Buch, Englisch, 228 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 630 g
Volume 10
Buch, Englisch, 228 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 630 g
ISBN: 978-0-12-820701-7
Verlag: Elsevier Health Sciences
Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered.
Zielgruppe
<p>Cancer researchers, medical scientists, clinicians, graduate students</p>
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
PART I General overview of the topic: An update1. General introduction about general mechanisms of resistance in cancer (hypoxia, efflux pumps, tumoral microenvironment) and use of chemosensitizers in association with drugs already in the market2. Clinical studies analysis3. Combination therapy4. Oncoimmunology
PART II Chemosensitizing agents with a validated mechanism of action5. pH regulators of the tumoral microenvironment6. Proton Pump Inhibitors (PPIs) and other pH buffering agents7. Selective hCA IX and XII inhibitors8. Epigenetic modulators9. Photosensitizing agents10. Efflux pumps and ABC transporter subfamily inhibitors (e.g., cyclosporin A, verapamil)11. Metalloproteinase inhibitors (e.g., ADAM17)12. Kinesin inhibitors13. Drug repurposing14. Innovative and putative targets for chemosensitizers15. Patent survey on chemosensitizers
PART III Chemosensitizing agents from natural sources16. Natural compounds as chemosensitizers: a lesson from plants17. Natural compounds: from food to clinic
PART IV Chemosensitizing agents: Computational tools and technological approaches18. Virtual screening and chemoinformatics of new library of chemosensitizers19. Nanostructures overcoming cancer resistance