Molecular Responses to Xenobiotics

Erscheinungsjahr 2001
ISBN: 978-0-444-50640-5
Verlag: Elsevier Science & Technology

Buch, Englisch

Based upon the most advanced tools and concepts developed in modern biology, this work on molecular toxicity provides clear insight into the xenobiotic target(s), activity and mechanism of action, and reveals the detailed response and fate of the cell. It is therefore the most reliable assessment of toxic risks, particularly in the long term, prior to clinical trials. Compared to present-day toxicology procedures, molecular toxicology is reliable in assessing risks for humans, it is informative, fast and complies with all GLP standards. The articles contained in this volume were written by leading experts in the field and each article is introduced with a tutorial, for those not familiar with the concepts and described methods.

Fachgebiete

• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Biowissenschaften Toxikologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Exobiologie, Astrobiologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Astronomie Exobiologie, Astrobiologie, Xenobiologie

Inhaltsverzeichnis

Use of the nuclear receptor PXR to predict drug interactions (J.T. Moore, S.A. Kliewer).
A causal relationship between unscheduled eicosanoid signaling and tumor development: cancer chemoprevention by inhibitors of arachidonic acid metabolism (F. Marks, K. Müller-Decker, G. Fürstenberger).
NF-kB activation in response to toxical and therapeutical agents: role in inflammation and cancer treatment (V. Bours, G. Bonizzi, M. Bentires-Alj, F. Bureau, J. Piette, P. Lekeux, M.-P. Merville).
Advances in molecular toxicology - towards understanding idiosyncratic drug toxicity (B.K. Park, N.R. Kitteringham, H. Powell, M. Pirmohamed).
Applications and pitfalls of stress-proteins in biomonitoring (J.G.E.A. Bierkens).
Is CYP1A1 induction always related to AHR signaling pathway? (C. Delescluse, G. Lemaire, G. de Sousa, R. Rahmani).
Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology (J.M. Matés).
Ultrasensitive and specific detection methods for exocylic DNA adducts: Markers for lipid peroxidation and oxidative stress (H. Bartsch, J. Nair).
Conformational toxicity and sporadic conformational diseases (C. Reiss, T. Lesnik, H. Parvez, S. Parvez, R. Ehrlich). Apoptosis induced by an endogenous neurotoxin, 'N'-methyl('R')salsolinol, in dopamine neurons (M. Naoi, W. Maruyama, Y. Akao, J. Zhang, H. Parvez).
Nitric oxide and neuronal and pancreatic beta cell death (E. Adeghate, S.H. Parvez).
Cell death induced by MPTP, a substrate for monoamine oxidase B (A. Nicotra, S.H. Parvez).
Pathogenesis of vascular dementia in stroke-prone spontaneously hypertensive rats (S. Kimura, H. Saito, M. Minami, H. Togashi, N. Nakamura, M. Nemoto, H.S. Parvez).
The xenobiotic methionine sulfoximine modulates carbohydrate anabolism and related genes expression in rodent brain (K. Hélary-Bernard, M.-Y. Ardourel, J.F. Cloix, T. Hevor).
Neurochemistry and neuropharmacology of emesis - the role of serotonin (T. Endo, M. Minami, M. Hirafuji, T. Ogawa, K. Akita, M. Nemoto, H. Saito, M. Yoshioka, S.H. Parvez).
Expression and regulation of hepatic drug and bile acid transporters (V. Lecureur, A. Courtois, L. Payen, L. Verhnet, A. Guillouzo, O. Fardel).
Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology (C. Lerche-Langrand, H.J. Toutain).
Cytotoxicity assessment of chlorinated bacteria in water using the RNA synthesis inhibition method (K.A. Ferey, C. Fauris, G.P. Husson, R. Vilagines).