Smoller / Hiatt Dermatopathology: The Basics

1. Auflage 2009
ISBN: 978-1-4419-0024-1
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 156 Seiten

Dermatopathology: The Basics serves as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities. The reader is able to focus upon a single histologic observation, i.e., inflammatory conditions without epidermal changes, and use this as a starting point from which to build a differential diagnosis based upon pattern recognition. As each entity is addressed, there is a concise discussion of the basic clinical findings and epidemiologic associations. This is followed by a histologic description, highlighting areas that serve to discriminate between the entity under discussion and similar ones. Any immunologic studies that might augment the diagnostic sensitivity or specificity are discussed. Chapters are thematically based and consist of essential bullet points arranged in organized outlines allowing for easy access and direct comparison between entities. The salient histologic features are depicted with abundant high quality, full-color photomicrographs placed immediately adjacent to the appropriate histologic bullet points. This volume serves as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities. The elaborate pictorial documentation serves as an atlas of the commonest dermatologic disorders.  

Autoren/Hrsg.

Smoller, Bruce R.

Hiatt, Kim M.

Inhaltsverzeichnis

1;Preface;5
2;Acknowledgements;7
3;Contents;8
4;1 Normal Cutaneous Histology;12
4.1; Basic Skin Anatomy;12
4.2; Epidermis;12
4.2.1; Keratinocytes;12
4.2.1.1; Stratum Corneum;13
4.2.1.2; Stratum Granulosum;14
4.2.1.3; Stratum Spinosum;14
4.2.1.4; Stratum Basalis;15
4.2.2; Melanocytes;16
4.2.3; Langerhans Cells;17
4.2.4; Merkel Cells;19
4.2.5; Epidermal Appendages;19
4.2.5.1; Hair Follicles;19
4.2.5.2; Hair Follicle Anatomy (Anagen Phase);20
4.2.5.3; Sebaceous Glands;23
4.2.5.4; Eccrine Glands;24
4.2.5.5; Eccrine Ducts;25
4.2.5.6; Apocrine Glands;27
4.3; Basement Membrane Zone;27
4.3.1; Basal Keratinocyte;29
4.3.2; Lamina Lucida;29
4.3.3; Lamina Densa;30
4.3.4; Sub lamina Densa;30
4.4; Dermis;30
4.4.1; Vasculature;31
4.4.1.1; Collagens;33
4.4.1.2; Elastic Tissue;34
4.4.2; Nerves;35
4.4.3; Muscles;37
4.4.3.1; Dermal Dendrocytes;38
4.4.3.2; Lymphocytes;39
4.4.3.3; Mast Cells;39
4.4.3.4; Fibroblasts;40
4.5; Subcutaneous Fat;40
4.6; Skin of Special Sites;41
5;2 How to Maximize Information from a Skin Biopsy;47
5.1; Presumed Neoplastic Processes;48
5.1.1; What is the Differential Diagnosis?;48
5.1.2; Are the Margins Important?;49
5.1.3; Melanocytic Neoplasms;50
5.1.4; Keratinocytic Neoplasms;51
5.1.5; Adnexal Neoplasms;53
5.1.6; Dermal Neoplasms;56
5.1.7; Hematopoietic Neoplasms;59
5.2; Inflammatory Processes;60
5.2.1; Blistering Diseases;60
5.2.2; ''Dermatitis'' and ''Rash'';62
5.2.3; Infectious diseases;63
5.2.4; Connective Tissue Diseases;66
5.2.5; Direct Immunofluorescence;67
5.2.6; Vasculitis;67
5.2.7; Panniculitis;68
5.2.8; Alopecia;69
5.3; Miscellaneous Conditions;70
5.3.1; Presumed Connective Tissue Nevus, Anetoderma, Epidermal Nevus;70
5.4; Rules of Thumb;70
6;3 Special Stains in Dermatopathology;72
6.1; Histochemical Stains;72
6.2; Commonly Used Special Stains;72
6.3; Periodic Acid-Schiff (PAS);72
6.4; PAS Uses;73
6.5; Alcian Blue;73
6.6; Alcian Blue/Colloidal Iron Uses;74
6.7; Elastic von Gieson;74
6.7.1; Von Gieson Uses;74
6.8; Brown and Brenn Stain;75
6.9; Acid Fast Stain (AFB);75
6.10; Fite Stain;76
6.11; Giemsa;76
6.11.1; Giemsa Uses;76
6.12; Warthin-Starry;77
6.13; Massons Trichrome;77
6.14; Congo Red;78
6.15; Fontana Stain for Melanin;80
6.16; Chloroacetate Esterase;80
6.17; Perls;81
7;4 Immunopathology in Diagnostic*5ptDermatopathology;83
7.1; Tool Box: Antibody Panel;83
7.1.1; What Is a Tool Box?;83
7.2; Epithelial Markers;83
7.3; Mesenchymal Markers;86
7.4; Neuroectodermal Markers;87
7.5; Hematopoietic Markers;89
7.6; Miscellaneous Markers;91
7.7; Requirements for Interpretation;93
7.8; Pitfalls in Interpretation;93
7.9; Strategy for Immunopathology;94
7.10; Immunopathology;96
8;5 Differential Diagnosis of Normal Skin;100
8.1; Tinea Versicolor;101
8.2; Ichthyoses;103
8.3; Ichthyosis (X-Linked);103
8.4; Ichthyosis (Lamellar);104
8.5; Erythrasma;104
8.6; Ichthyosis Vulgaris;107
8.7; Pemphigus Foliaceus/Erythematosus;108
8.8; Vitiligo;109
8.9; Caf-Au-Lait Macule;111
8.10; Nevus Depigmentosus (Nevus Achromicus);111
8.11; Connective Tissue Nevus;113
8.12; Cutis Laxa;115
8.13; Morphea;117
8.14; Anetoderma (Macular Atrophy, Focal Dermal Elastolysis);120
8.15; Wrinkling due to Mid-dermal Elastolysis;121
8.16; Dermal Deposition Disorders;121
8.17; Amyloidosis;122
8.18; Localized Cutaneous Amyloidosis;122
8.19; Pretibial Myxedema;124
8.20; Sclerodema;126
8.21; Scleromyxedema;128
8.22; Nephrogenic Systemic Fibrosis;128
8.23; Conditions with Minimal Inflammation;131
8.24; Small Plaque (Guttate) Parapsoriasis (Digitate Dermatosis);131
8.25; Urticaria;133
8.26; Urticaria Pigmentosa;133
9;Further Reading;1
10;Index;1