Buch, Englisch, 516 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 797 g
From Molecular Discoveries to Cancer Therapy
Buch, Englisch, 516 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 797 g
ISBN: 978-1-4419-2398-1
Verlag: Springer
Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. “The Kinetochore: from Molecular Discoveries to Cancer Therapy” presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and “model” eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
- Naturwissenschaften Biowissenschaften Zellbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
- Naturwissenschaften Biowissenschaften Molekularbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
Weitere Infos & Material
Centromeres and Kinetochores: An Historical Perspective.- The Basics of Chromosome Segregation.- The Centromere.- Neocentromeres.- Human Artificial Centromeres: Assembly of Functional Centromeres on Human Artificial Chromosomes.- Kinetochore Composition, Formation, and Organization.- Evolution of Centromeres and Kinetochores: A Two-Part Fugue.- Mitotic Spindle Assembly Mechanisms.- Kinetochore-Microtubule Interactions.- Post-Translational Modifications that Regulate Kinetochore Activity.- The Role of the Kinetochore in Spindle Checkpoint Signaling.- Kinetochore Regulation of Anaphase and Cytokinesis.- Roles of Centromeres and Kinetochores in Meiosis.- The Kinetochore-Cancer Connection.- The Kinetochore as Target for Cancer Drug Development.
