Bock / Goode Tissue Engineering of Cartilage and Bone

1. Auflage 2003
ISBN: 978-0-470-86423-4
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 262 Seiten, E-Book

Reihe: Novartis Foundation Symposium

Tissue engineering takes advantages of the combined use of culturedliving cells and three-dimensional scaffolds to reconstruct adulttissues that are absent or malfunctioning. This book bringstogether scientists and clinicians working on a variety ofapproaches for regenerating of damaged or lost cartilage and boneto assess the progress of this dynamic field.
In its early days, tissue engineering was driven by materialscientists who designed novel bio-resorbable scaffolds on which toseed cells and grow tissues. This ground-breaking work generatedhigh expectations, but there have been significant stumbling blocksholding back the widespread use of these techniques in the clinic.These challenges, and potential ways of overcoming them, are giventhorough coverage in the discussions that follow eachchapter.
The key questions addressed in this book include the following. Howgood must cartilage repair be for it to be worthwhile? What is thebest source of cells for tissue engineering of both bone andcartilage? Which are the most effective cell scaffolds? What arethe best preclinical models for these technologies? And when itcomes to clinical trials, what sort of outcome measures should beused? With contributions from some of the leading experts in thisfield, this timely publication will prove essential reading foranyone with an interest in the field of tissue engineering.

Autoren/Hrsg.

Bock, Gregory R.

Goode, Jamie A.

Inhaltsverzeichnis

Chair's Introduction (A. Caplan).
Tissue engineering of cartilage: do we need it, can we do it, isit good and can we prove it? (L. Lohmander).
Embryonic development and the principles of tissue engineering(A. Caplan).
The fundamentals of tissue engineering: scaffolds andbioreactors (G. Vunjak-Novakovic).
Tissue-engineered versus native cartilage: linkage betweencellular mechano-transduction and biomechanical properties (J. Lee,et al.).
From the preclinical model to the patient (E. Hunziker).
Mesenchymal stem cell therapy in joint disease (F. Barry).
Differentiated chondrocytes for cartilage tissue engineering (J.Huckle, et al.).
Mesenchymal stem cells and bioceramics: strategies to regeneratethe skeleton (H. Ohgushi, et al.).
Bone marrow stromal cells and their use in regenerating bone (R.Cancedda, et al.).
Studying the effect of different macrostructures on invitro cell behaviour and in vivo bone formation using atissue engineering approach (R. Dekker, et al.).
General discussion I
Cartilage repair with chondrocytes: clinical and cellularaspects (A. Lindahl, et al.).
Qualitative and quantitative in vivo assessment ofarticular cartilage using magnetic resonance imaging (E. O'Byrne,et al.).
Hyaluronan-based scaffolds (Hyalograft¯® C) inthe treatment of knee cartilage defects: preliminary clinicalfindings (A. Pavesio, et al.).
Quantitative analysis of repair tissue biopsies followingchondrocyte implantation (A. Hollander, et al.).
General discussion II: Tissue engineering using recombinanthuman BMP2.
Final discussion and summing-up.
Index of contributors.
Subject index.