Bock / Goode Decoding the Genomic Control of Immune Reactions

1. Auflage 2007
ISBN: 978-0-470-06211-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 232 Seiten, E-Book

Reihe: Novartis Foundation Symposium

This book explores existing and potential strategies for using thegenome sequences of human, mouse, other vertebrates and humanpathogens to solve key problems in the treatment of immunologicaldiseases and chronic infections. The assembled genomesequences now provide important opportunities for solving theseproblems, but a major bottleneck is the identification of keysequences and circuits controlling the relevant immunereactions. This will require innovative, interdisciplinary andcollaborative strategies of a scale and complexity we are only nowbeginning to comprehend.
Specific problems addressed include the following:
* What kinds of information are we lacking to understand how thegenome sequence specifies the differentiation and response ofimmune system cells, and system behaviour such as immunologicalmemory and tolerance?
* Which genome sequences and cellular circuits cause or preventpathological immune responses to foreign pathogens, allergens orself-tissues?
* Which host and pathogen genome sequences and cellular circuitsexplain the failure of sterilizing immune responses tosophisticated human pathogens such as the agents of tuberculosis,malaria, metazoan parasites and chronic viruses?
Containing contributions from a range of leading experts in thefield, this book provides an important new perspective for clinicalimmunologists and basic researchers alike.

Autoren/Hrsg.

Bock, Gregory R.

Goode, Jamie A.

Inhaltsverzeichnis

Introduction (Chris Goodnow).
Transcriptional regulatory networks in macrophages. (David A.Hume, Christine A. Wells and Timothy Ravasi).
Discussion.
The RIKEN mouse transcriptome: lessons learned and implicationsfor the regulation of immune reactions (ChristianSchönbach).
Discussion.
Molecular pathways for lymphangiogenesis and their role in humandisease (Steven A. Stacker, Rae H. Farnsworth, Tara Karnezis,Ramin Shayan,.
Darrin P. Smith, Karri Paavonen, Natalia Davydova, CarolCaesar,.
Rachael Inder, Megan E. Baldwin, Bradley K. McColl, SallyRoufail,.
Richard A. Williams, Richard A. Hughes, Kari Alitaloand.
Marc G. Achen).
Discussion.
General discussion I.
Specifying the patterns of immune cell migration (Jason G.Cyster).
Discussion.
Human monogenic disorders that confer predisposition to specific infections (Capucine Picard, Laurent Abel andJean-Laurent Casanova).
Discussion.
The genetic control of susceptibility to Mycobacteriumtuberculosis (W. J. Britton, S. L. Fernando, B. M. Saunders,R. Sluyter and J. S. Wiley).
Discussion.
Th2 lymphoproliferative disorders resulting from defective LATsignalosomes (Bernard Malissen, Ying Wang, MichaelMingueneau and Marie Malissen).
Discussion.
Genetic analysis of systemic autoimmunity (Carola G.Vinuesa and Matthew C. Cook).
Discussion.
Genetic resistance to smallpox: lessons from mousepox(Gunasegaran Karupiah, Vijay Panchanathan, Isaac G. Sakalaand Geeta Chaudhri).
Discussion.
The AcB/BcA recombinant congenic strains of mice: strategies forphenotype dissection, mapping and cloning of quantitative traitgenes (Anny Fortin, Eduardo Diez, Janet E. Henderson, Jeffrey S.Mogil, Philippe Gros and Emil Skamene).
Discussion.
Genetic control of host-pathogen interactions in mice(Gundula Min-Oo, Mary M. Stevenson, Anny Fortin andPhilippe Gros).
Discussion.
Mycobacterium tuberculosis and its ability to resistimmunity (Douglas Young and Anne O'Garra).
Discussion.
Systems genetics: the next generation in genetics research?(Grant Morahan and Robert W. Williams).
Discussion.
Regulation of the immune system in metazoan parasite infections(Rick Maizels).
Discussion.
Closing remarks (Chris Goodnow).
Contributor Index.
Subject Index.

Über Autor(innen)

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