Handbook of H+-ATPases

1. Auflage 2014
ISBN: 978-981-4411-91-2
Verlag: Pan Stanford

Buch, Englisch, 504 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 816 g

This handbook on vacuolar and plasma membrane H+-ATPases is the first to focus on an essential link between vacuolar H+-ATPase and the glycolysis metabolic pathway to understand the mechanism of diabetes and the metabolism of cancer cells. It presents recent findings on the structure and function of vacuolar H+-ATPase in glucose promoting assembly and signaling, in addition to describing the regulatory mechanisms of vacuolar H+-ATPase in yeast cells, neural stem cells, kidney cells, cancer cells, as well as under diabetic conditions.

Zielgruppe

Academic and Postgraduate

Autoren/Hrsg.

Nakamura, Suguru

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Nephrologie

Inhaltsverzeichnis

Vacuolar H+-ATPase Assembly. Structure of Prokaryotic V type ATPase/synthase. The function of V-ATPase in the degradation of gluconeogenic enzymes in the yeast vacuole. The Role of Vacuolar ATPase in the Regulation of Npt2a Trafficking. Cytosolic pH regulated by glucose promotes V-ATPase assembly. Vacuolar H+-ATPase (V-ATPase) activated by glucose, a possible link to diabetic disease. Vacuolar proton pump (V-ATPase) and insulin secretion. Role of V-ATPase, cytohesin-2/Arf6 and aldolase in regulation of endocytosis: Implications for diabetic nephropathy. Renal Vacuolar H+-ATPase Regulation. Long-term Regulation of Vacuolar H+-ATPase by Angiotensin II in Proximal Tubule Cells. Vacuolar H+-ATPase in Distal Renal Tubular Acidosis and Diabetes. Vacuolar H+-ATPase in Cancer and Diabetes. The a2 isoform of Vacuolar ATPase and Cancer-Related Inflammation. V-ATPases in oral squamous cell carcinoma. Vacuolar H(+)-ATPase: functional mechanism and potential as a target for cancer chemotherapy. Vacuolar H+-ATPase Maintains Neural Stem Cells in the Developing Mouse Cortex. The relationship between glucose-induced calcium signaling and activation of the plasma membrane H+-ATPase in Saccharomyces cerevisiae cells.

Über Autor(innen)

Dr. Nakamura received his M.D. degree from the Jiangxi Medical University in 1984 and his Ph.D. from the Tokyo Medical and Dental University in 1995. Dr. Nakamura joined Murray State University in 2003 and his current position is Associate Professor of Biological Sciences. His research is focused on the physiological studies of acid-base balance and ion transports in the kidney.