Bradykinin

From Vasodilation to Neuroinflammation
Erscheinungsjahr 2025
ISBN: 978-0-443-28907-1
Verlag: Elsevier Science

Buch, Englisch, 528 Seiten, Format (B × H): 239 mm x 188 mm, Gewicht: 1089 g

Bradykinin: From Vasodilation to Neuroinflammation, the latest release in the Molecular Mediators in Health and Disease series is a comprehensive guide to the multi-functional peptide bradykinin and its impact across the human body. The early chapters provide an overview of the biosynthesis and metabolism of bradykinin, understanding its receptors and signaling pathways, and the therapeutic value of agonists and antagonists for targeting these. This book explores the role of bradykinin in vascular, renal, and brain function, as well as its influence on various conditions and diseases, including inflammation, pain, cardiovascular disease, renal disease, obesity, ischemic stroke, and infectious diseases, including Covid-19.

In addition to its foundational knowledge, the book includes extensive coverage of bradykinin biochemistry and molecular biology. It highlights the therapeutic potential of bradykinin, making it an ideal reference for researchers working in these fields. The book serves as an invaluable resource for understanding the complex roles of bradykinin and its applications in medical research and treatment.

Autoren/Hrsg.

Couture, Réjean

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

1. Introduction to bradykinin
Réjean Couture
2. Tracing the historical journey: milestones and highlights of bradykinin
Réjean Couture, Rahmeh Othman, Sébastien Talbot and Jean-Pierre Girolami
3. Kinin receptors and their signaling and regulation
Fredrik Leeb-Lundberg
4. Animal models for studying bradykinin receptors
Leonardo Martin, João Bosco Pesquero and Michael Bader
5. Peptide and nonpeptide ligands acting at bradykinin receptors
François Marceau, Xavier Charest-Morin and Lajos Gera
6. Bradykinin-related peptides and their receptors from nonmammalian vertebrates
Haixin Qin and Hang Fai Kwok
7. Bradykinin forming pathways and the pathogenesis of hereditary angioedema
Allen P. Kaplan
8. Bradykinin in ACEI and other drug-induced angioedema
Nancy J Brown
9. The kinins, a family of bioactive peptides that modulate inflammation
Carlos D. Figueroa
10. Bradykinin in pain
Robson da Costa, Marianne N. Manjavachi, Nara L.M. Quintão and Giselle F. Passos
11. Bradykinin in cardiovascular physiology and disease
François Alhenc-Gelas, Nadine Bouby and Christine Richer-Giudicelli
12. Tissue kallikrein in therapeutic angiogenesis: from basic science to clinical applications
Paolo Roberto Madeddu
13. Bradykinin in diabetes and obesity
Alexandre Budu and Ronaldo Carvalho Araujo
14. Bradykinin in ocular health and diseases
Menakshi Bhat, Réjean Couture and Elvire Vaucher
15. Kinin agonists as a means to increase blood-brain barrier permeability of drugs
Juliette Latulippe, David Fortin and Fernand Gobeil
16. Bradykinin’s role in Alzheimer’s: protection or damage?
Mariana Toricelli and Hudson Sousa Buck
17. Bradykinin receptors in neglected parasitic and viral diseases
Julio Scharfstein
18. Bradykinin in cancer
Gabriela Weirich Neculqueo and Maria Martha Campos

Über Autor(innen)

Couture, Réjean
Réjean Couture is currently Full Professor at the Department of Pharmacology and Physiology at the Faculty of Medicine, Université de Montréal in Canada. After completing a PhD in Pharmacology at University of Sherbrooke, Canada, he was awarded Fellowship Awards from the Medical Research Council of Canada (MRC) and the Fonds de la recherche en santé du Quebec (FRSQ) to pursue postdoctoral trainings in Pharmacology at Oxford University and in Neuroscience at McGill University.

He is the author of over 225 original articles, books and book chapters, including 90 directly on kinins. He has supervised close to 60 graduate and postdoctoral students, many of whom now hold significant academic and other positions throughout Canada and internationally.

He is known internationally for his seminal contributions in the field of Bradykinin and Substance P in pain and inflammation and in central autonomic control of blood pressure.