Chadwick / Goode Development of the Cardiac Conduction System

1. Auflage 2003
ISBN: 978-0-470-86803-4
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 300 Seiten, E-Book

Reihe: Novartis Foundation Symposia

The pacemaking and conduction system (PCS) is vital for generatingand synchronizing the heart beat. Dysfunction of this systemcan be a direct cause of cardiac conduction disturbance,arrhythmias and sudden cardiac death. A wealth of information hasbeen collected over many years on the unique histological,morphological and phenotypic characteristics of specialized cardiactissues. The cellular and molecular mechanisms that governdevelopment of the PCS are now starting to be understood.
This book draws together contributions from an international andinterdisciplinary group of experts working on both basic andclinical aspects of cardiac development. It features reviews of thestructure and function of the developing PCS, discussion of themolecular and cellular mechanisms regulating embryologicaldevelopment of this system and studies on the fundamentalbasis of PCS pathology. The book also considers how noveltherapeutic interventions based on understanding of thedevelopmental biology of cardiac pacemaking and conduction tissuesmight ultimately impact on clinical medicine.

Autoren/Hrsg.

Chadwick, Derek J.

Goode, Jamie A.

Inhaltsverzeichnis

Chair's Introduction (R. Marwald).
The morphology of the cardiac condunction system (R. Andersonand S. Ho).
Development of the cardiac conduction system: a matter ofchamber development (A. Moorman and V. Crhistoffels).
Mouse models for cardiac conduction system development (A.Wessels, et al.).
Developmental transitions in cardiac conduction (M. Watanabe,et al.).
Gap junctional connexins in developing mouse cardiac conductionsystem (L. Miquerol, et al.).
His-Purkinje lineages and development (R. Gourdie, etal.).
The role of neural crest and epicardium-derived cells inconduction system formation (A. Gittenberger-de Groot, etal.).
Induction and patterning of the Purkinje fibre network (T.Mikawa, et al.).
The oldest, toughest cells in the heart (R. Thompson, etal.).
Transcriptional regulation in the mouse atrioventricularconduction system (A. Edwards, et al.).
Pattterning of the mouse conduction system (S. Rentschler, etal.).
Clinical pathology of the cardiac conduction system (S. Ho).
Cardiac conduction and arrhythmia: insights from Nkx2:5mutations in mouse and humans (P. Jay, et al.).
The genetic origin of atrio ventricular conduction disturbancein humans (D. Benson).
Defects in cardiac conduction system lineages and malignantarrhythmias: developmental pathways and disease (T. St. Armand etal).
Final general discussion.
Index of contributors.
Subject index.