Miller Dynamic Combinatorial Chemistry

In Drug Discovery, Bioorganic Chemistry, and Materials Science
1. Auflage 2010
ISBN: 978-0-470-55154-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 240 Seiten, E-Book

Effective techniques for applying Dynamic CombinatorialChemistry
In a relatively short period, Dynamic Combinatorial Chemistry(DCC) has grown from proof-of-concept experiments in a few isolatedlabs to a broad conceptual framework with applications to anexceptional range of problems in molecular recognition, leadcompound identification, catalyst design, nanotechnology, polymerscience, and others. Bringing together a group of respectedexperts, this overview explains how chemists can apply DCC andfragment-based library methods to lead generation for drugdiscovery and molecular recognition in bioorganic chemistry andmaterials science.
Chapters cover:
* Basic theory
* Approaches to binding in proteins and nucleic acids
* Molecular recognition
* Self-sorting
* Catalyst discovery
* Materials discovery
* Analytical chemistry challenges
A comprehensive, single-source reference about DCC methods andapplications including aspects of fragment-based drug discovery,this is a core reference that will spark the development of newsolutions and strategies for chemists building structure librariesand designing compounds and materials.

Autoren/Hrsg.

Miller, Benjamin L.

Inhaltsverzeichnis

Preface.
Contributors.
Chapter 1: Dynamic Combinatorial Chemistry: An Introduction(Benjamin L. Miller).
Chapter 2: Protein-Directed Dynamic Combinatorial Chemistry(Michael F. Greaney and Venugopal T. Bhat).
Chapter 3: Nucleic Acid-Targeted Dynamic Combinatorial Chemistry(Peter C. Gareiss and Benjamin L. Miller).
Chapter 4: Complex Self-Sorting Systems (Soumyadip Ghosh andLyle Isaacs).
Chapter 5: Chiral Selection in DCC (Jennifer J. Becker andMichel R. Gagné).
Chapter 6: Dynamic Combinatorial Resolution (Marcus Angelin,Rikard Larsson, Pornrapee Vongvilai, Morakot Sakulsombat, and OlofRamström).
Chapter 7: Dynamic Combinatorial Chemistry and MassSpectrometry: A Combined Strategy for High Performance LeadDiscovery (Sally-Ann Poulsen and Hoan Vu).
Chapter 8: Dynamic Combinatorial Methods in Materials Science(Takeshi Maeda, Hideyuki Otsuka, and Atsushi Takahara).
Index.

Über Autor(innen)

Benjamin L. Miller is an Associate Professor of Dermatology, Biomedical Engineering, and Biochemistry and Biophysics at the University of Rochester. In addition to his academic credentials, Dr. Miller has industry consulting experience as the founder of Adarza BioSystems and Lighthouse Biosciences.