Dupré / Hébert / Jockers GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

2012
ISBN: 978-94-007-4765-4
Verlag: Springer Netherland
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 63, 300 Seiten, eBook

Reihe: Subcellular Biochemistry

Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.

Zielgruppe

Research

Autoren/Hrsg.

Dupré, Denis J.

Hébert, Terence E.

Jockers, Ralf

Inhaltsverzeichnis

1. ER-bound steps in the biosynthesis of G protein-coupled receptors; Christian Nanoff and Michael Freissmuth 2. Role of chaperones in G protein coupled receptor signalling complex assembly; Denis J. Dupré, Maha M. Hammad, Patrick Holland and Jaime Wertman3. GPCR oligomerization: contribution to receptor biogenesis: Kathleen Van Craenenbroeck4. The functional size of GPCRs- monomers, dimers or tetramers?; Darlaine Pétrin and Terence E. Hébert5. Regulation of post-Golgi traffic of G protein-coupled receptors; Guangyu Wu 6. Regulated GPCR trafficking to the plasma membrane: general issues and the CCR5 chemokine receptor example; Hamasseh Shirvani, Gabriel Gätà and Stefano Marullo7. Regulatory Processes Governing the Cell Surface Expression of LH and FSH Receptors; Deborah L. Segaloff8. Chaperone-mediated assembly of G protein complexes; Barry M. Willardson and Christopher M. Tracy 9. Synthesis and assembly of G protein bg dimers: comparison of in vitro and in vivo studies; Jane Dingus and John D. Hildebrandt 10. Preferential assembly of G-abg complexes directed by the g subunits; Janet D. Robishaw11. G Protein Trafficking; Philip B. Wedegaertner 12. Differential assembly of GPCR signaling complexes determines signaling specificity; Pascal Maurice , Abla Benleulmi-Chaachoua & Ralf Jockers  13. GPCR and voltage-gated calcium channels (VGCC) signaling complexes; Christophe Altier 14. Pharmacological chaperones correct misfolded GPCRs and rescue function: trafficking as a therapeutic target; Guadalupe Maya-Núñez, Alfredo Ulloa-Aguirre, Jo Ann Janovick, P. Michael Conn