Buch, Englisch, 121 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 377 g
Buch, Englisch, 121 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 377 g
Reihe: Research and Perspectives in Neurosciences
ISBN: 978-3-642-04297-3
Verlag: Springer
biologyinneuronalprocessesandinbraindisorders. BartdeStrooper YvesChristen v Acknowledgments The editors wish to thank Jacqueline Mervaillie and Sonia Le Cornec for the organizationofthemeetingandMaryLynnGagefortheeditingofthebook. vii Contents Pro?lingthemicroRNAs. 1 KennethS. Kosik,ThalesPapagiannakopoulos,NaXu, KawtherAbu-Elneel,TsunglinLiu,andMinJeongKye TheWideVarietyofmiRNAExpressionPro?les intheDevelopingandMatureCNS. 9 MarikaKapsimali InteractionsbetweenmicroRNAsandTranscription FactorsintheDevelopmentandFunction oftheNervousSystem. 19 DavidJ. Simon AmicroRNAFeedbackCircuitinMidbrainDopamineNeurons. 27 AsaAbeliovich Fine-tuningmRNATranslationatSynapseswithmicroRNAs. 35 GerhardM. Schratt NeuronalP-bodiesandTransportofmicroRNA-Repressed mRNAs. 45 FlorenceRage CrosstalkbetweenmicroRNAandEpigeneticRegulation inStemCells. 57 KeithSzulwach,ShuangChang,andPengJin microRNAsinCNSDevelopmentandNeurodegeneration: InsightsfromDrosophilaGenetics. 69 StephenM. Cohen ix x Contents DrosophilaasaModelforNeurodegenerativeDisease: RolesofRNAPathwaysinPathogenesis. 79 NancyM. Bonini microRNAsinSporadicAlzheimer’sDiseaseandRelated Dementias. 91 Se´bastienS. He´bert,WimMandemakers,AikateriniS. Papadopoulou, andBartDeStrooper microRNADysregulationinPsychiatricDisorders. 99 BinXu,JosephA. Gogos,andMariaKarayiorgou Index. 119 Contributors Abeliovich Asa Columbia University Medical Center, 630 West 168th Street, Room15-405,NewYork,NY10032,USA,aa900@columbia. edu Abu-ElneelKawther NeuroscienceResearchInstitute,DepartmentofMolecular CellularandDevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA BoniniNancyM. UniversityofPennsylvania,306LeidyLaboratories,Depa- mentofBiology,Philadelphia,PA19104,USA,nbonini@sas. upenn. edu Chang Shuang Department of Human Genetics, Emory University School of Medicine,Atlanta,GA30322,USA CohenStephenM. TemasekLifeSciencesLaboratoryLimited,1ResearchLink National University of Singapore, 117604 Singapore, SINGAPORE, steve@ tll. org. sg DeStrooperBart Centerforhumangenetics,K. U. LeuvenandDepartmentof molecularanddevelopmentalgenetics,VIBLeuven,BELGIUM GogosJosephA. DepartmentofPhysiology&CellularBiophysicsandDepa- mentofNeuroscience,ColumbiaUniversity,NewYork,USA He´bert Se´bastien S. Centre de Recherche du CHUQ (CHUL), Axe Neur- ciences,Universite´Laval,De´partementdeBiologieme´dicale,2705Boul. Laurier, LocalRC-9800,Que´bec,Qc,Canada,sebastien. hebert@crchul. ulaval. ca JinPeng DepartmentofHumanGeneticsandGraduatePrograminGeneticsand MolecularBiology,EmoryUniversitySchoolofMedicine,Atlanta,GA30322, USA,pjin@genetics. emory. edu ´ ´ ´ ´ KapsimaliMarika INSERMU784,GenetiqueMoleculaireduDeveloppement, ´ Ecole Normale Superieure, 46 rue d´Ulm, 75230 PARIS Cedex 05 FRANCE, kapsimal@biologie. ens. fr xi xii Contributors Karayiorgou Maria Columbia University, Department of Psychiatry, 1051 RiversideDrive,Unit#28,NewYorkNY10032,USA,mk2758@columbia. edu Kosik Kenneth S. Neuroscience Research Institute, Department of Molecular Cellular and Developmental Biology, University of California Santa Barbara, BiologyII,Room6139A,SantaBarbara,CA93106,USA,kosik@lifesci. ucsb.
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Profiling the microRNAs.- The Wide Variety of miRNA Expression Profiles in the Developing and Mature CNS.- Interactions between microRNAs and Transcription Factors in the Development and Function of the Nervous System.- A microRNA Feedback Circuit in Midbrain Dopamine Neurons.- Fine-tuning mRNA Translation at Synapses with microRNAs.- Neuronal P-bodies and Transport of microRNA-Repressed mRNAs.- Crosstalk between microRNA and Epigenetic Regulation in Stem Cells.- microRNAs in CNS Development and Neurodegeneration: Insights from Drosophila Genetics.- Drosophila as a Model for Neurodegenerative Disease: Roles of RNA Pathways in Pathogenesis.- microRNAs in Sporadic Alzheimer’s Disease and Related Dementias.- microRNA Dysregulation in Psychiatric Disorders.
