Moinfar Essentials of Diagnostic Breast Pathology

A Practical Approach
1. Auflage 2007
ISBN: 978-3-540-45120-4
Verlag: Springer Berlin Heidelberg
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 496 Seiten

Autoren/Hrsg.

Moinfar, Farid

Inhaltsverzeichnis

1;Dedication;5
2;Preface;6
3;Contents;8
4;Abbreviations;11
5;The Normal Breast;12
5.1;Contents;12
5.2;CHAPTER 1 The Normal Breast;13
5.2.1;1.2 Pregnancy and Lactation;13
5.2.2;1.1 Anatomy;13
5.2.3;1.3 Menopause;14
5.2.4;1.4 Immunoprofile;14
5.2.5;1.5 Further Reading;14
6;Specimen Processing;17
6.1;Contents;17
6.2;CHAPTER 2 Specimen Processing;18
6.2.1;2.1 Frozen Section;18
6.2.2;2.2 Core Needle Biopsy;19
6.2.3;2.3 Excisional Biopsy Caution;20
6.2.4;2.4 Mastectomy;21
6.2.5;2.5 Axillary Lymph Nodes;21
6.2.6;2.6 Sentinel Lymph Nodes;22
6.2.7;2.7 Further Reading;22
7;Fibrocystic Change and Duct Ectasia ;24
7.1;Contents;24
7.2;CHAPTER 3 Fibrocystic Change and Duct Ectasia;25
7.2.1;3.1 Fibrocystic Change;25
7.2.2;3.2 Duct Ectasia (Periductal Mastitis);26
8;Adenosis;34
8.1;Contents;34
8.2;CHAPTER 4 Adenosis;35
8.2.1;4.1 Definition, Types, and Macroscopy of Adenosis;35
8.2.2;4.2 Blunt Duct Adenosis;35
8.2.3;4.3 Sclerosing Adenosis;36
8.2.4;4.4 Apocrine Adenosis ( Adenosis with Apocrine Metaplasia);37
8.2.5;4.5 Tubular Adenosis;38
8.2.6;4.6 Adenomyoepithelial Adenosis;38
8.2.7;4.7 Microglandular Adenosis;39
8.2.8;4.8 Radial Scar/Complex Sclerosing Lesion;39
8.2.9;4.9 Collagenous Spherulosis;41
9;Intraductal Proliferative Lesions ;73
9.1;Contents;73
9.2;CHAPTER 5 Intraductal Proliferative Lesions;74
9.2.1;5.1 Usual Ductal Hyperplasia;74
9.2.2;5.2 Ductal Intraepithelial Neoplasia (DIN);76
9.2.3;5.3 Ductal Intraepithelial Neoplasia (DIN), Flat Type;78
9.2.4;5.4 Low-Grade Ductal Intraepithelial Neoplasia ( WHO: DIN1b; Atypical Ductal Hyperplasia);80
9.2.5;5.5 Ductal Intraepithelial Neoplasia ( WHO: DIN1c– DIN3, DCIS);82
10;Intraductal Papillary Neoplasms;128
10.1;Contents;128
10.2;CHAPTER 6 Intraductal Papillary Neoplasms;129
10.2.1;6.1 Central Papilloma;129
10.2.2;6.2 Peripheral Papilloma;129
10.2.3;6.3 Sclerosing Papilloma;130
10.2.4;6.4 Intraductal Papillary Carcinoma ( Papillary Ductal Intraepithelial Neoplasia);130
10.2.5;6.5 Role of Immunohistochemistry in Diagnosing Intraductal Papillary Neoplasms;131
10.2.6;6.6 Additional Comments;131
10.2.7;6.7 Further Reading;132
11;Lobular Intraepithelial Neoplasia ( LIN);159
11.1;Contents;159
11.2;CHAPTER 7 Lobular Intraepithelial Neoplasia ( LIN);160
11.2.1;7.1 Synonyms;160
11.2.2;7.2 Background;160
11.2.3;7.3 Microscopic Features;160
11.2.4;7.4 Additional Comments;160
11.2.5;7.5 Further Reading;161
12;Infiltrating Ductal Carcinoma ( NOS Type) ;181
12.1;Contents;181
12.2;CHAPTER 8 Infiltrating Ductal Carcinoma ( NOS Type);182
12.2.1;8.1 Definition;182
12.2.2;8.2 Macroscopy;182
12.2.3;8.3 Microscopic Features;182
12.2.4;8.4 Grading;182
12.2.5;8.5 Additional Comments;183
12.2.6;8.6 Further Reading;183
13;Invasive Lobular Carcinoma ( ILC) ;191
