Chadwick / Goode Cancer and Inflammation

1. Auflage 2004
ISBN: 978-0-470-85672-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 290 Seiten, E-Book

Reihe: Novartis Foundation Symposium

Chronic inflammation predisposes to some forms of cancer and thehost response to malignant disease shows several parallels withinflammation and wound healing. The cells involved in inflammationare detected in a range of common cancers, together with theinflammatory cytokines and members of the chemokine ligand/receptorsystems.
Neutralization or deletion of the gene for some inflammatorycytokines confers resistance to tumour induction and experimentalmetastasis. Over-expression of such cytokines in tumour cells mayenhance malignant potential. Certain chemokines are likely tosubvert antitumour immunity by favouring development of ineffectiveType 2 responses. Tumour cells may even utilize chemokine receptorsin homing to lymph nodes and other organs. Thus, the cells,cytokines and chemokines found in tumours are more likely tocontribute to tumour growth, progression and immunosuppression thanthey are to mount an effective host antitumour response.
This book draws together contributions from an international groupof scientists and clinicians from diverse disciplines, ranging fromepidemiology to immunology, cell biology, molecular oncology,molecular medicine and pharmacology to debate these and relatedissues. Topics covered include the epidemiological links betweencancer and inflammation, the parallels between inflammation andcancer, the role of inflammation in cancer, inflammatory genes asrisk factors for cancer initiation and progression, inflammationand cancer angiogenesis, and preventative and therapeuticstrategies.
Related Novartis Foundation symposia:
252 Generation and Effector Functions of RegulatoryLymphocytes
Chair: Jean-François Bach
254 Immunoinformatics: Bioinformatic Strategies for BetterUnderstanding of Immune Function
Chair: Hans-Georg Rammensee

Autoren/Hrsg.

Chadwick, Derek J.

Goode, Jamie A.

Inhaltsverzeichnis

Chair's Introduction (S. Gordon).
Inflammation and cancer: an epidemiological perspective (M.Thun, et al.).
Chemokine-based pathogenetic mechanisms in cancer (I. Conti, etal.).
General Discussion I.
Anti-TNF therapy of rheumatoid arthritis: what can we learnabout chronic disease? (M. Feldmann, et al.).
How do chemokine/chemokine receptor activations affecttumorigenesis? (A. Richmond, et al.).
Proinflammatory cytokines, immune response and tumourprogression (M. Spadaro and G. Forni).
General discussion II.
Lymphangiogenesis and tumour metastasis (J. Tille, et al.).
Infiltration of tumours by macrophages and dendritic cells:tumour-associated macrophages as a paradigm for polarized M2mononuclear phagocytes (A. Mantovani, et al.).
The influence of CD25¯+ cells on the generationof immunity to tumour cell-lines in mice (E. Jones, et al.).
Macrophages: modulators of breast cancer progression (E. Lin andJ. Pollard).
Chemokines: angiogenesis and metastases in lung cancer (R.Strieter, et al.).
Macrophage infiltration and angiogenesis in human malignancy (H.Knowles, et al.).
The role of inflammation for tumour growth and tumoursuppression (T. Blankenstein).
Cyclooxygenase 2: from inflammation to carcinogenesis (A.Ristimäki).
The inflammatory cytokine network of epithelial cancer:therapeutic implications (P. Szlosarek and F. Balkwill).
In vivo manipulation of DC migration and activation toelicit anti-tumour immunity (A. Vicari, et al.).
Final general discussion.
Concluding remarks (S. Gordon).
Index of contributors.
Subject Index.

Über Autor(innen)

The Novartis Foundation is an international scientific andeducational charity which promotes the study and general knowledgeof science and in particular encourages international co-operationin scientific research.
Chair: SIAMON GORDON, Sir William Dunn School ofPathology, University of Oxford, UK