Targeted Drug Delivery

1. Auflage 2022
ISBN: 978-3-527-34781-0
Verlag: Wiley-VCH GmbH

Buch, Englisch, 464 Seiten, Format (B × H): 179 mm x 250 mm, Gewicht: 1018 g

Reihe: Methods and Principles in Medicinal Chemistry

Targeted Drug Delivery

Novel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugs

Targeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting small molecules as well as peptide and macromolecular drugs, from prodrugs to drug conjugates to drug carriers and devices, helping readers to stay up to date on the latest developments in the field.

The following key topics are addressed: - Antibody conjugates, prodrugs, and suicide gene therapeutics
- Protac technology for selectively degrading target proteins
- Delivery of nucleic acid drugs
- Novel drug carriers, such as liposomes, vesicles, and nanoparticles
- Unmet medical needs for which there is a large market potential, such as viral infections and cancer

For chemists, pharmacologists, and professionals in the wider pharmaceutical industry, Targeted Drug Delivery is a comprehensive guide on how to solve the greatest challenge in treating many diseases: delivering a pharmaceutically active substance to the target tissue in the body.

Autoren/Hrsg.

Bachhav, Yogeshwar

Bachhav, Yogeshwar G.

Mannhold, Raimund

Buschmann, Helmut

Holenz, Jörg

Weitere Mitwirkende

Mannhold, Raimund

Buschmann, Helmut

Holenz, Jörg

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Technische Wissenschaften Technik Allgemein Nanotechnologie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

Basics of Targeted Drug Delivery
Addressing Unmet Medical Needs using Targeted Drug Delivery Systems: Emphasis on Nanomedicine-Based Applications
Nanocarriers Based Targeted Drug Delivery Systems: Small and Macromolecules
Liposomes as Targeted Drug Delivery Systems
Antibody-Drug Conjugates: Development and Applications
Gene-Directed Enzyme Prodrug Therapy (GDEPT) as a Suicide Gene Therapy Modality for Cancer Treatment
Targeted Prodrugs in Oral Drug Delivery
Exosomes for Drug Delivery Applications in Cancer and Cardiac Indications
Delivery of Nucleic Acids such as siRNA and mRNA using Complex Formulations
Application of PROTAC Technology in Drug Development
Metal Complexes as the Means or the End of Targeted Delivery for Unmet Needs
Formulation of Peptides for Targeted Delivery
Antibody-Based Targeted T Cell Therapies
Devices for Active Targeted Delivery: A Way to Control the Rate and Extent of Drug Administration
Drug Delivery to the Brain: Targeting Technologies to Delivery Therapeutics to Brain Lesions

Über Autor(innen)

Yogeshwar Bachhav is a pharmacist by training and holds a PhD in drug delivery systems from ICT, Mumbai (India). He has worked as research scientist for several years on a collaborative project between Pantec Biosolutions and Geneva University (Switzerland), and as formulation manager at Debiopharm Group, Lausanne (Switzerland). For the last 9 years he has been associated with AiCuris Anti-infective Cures AG (Germany) as in-charge for Pharmaceutical development of new drugs. In total, he has around 16 years of experience in the preformulation and formulation development of small molecules and peptides for oral, dermal and parenteral application and in drug substance manufacturing.