13.1;Contents;191
13.2;CHAPTER 9 Invasive Lobular Carcinoma (ILC);192
13.2.1;9.1 Macroscopy;192
13.2.2;9.2 Microscopic Features;192
13.2.3;9.3 Additional Comments;192
13.2.4;9.4 Immunohistochemistry of LIN and ILC;192
13.2.5;9.5 Grading;192
13.2.6;9.6 Further Reading;193
14;Special Types of Breast Carcinomas;220
14.1;Contents;220
14.2;CHAPTER 10 Special Types of Breast Carcinomas;222
14.2.1;10.1 Tubular Carcinoma;222
14.2.2;10.2 Mucin-Producing Carcinomas of the Breast;223
14.2.3;10.3 Carcinoma with Neuroendocrine Differentiation;225
14.2.4;10.4 Invasive Papillary Carcinoma;226
14.2.5;10.5 Invasive Micropapillary Carcinoma;226
14.2.6;10.6 Apocrine Carcinoma;227
14.2.7;10.7 Secretory Carcinoma;228
14.2.8;10.8 Adenoid Cystic Carcinoma;229
14.2.9;10.9 Acinic Cell Carcinoma;230
14.2.10;10.10 Sebaceous Carcinoma;231
14.2.11;10.11 Infiltrating Cribriform Carcinoma;231
14.2.12;10.12 Medullary Carcinoma;232
14.2.13;10.13 Metaplastic Carcinomas;233
14.2.14;10.14 Clear Cell (Glycogen-Rich) Carcinoma;236
14.2.15;10.15 Lipid-Rich Carcinoma ( Lipid- Secreting Carcinoma);237
14.2.16;10.16 Metastatic Carcinoma;237
14.2.17;10.17 Inflammatory Carcinoma;238
15;Biphasic Tumors;316
15.1;Contents;316
15.2;CHAPTER 11 Biphasic Tumors;317
15.2.1;11.1 Fibroadenoma;317
15.2.2;11.2 Phylloides Tumor;318
16;Diseases of the Nipple;347
16.1;Contents;347
16.2;CHAPTER 12 Disease of the Nipple;348
16.2.1;12.1 Paget’s Disease;348
16.2.2;12.2 Nipple Duct Adenoma;349
16.2.3;12.3 (Infiltrating) Syringomatous Adenoma;350
17;Male Breast Lesions;360
17.1;Contents;360
17.2;CHAPTER 13 Male Breast Lesions;361
17.2.1;13.1 Gynecomastia;361
17.2.2;13.2 Papilloma;362
17.2.3;13.3 Primary Male Breast Carcinoma;362
17.2.4;13.4 Further Reading;362
18;Mesenchymal Lesions/ Tumors ;369
18.1;Contents;369
18.2;CHAPTER 14 Mesenchymal Lesions/Tumors;371
18.2.1;14.1 Stromal Elastosis ;371
18.2.2;14.2 Fat Necrosis;371
18.2.3;14.3 Metaplasias;372
18.2.4;14.4 Pseudoangiomatous Stromal Hyperplasia;372
18.2.5;14.5 Fibromatosis;373
18.2.6;14.6 Myofibroblastoma;374
18.2.7;14.7 Lipoma;375
18.2.8;14.8 Angiolipoma;375
18.2.9;14.9 Granular Cell Tumor;376
18.2.10;14.10 Hamartoma;377
18.2.11;14.11 Perilobular Hemangioma;377
18.2.12;14.12 Hemangioma;378
18.2.13;14.13 Angiomatosis;378
18.2.14;14.14 Angiosarcoma;379
18.2.15;14.15 Leiomyosarcoma;380
18.2.16;14.16 Liposarcoma;381
18.2.17;14.17 Rhabdomyosarcoma;381
18.2.18;14.18 Malignant Fibrous Histiocytoma;382
18.2.19;14.19 Osteosarcoma;383
18.2.20;14.20 Spindle Cell Sarcoma, Not Otherwise Specified ( NOS- Type Mammary Sarcoma);383
19;Myoepithelial Lesions/ Neoplasms ;401
19.1;Contents;401
19.2;CHAPTER 15 Myoepithelial Lesions/Neoplasms;402
19.2.1;15.1 Background;402
19.2.2;15.2 Immunoprofile;402
19.2.3;15.3 Myoepithelial Cell Hypertrophy;402
19.2.4;15.4 Myoepitheliosis (Myoepithelial Hyperplasia);402
19.2.5;15.5 Adenomyoepithelioma;403
19.2.6;15.6 Sarcomatoid Carcinoma with Myoepithelial Differentiation ( Myoepithelial Carcinoma, Malignant Myoepithelioma);404
