Buch, Englisch, 204 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 408 g
Mechanisms, Applications, and Therapeutic Implications
Buch, Englisch, 204 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 408 g
ISBN: 978-0-8493-3025-4
Verlag: Taylor & Francis
In the post-genomic era we have, at our fingertips, an incredible array of genomic sequences from a multitude of complex organisms. There remains, however, the critical need to understand the precise roles individual genes play in complex biological milieu. Bringing together authoritative reviews by renowned international leaders, this book presents cutting-edge research on inhibitors of gene expression and nucleic acid-based drugs. With numerous charts, diagrams, and graphs, the book covers the subject from lab bench to cancer-related clinical trials, making it an up-to-date and critical resource. Coverage includes discussions of ribozyme subtypes, structure-function aspects, and therapeutic applications; DNAzymes, their various subtypes, kinetics and biochemistry, and applications in target validation. Lastly, the mechanisms and multiple therapeutic applications of double-stranded oligonucleotide decoys are described.
Zielgruppe
Professional
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Foreword. Therapeutic Application of Ribozymes for Cardiovascular Disease. Development of Ribozymes as Cancer Therapeutics. RNA Interference: A Technology Based on an Ancient Gene Silencing Pathway. RNA-Cleaving DNA Enzymes in Gene Silencing: Room for Improvement? Deoxyribozymes and Medical Innovation. Effect of Modifications on the Intracellular Activity of a DNA Enzyme. Potential Therapeutic Applications of DNA Enzymes and siRNAs Against Viral and Cellular Genes. Use of DNAzymes for Target Gene Validation. DNAzymes Targeting Immediate-Early Genes as Inhibitors of Angiogenesis and Restenosis. Decoy Oligodeoxynucleotides as Viable Pharmaceutical Drugs.
