivityStructure?Activity Relationship PYRAZOLE CARBOXAMIDE FUNGICIDES INHIBITING SUCCINATE DEHYDROGENASE Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationships Part III: Insecticides AVERMECTIN INSECTICIDES AND ACARICIDES IntroductionHistory Synthesis Mode of ActionBiological Activity Structure?Activity Relationship PYRIDINE AND THIAZOLE-CONTAINING INSECTICIDES AS POTENT AGONISTS ON INSECT NICOTINIC ACETYLCHOLINE RECEPTORS Introduction HistorySynthesisMode of ActionBiological Activity Structure?Activity Relationship PYRAZOLE AND PYRIMIDINE ACARICIDES AND INSECTICIDES ACTING AS INHIBITORS OF MITOCHONDRIAL ELECTRON TRANSPORT AT COMPLEX I Introduction HistorySynthesis Mode of Action Biological Activity Structure?Activity Relationship PHENYLPYRAZOLE-CONTAINING FIPROLE INSECTICIDES Introduction History Synthesis Mode of ActionBiological ActivityStructure?Activity Relationship PYRAZOLYLPYRIDINE ACTIVATORS OF THE INSECT RYANODINE RECEPTOR Introduction History Synthesis Mode of ActionBiological ActivityStructure?Activity RelationshipsTETRONIC ACID INSECTICIDES AND ACARICIDES INHIBITING ACETYL-COA CARBOXYLASE Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship

Über Autor(innen)

Dinges, Jürgen
Jürgen Dinges obtained his M.S. degree in organic chemistry at the Technical University in Darmstadt, Germany, in 1988. He then joined the group of Prof. Frieder W. Lichtenthaler at the same university, where he received his Ph.D. degree in organic chemistry and chemical engineering in 1991. After being awarded a Feodor-Lynen scholarship from the Humboldt foundation, he spent 18 months as a postdoctoral fellow in the group of Prof. William G. Dauben at the University of California at Berkeley (USA). In 1993, Jürgen Dinges joined the department for biochemistry at Syntex, USA and since 1995 he is working in the pharmaceutical research department at Abbott Laboratories, USA. During his 18 years of industrial experience, Jürgen Dinges has specialized in drug discovery. In 2009, he was a guest editor for "Current Topics in Medicinal Chemistry" for a special issue on Parkinson's disease. He is an author of 17 publications and 23 patents and a co-inventor of more than 10 clinical drug development candidates.

Lamberth, Clemens
Clemens Lamberth is a senior team leader in the crop protection research department of Syngenta AG, Switzerland. He studied chemistry at the Technical University of Darmstadt, Germany, where he obtained his Ph.D. under the supervision of Prof. Bernd Giese in 1990. Subsequently, he spent one and a half years as a postdoctoral fellow in the group of Prof. Mark Bednarski at the University of California at Berkeley (USA). In 1992 Clemens Lamberth joined the agrochemical research department of Sandoz Agro AG, Switzerland, which is today, after two mergers, part of Syngenta Crop Protection AG. Since 20 years he is specialized in fungicide discovery. He was the organizer of the two-day session "New Trends for Agrochemicals" at the 2nd EUCHEMS congress in Torino, Italy, 2008. He is the author of 46 publications and 56 patents and the inventor of Syngenta's fungicide mandipropamid (Revus®, Pergado®).

Clemens Lamberth is a senior team leader in the crop protection research department of Syngenta AG, Switzerland. He studied chemistry at the Technical University of Darmstadt, Germany, where he obtained his Ph.D. under the supervision of Prof. Bernd Giese in 1990. Subsequently, he spent one and a half years as a postdoctoral fellow in the group of Prof. Mark Bednarski at the University of California at Berkeley, U.S.A. In 1992 Clemens Lamberth joined the agrochemical research department of Sandoz Agro AG, Switzerland, which is today, after two mergers, part of Syngenta Crop Protection AG. Since 20 years he is specialized in fungicide discovery. He was the organizer of the two-day session 'New Trends for Agrochemicals' at the 2nd EUCHEMS congress in Torino 2008. He is the author of 46 publications and 56 patents and the inventor of Syngenta's fungicide mandipropamid (Revus®, Pergado®).Jürgen Dinges obtained his M.S. degree in organic chemistry at the Technical University in Darmstadt, Germany in 1988. He then joined the group of Prof. Frieder W. Lichtenthaler at the same University, where he received his Ph.D. degree in organic chemistry and chemical engineering in 1991. After being awarded a Feodor-Lynen scholarship from the Humboldt foundation, he spent 18 months as a postdoctoral fellow in the group of Prof. William G. Dauben at the University of California at Berkeley, U.S.A. In 1993, Jurgen Dinges joined the department for biochemistry at Syntex, U.S.A. and since 1995 he is working in the pharmaceutical research department at Abbott Laboratories, U.S.A. In 2009, he was a guest editor for Current Topics in Medicinal Chemistry for a special issue on Parkinson?s disease. He is an author of 17 publications and 23 patents and a co-inventor of more than 10 clinical drug development candidates.