Hardt / Schönfeld Microfluidic Technologies for Miniaturized Analysis Systems

1. Auflage 2007
ISBN: 978-0-387-68424-6
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 616 Seiten

Reihe: MEMS Reference Shelf

This book addresses Lab-on-a-Chip devices. It focuses on microfluidic technologies that have emerged in the past decade. Coverage presents a comprehensive listing of the most promising microfluidic technologies in the Lab-on-a-Chip field. It also details technologies that can be viewed as toolboxes needed to set up complex Lab-on-a-Chip systems.

Autoren/Hrsg.

Hardt, Steffen

Schönfeld, Friedhelm

Inhaltsverzeichnis

1;Preface;6
2;Table of Contents;9
3;List of Contributors;19
4;Chapter 1 Microfluidics: Fundamentals and Engineering Concepts;22
4.1;1. Introduction;22
4.2;2. Essentials of Fluidic Transport Phenomena at Small Scales;24
4.3;3. Scaling Analysis;35
4.4;4. System/Engineering Concepts and Design Approaches for Microfluidics;52
4.5;References;70
5;Chapter 2 Electrohydrodynamic and Magnetohydrodynamic Micropumps;80
5.1;1. Introduction;80
5.2;2. Electric Forces in the Bulk: Injection, Conduction, and Induction EHD Pumps;87
5.3;3. Electric Forces in the Diffuse Layer: Electroosmotic and AC/ IC Electroosmotic Pumps;106
5.4;4. Magnetic Forces: DC and AC MHD Pumps;120
5.5;5. Comparisons and Conclusions;128
5.6;Acknowledgments;132
5.7;References;132
6;Chapter 3 Mixing in Microscale;138
6.1;1. Introduction;138
6.2;2. Mass Transport in Microscale;139
6.3;3. Micromixers Based on Molecular Diffusion;146
6.4;4. Micromixers Based on Chaotic Advection;160
6.5;5. Active Micromixers;167
6.6;References;170
7;Chapter 4 Control of Liquids by Surface Energies;177
7.1;1. Introduction;177
7.2;2. Capillary Model;179
7.3;3. Plane Substrates with Wettability Patterns;184
7.4;4. Wetting of Topographically Patterned Substrates;201
7.5;5. Summary and Outlook;216
7.6;Acknowledgment;217
7.7;References;217
8;Chapter 5 Electrowetting: Thermodynamic Foundation and Application to Microdevices ;223
8.1;1. Introduction;223
8.2;2. Theoretical Background;225
8.3;3. Electrowetting and Its Recent Variations;240
8.4;4. Microfluidic Device Using Electrowetting;247
8.5;5. Summary;256
8.6;Acknowledgments;256
8.7;References;256
9;Chapter 6 Magnetic Beads in Microfluidic Systems – Towards New Analytical Applications;260
9.1;1. Introduction;260
9.2;2. Types of Magnetic Beads;261
9.3;3. Forces on Magnetic Beads;263
9.4;4. Magnetic Bead Separation;265
9.5;5. Magnetic Bead Transport;269
9.6;6. Magnetic Beads as Labels for Detection;272
9.7;7. Separation and Mixing Using Magnetic Supraparticle Structures;276
9.8;8. Magnetic Beads as Substrates for Bio-assays;277
9.9;9. Magnetic Beads in Droplets;281
9.10;10. Conclusion;284
9.11;Acknowledgements;285
9.12;References;285
10;Chapter 7 Manipulation of Microobjects by Optical Tweezers;294
10.1;1. Introduction;294
10.2;2. Single-Particle Manipulation with a Focused Laser Beam;295
10.3;3. Multiparticle Manipulation Techniques;307
10.4;4. Optically Driven Microfluidic Components;316
10.5;5. Bio-manipulation Based on Optical Tweezers;324
10.6;6. Conclusions and Outlook;328
10.7;References;328
11;Chapter 8 Dielectrophoretic Microfluidics;334
11.1;1. Introduction;334
11.2;2. Quantification of Dielectrophoretic Micro-Fluidics;335
11.3;3. Microfluidic Applications of Dielectrophoresis;348
11.4;4. Conclusion;369
11.5;References;370
12;Chapter 9 Ultrasonic Particle Manipulation;375
12.1;1. Introduction;375
12.2;2. Theory;376
12.3;3. Transduction Techniques;386
12.4;4. Applications of Ultrasonic Particle Manipulation;391
12.5;5. The Future of Ultrasonic Particle Manipulation;401
12.6;Acknowledgement;401
12.7;References;401
13;Chapter 10 Electrophoresis in Microfluidic Systems;411
13.1;1. Introduction;411
13.2;2. Electrophoresis in Microfabricated Systems;414
13.3;3. Applications of Microchip Electrophoresis;425
13.4;4. Summary and Outlook;432
13.5;References;433
14;Chapter 11 Chromatography in Microstructures;457
14.1;1. Introduction;457
14.2;2. Examples of Chromatography on Microchips;463
14.3;3. Conclusions;483
14.4;References;484
15;Chapter 12 Microscale Field-Flow Fractionation: Theory and Practice;488
15.1;1. Introduction;488
15.2;2. Background and Theory;489
15.3;3. Miniaturization Effects in FFF;497
15.4;4. Microscale Electrical FFF;502
15.5;5. Microscale Cyclical Electrical FFF;511
15.6;6. Microscale Dielectrophoretic FFF;518
15.7;7. Microscale Thermal FFF;522
15.8;8. Miniaturized Flow FFF;524
15.9;9. Microscale Acoustic FFF;525
15.10;10. Other Microscale FFF Efforts;526
15.11;11. Nanoscale FFF;530
15.12;12. Conclusion;532
15.13;Acknowledgements;533
15.14;References;533
16;Chapter 13 Nucleic Acid Amplification in Microsystems;539
16.1;1. General Elements of Amplification;539
16.2;2. Micro–Macro Comparison;542
16.3;3. Microfluidic Realization Methods;546
16.4;4. Alternative Protocols to PCR;567
16.5;5 . Conclusion;570
16.6;References;571
17;Chapter 14 Cytometry on Microfluidic Chips;584
17.1;1. Introduction;584
17.2;2. Design of Microfluidic Flow Cytometers;587
17.3;3. Detection Concepts for Ultrasensitive Cytometry;595
17.4;4. Perspectives for Biotechnology;607
17.5;5. Conclusion;613
17.6;References;613
18;Index;621
19;ABOUT THE COVER;630