Stem Cells and Neuronal Development in the Adult Brain
Buch, Englisch, 544 Seiten, Format (B × H): 156 mm x 234 mm
ISBN: 978-0-19-517971-2
Verlag: Oxford University Press
The first and so far only comprehensive overview of one of the most exciting areas of research in neuroscience
- Places the phenomenon of "adult neurogenesis" into the contexts of stem cell biology and of developmental neurobiology
- Fosters a realistic view of the opportunities and problems related to the envisioned therapeutic use of stem cells in the adult brain
This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience - the intersection between the discoveries that the adult brain makes new neurons and that it contains stem cells. The book begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumours, and dementias. This readable, single-authored volume is a unique resource for graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research.
Reviews
- 'Since most neurons of the human brain last throughout the life span, the discovery that in selected regions of the mammalian brain neurons can be produced during adulthood has fascinated both scientists and the general public. Because of the interesting conceptual and potential medical significance, more than the usual number of irreproducible claims and irresponsible promises have been made. This impressive monograph by Gerd Kempermann, a scientist who has devoted his entire research career to this important subject, is a must for those who seek a balance between hype and reality. The text is written with a keen sense of history and attention to details. It should be read by both specialists and the educated public.' -Pasko Rakic, Yale University
Contents
- 1 Introduction
- 2 History
- 3 Neural Stem Cells
- 4 Neuronal Development
- 5 Neurogenesis in Adult Olfactory System
- 6 Adult Hippocampal Neurogenesis
- 7 Technical Notes
- 8 Neurogenic and Non-neurogenic Regions
- 9 Regulation
- 10 Function
- 11 Comparative Biology
- 12 Medicine
Kempermann
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- Places the phenomenon of "adult neurogenesis" into the contexts of stem cell biology and of developmental neurobiology
- Fosters a realistic view of the opportunities and problems related to the envisioned therapeutic use of stem cells in the adult brain
This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience - the intersection between the discoveries that the adult brain makes new neurons and that it contains stem cells. The book begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumours, and dementias. This readable, single-authored volume is a unique resource for graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research.
Reviews
- 'Since most neurons of the human brain last throughout the life span, the discovery that in selected regions of the mammalian brain neurons can be produced during adulthood has fascinated both scientists and the general public. Because of the interesting conceptual and potential medical significance, more than the usual number of irreproducible claims and irresponsible promises have been made. This impressive monograph by Gerd Kempermann, a scientist who has devoted his entire research career to this important subject, is a must for those who seek a balance between hype and reality. The text is written with a keen sense of history and attention to details. It should be read by both specialists and the educated public.' -Pasko Rakic, Yale University
Contents
- 1 Introduction
- 2 History
- 3 Neural Stem Cells
- 4 Neuronal Development
- 5 Neurogenesis in Adult Olfactory System
- 6 Adult Hippocampal Neurogenesis
- 7 Technical Notes
- 8 Neurogenic and Non-neurogenic Regions
- 9 Regulation
- 10 Function
- 11 Comparative Biology
- 12 Medicine
Zielgruppe
Students in neurobiology, developmental biology and medicine, from the undergraduate level onwards, newcomers to the field of neural stem cell biology and adult neurogenesis, interested lay readers with some knowledge of biology.
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
- Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
- Naturwissenschaften Biowissenschaften Molekularbiologie
- Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
- Naturwissenschaften Biowissenschaften Proteinforschung
- Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
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