Buch, Englisch, 237 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 5029 g
Reihe: Progress in Drug Research
Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases
Buch, Englisch, 237 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 5029 g
Reihe: Progress in Drug Research
ISBN: 978-3-319-63952-9
Verlag: Springer International Publishing
This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
- Naturwissenschaften Biowissenschaften Proteinforschung
- Naturwissenschaften Chemie Organische Chemie Biochemie
- Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
- Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
Weitere Infos & Material
preliminary ToC
1 Introduction.- References.- 2 Nomenclature.- References .- 3 Syntheses.- 3.1 Syntheses of acridine ring and its precursors.- 3.2 Acridine-peptide conjugates .- 3.3 Acridines as catalysts.- References.- 4.- Interactions of acridines with nucleic acids .- 4.1 DNA.- 4.2 DNA Quadruplexes.- 4.3 RNA.- 4.4 PNA .- 4.5 Acridine metal complexes.- 4.6 Structural aspects of nucleic acid binding.- References.- 5 Interactions with proteins.- 5.1 Interactions with nucleic acids processing proteins.- 5.1.1 Topoisomerases .- 5.1.2 Transcription factors.- 5.1.3 RecA protein.- 5.1.4 Telomerase.- 5.2 Interactions with other proteins.- 5.3 Structural aspects of acridine interactions with proteins.- References.- 6 Applications for treatment of neurodegenerative diseases.- 6.1 Alzheimer’s disease.- 6.1.1 Multitargeted strategy in AD.- 6.2 Parkinson’s disease.- 6.3 Prion diseases.- 6.4 Other neurodegenerative diseases.- References.- 7 Some application of selective toxicities of acridines.- 7.1 Antiprotozoal drug.- 7.2 Cancer treatment.- 7.3 Antibacterial drug.- 7.4 Pharmacokinetics and metabolism of acridine drugs.- References.- 8 Acridine on dendrimeric carriers.- 8.1 Application for drug and gene delivery.- References.- 9 Acridines used for staining.- References.- 10 Miscellaneous.- References.- 11 Conclusions and outlook
