Goswami / Pandi-Perumal / Thorpy Narcolepsy

A Clinical Guide
2010
ISBN: 978-1-4419-0854-4
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 330 Seiten, eBook

Narcolepsy serves as a prototype of how the interaction of high quality clinical research and groundbreaking basic science can collaborate to defne the cause of a disease and change forever how we evaluate and treat it. There is scarcely a topic in this book that would have been covered in the same way 10 years ago as it is d- cussed today. We are also fortunate that many of the players in this dramatic tu- around have contributed to this volume, so that the result is a tapestry of the events that have transformed the feld over the last decade that is both authentic and detailed. The frst section of the book provides much of the basic science background. As described in the frst two chapters, the dramatic convergence of lines of evidence from two different laboratories frst demonstrated in 1999 that narcolepsy is a disease of loss of neurotransmission by lateral hypothalamic neurons making the peptides that have been called orexins or hypocretins. These fndings did much to clarify and unify a feld that had puzzled for decades over the fundamental nature of this puzzling disease, as refected in the chapters that review its epidemiology and neuroanatomical and imaging fndings.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Goswami, Meeta

Pandi-Perumal, S. R.

Thorpy, Michael J.

Inhaltsverzeichnis

Foreword
Clifford C. Saper, MD, PhD

Preface
Editors

Credits and Acknowledgements
Editors

SECTION I: ETIOLOGY

1. Narcolepsy: Genetic predisposition and pathophysiology
Emmanuel Mignot, MD, PhD.

2. Animal models of narcolepsy: Developments, findings, and perspectives
Christopher M. Sinton, PhD.

3. Neuroimaging of narcolepsy
Eric A. Nofzinger, MD.

SECTION II: CLINICAL CONSIDERATIONS

4. Epidemiology of narcolepsy
Lauren Hale, PhD.

5. Narcolepsy in Childhood
Shalini Paruthi, MD. & Suresh Kotagal, MD.

6. Narcolepsy in the Older Adult
Hrayr Attarian, MD.

7. Diurnal and nocturnal sleep in narcolepsy with cataplexy
Yves Dauvilliers, MD, PhD & Giuseppe Plazzi, MD, PhD

8. Hypnagogic Hallucinations and Sleep Paralysis
Armando D’Agostino, MD & Ivan Limosani, MD.

9. REM sleep behaviour disorder in narcolepsy with cataplexy.
Giuseppe Plazzi, MD, PhD & Yves Dauvilliers, MD, PhD.

10. Narcolepsy and other comorbid medical illnesses
Lori A. Panossian, MD & Alon Y. Avidan, MD, MPH.

11. Humor processing in human narcolepsy with cataplexy
Aurélie Ponz & Sophie Schwartz, PhD.

12. Dreams in patients with narcolepsy
Michael Schredl

13. Psychoanalysis and narcolepsy
James F Pagel, MS, MD & Lawrence Scrima, PhD

14. Symptomatic narcolepsy or hypersomnia, with and without hypocretin (orexin) deficiency
Kanbayashi T, Nakamura M, Shimizu T, & Seiji Nishino, MD, PhD.

15. Hypersomnias other than narcolepsy: Differential diagnosis
Michel Billiard, MD.

SECTION III: PSYCHOSOCIALCONSIDERATIONS

16. Psychosocial impact of narcolepsy in children and adolescents
Gregory Stores MA, MD, DPM, FRCPsych, FRCP.

17. Quality of life and psychosocial issues in narcolepsy
Meeta Goswami BDS, MPH, PhD.

18. Narcolepsy, Intimacy and Sexuality
Gila Lindsley, Ph.D.

19. Narcolepsy, driving and traffic safety
Claire EHM Donjacour, Monique AJ Mets, Joris C Verster, PhD.

20. Memory and Cognition in Narcolepsy
Christian Bellebaum, & Irene Daum, PhD.

21. Medico-legal aspects of disability in narcolepsy

Francesca Ingravallo and Giuseppe Plazzi

22. Narcolepsy and mental health
John Shneerson, MA, DM, MD, FRCP, FCCP
SECTION IV: MANAGEMENT
23. Overview of management of narcolepsy

Seiji Nishino, MD, PhD.

24. Modes of action of drugs related to narcolepsy: Pharmacology of wake-promoting compounds and anticataplectics
Seiji Nishino, MD, PhD & Nozomu Kotorii, MD, PhD.

25. Modafinil/ Armodafinil in the Treatment of Narcolepsy
Michael Thorpy, MD

26. Sodium oxybate in the treatment of narcolepsy
Geert Mayer

27. Emerging treatments for narcolepsy
Meredith Broderick MD & Christian Guilleminault MD, BiolD.

28. Non-pharmacologic Treatments of Narcolepsy
Renee Monderer, MD, Shelby Freedman Harris, PsyD, CBSM. &
Michael J. Thorpy, MD.

Über Autor(innen)

Meeta Goswami, BDS, PhD, MPH, has been the director of the Narcolepsy Institute since its inception in 1985 and serves as an Assistant Professor of Neurology, Albert Einstein College of Medicine. Her general area of research interest includes narcolepsy and psychosocial issues.

S.R. Pandi-Perumal, M.Sc, is the President and Chief Executive Officer of Somnogen Inc, a New York Corporation. He is a well-recognized sleep researcher both nationally and internationally, and has authored many publications. His general area of research interest includes sleep and biological rhythms. He is a well-known editor in the field of sleep medicine and has edited over 15 volumes dealing with various sleep-related topics.

Michael J Thorpy, MD, has won many awards for his research including one of the sleep field's highest honors: the Nathaniel Kleitman Award. He is a well-published researcher and a board-certified sleep physician. He serves as a Professor of Neurology at Albert Einstein College of Medicine and the Director of the Sleep-Wake Disorders Center at Montefiore Medical Center, Bronx, New York.