Buch, Englisch, 496 Seiten, Format (B × H): 222 mm x 284 mm, Gewicht: 1719 g
The Molecular Pathology of Dementia and Movement Disorders
Buch, Englisch, 496 Seiten, Format (B × H): 222 mm x 284 mm, Gewicht: 1719 g
ISBN: 978-1-4051-9693-2
Verlag: Wiley
Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, ±-synuclein and TDP-43) and in the extracellular compartments (e.g. ²-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts
Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis.
This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
Weitere Infos & Material
Part 1 Introduction: Basic Mechanisms of Neurodegeneration.
1 Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders (Dennis Dickson).
2 Cell Death and Neurodegeneration (Violetta N. Pivtoraiko and Kevin A. Roth).
3 Oxidative Stress and Balance in Neurodegenerative Diseases (George Perry, Siddhartha Mondragón-Rodríguez, Akihiko Nunomura, Xiongwei Zhu, Paula I. Moreira and Mark A. Smith).
4 Protein Aggregation in Neurodegeneration (Adriano Aguzzi and Veronika Kana).
5 Protein Degradation in Neurodegeneration: The Ubiquitin Pathway (Lynn Bedford, Robert Layfield, Nooshin Rezvani, Simon Paine, James Lowe and R. John Mayer).
6 Genetics of Neurodegeneration (John Hardy).
7 Transgenic Animal Models of Proteinopathies (Naruhiko Sahara, Heather Melrose, Simon D'Alton and Jada Lewis).
Part 2 Alzheimer's Disease and Aging.
8 Clinical Aspects of Alzheimer's Disease (David Knopman).
9 Genetics of Alzheimer's Disease (Lars Bertram and Rudolph E. Tanzi).
10 Neuropathology of Alzheimer's Disease and its Variants (Charles Duyckaerts and Dennis Dickson).
11 Aß Amyloid Production (Colin L. Masters and Konrad Beyreuther).
12 Elimination of Amyloid-ß from the Brain, its Failure in Alzheimer's Disease and Implications for Therapy (Roy O. Weller, Seth Love and James A.R. Nicoll).
Part 3 Tauopathies.
13 Introduction to the Tauopathies (Michel Goedert).
14 Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 (Bernardino Ghetti, Zbigniew K. Wszolek, Bradley F. Boeve, Salvatore Spina and Michel Goedert).
15 Progressive Supranuclear Palsy and Corticobasal Degeneration (Dennis Dickson, Jean-Jaques Hauw, Yves Agid and Irene Litvan).
16 Pick's Disease (David G. Munoz, Huw R. Morris and Martin Rossor).
17 Argyrophilic Grain Disease (Markus Tolnay and Heiko Braak).
18 Parkinsonism-Dementia Complex of Guam (Kiyomitsu Oyanagi, Tomoyo Hashimoto and Mineo Yamazaki).
19 Postencephalitic Parkinsonism (Kurt A. Jellinger).
Part 4 Synucleinopathies.
20 Introduction to [alpha]-Synucleinopathies (Maria Grazia Spillantini).
21 Parkinson's Disease (Kurt A. Jellinger).
22 Dementia with Lewy Bodies and Parkinson's Disease Dementia (Paul G. Ince).
23 Lewy Bodies in Conditions other than Disorders of [alpha]-Synuclein (Coro Paisán-Ruiz, Laura Parkkinen and Tamas Revesz).
24 Multiple System Atrophy (Janice L. Holton, Andrew J. Lees and Tamas Revesz).
Part 5 Trinucleotide Repeat Disorders.
25 Introduction to Trinucleotide Repeat Diseases (H. Brent Clark).
26 Huntington's Disease (John C. Hedreen and Raymund A.C. Roos).
27 Spinocerebellar Ataxias (Hidehiro Mizusawa, H. Brent Clark and Arnulf H. Koeppen).
28 Friedreich's Ataxia (Arnulf H. Koeppen).
29 Dentatorubral-pallidoluysian Atrophy (Hitoshi Takahashi, Mitsunori Yamada and Shoji Tsuji).
30 Spinal and Bulbar Muscular Atrophy (Gen Sobue, Hiroaki Adachi and Masahisa Katsuno).
Part 6 Prion Disorders.
31 Introduction to Prion Disorders (Adriano Aguzzi and Veronika Kana).
32 Sporadic Creutzfeldt-Jakob Disease (Herbert Budka, Mark W. Head, James W. Ironside, Pierluigi Gambetti, Piero Parchi and Fabrizio Tagliavini).
33 Genetic Creutzfeldt-Jakob Disease (Piero Parchi, Pierluigi Gambetti and Sabina Capellari).
34 Fatal Familial and Sporadic Insomnia (Piero Parchi, Sabina Capellari and Pierluigi Gambetti).
35 A New Prion Disease: Protease-Sensitive Prionopathy (Pierluigi Gambetti, Gianfranco Puoti, Qingzhong Kong and Wenquan Zou).
36 Variant Creutzfeldt-Jakob Disease (James W. Ironside, Mark W. Head and Robert G. Will).
37 Gerstmann-Sträussler-Scheinker Disease (Bernardino Ghetti, Fabrizio Tagliavini, Gabor Kovacs and Pedro Piccardo).
38 Kuru (Catriona Ann McLean).
39 Iatrogenic Creutzfeldt-Jakob Disease (James W. Ironside, Richard S.G. Knight and Mark W. Head).
Part 7 Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis/Motor Neuron Di