20;Miscellaneous Lesions;410
20.1;Contents;410
20.2;CHAPTER 16 Miscellaneous Lesions;411
20.2.1;16.1 Acute Mastitis (Puerperal Mastitis);411
20.2.2;16.2 Subareolar Abscess;411
20.2.3;16.3 Plasma Cell Mastitis;411
20.2.4;16.4 Idiopathic Granulomatous Mastitis;412
20.2.5;16.5 Lymphocytic Mastitis (Diabetic Mastopathy);412
20.2.6;16.6 Eosinophilic Mastitis;413
20.2.7;16.7 Silicone Mastitis and Diseases Associated with Cosmetic Augmentation;413
20.2.8;16.8 Further Reading;413
20.2.9;16.9 Pathologic Effects of Adjuvant Radiotherapy;414
20.2.10;16.10 Pathologic Effects of ( Neo) adjuvant Chemotherapy;414
20.2.11;16.11 Malignant Lymphoma;415
20.2.12;16.12 Diffuse Large B-Cell Lymphoma;415
20.2.13;16.13 Burkitt’s Lymphoma;416
20.2.14;16.14 Extranodal Marginal-Zone B-Cell Lymphoma of MALT Type;416
20.2.15;16.15 Follicular Lymphoma;416
21;Cytopathology of Benign and Malignant Lesions ( Selected Topics) ;428
21.1;Contents;428
21.2;CHAPTER 17 Cytopathology of Benign and Malignant Lesions ( Selected Topics);429
21.2.1;17.1 Introduction;429
21.2.2;17.2 Fibrocystic Change;429
21.2.3;17.3 Proliferative Breast Diseases Without Atypia(Adenosis, Ductal Hyperplasia; Fig. 105);429
21.2.4;17.4 Proliferative Breast Lesions with Atypia;429
21.2.5;17.5 Lactating Adenoma and Lactating Changes;430
21.2.6;17.6 Fibroadenoma;430
21.2.7;17.7 Intraductal Papilloma;430
21.2.8;17.8 Ductal Intraepithelial Neoplasia(Ductal Carcinoma In Situ) ;430
21.2.9;17.9 Lobular Intraepithelial Neoplasia;431
21.2.10;17.10 Intraductal Papillary Carcinoma;431
21.2.11;17.11 Infiltrating Ductal Carcinoma;431
21.2.12;17.12 Infiltrating Lobular Carcinoma;431
21.2.13;17.13 Tubular Carcinoma;432
21.2.14;17.14 Mucinous Carcinoma;432
21.2.15;17.15 Medullary Carcinoma;432
21.2.16;17.16 Apocrine Carcinoma;432
21.2.17;17.17 Adenoid Cystic Carcinoma;432
21.2.18;17.18 Metaplastic (Sarcomatoid) Carcinoma;433
21.2.19;17.19 Phylloides (Phyllodes) Tumor;433
21.2.20;17.20 Further Reading;433
22;Immunohistochemistry ( Selected Topics) ;459
22.1;Contents;459
22.2;CHAPTER 18 Immunohistochemistry ( Selected Topics);460
22.2.1;18.1 Role of Immunohistochemistry in Diagnostic Breast Pathology;460
22.2.2;18.2 Immunohistochemistry in the Differential Diagnosis of Epithelial Lesions: Myoepithelial Cells;460
22.2.3;18.3 Carcinomas with Myoepithelial Differentiation Versus Primary Sarcoma;461
22.2.4;18.4 Microinvasive Carcinoma;461
22.2.5;18.5 Cell Population in Intraductal Proliferative Lesions: Homogeneous Versus Heterogeneous Cell Population ( Neoplasia Versus Hyperplasia);461
22.2.6;18.6 Paget’s Disease;462
22.2.7;18.7 Distinction Between DIN (DCIS) and LIN (LCIS);462
22.2.8;18.8 Systemic Metastasis of Breast Carcinoma;462
22.2.9;18.9 Micrometastatic Disease in Axillary Lymph Nodes ( Including Sentinel Nodes);462
22.2.10;18.10 Immunohistochemistry for Prognostic or Predictive Factors in Breast Carcinoma: Hormone Receptors;463
22.2.11;18.11 HER2/neu Overexpression;463
22.2.12;18.12 Further Reading;463
23;Subject Index;480