Buch, Englisch, 725 Seiten, Format (B × H): 225 mm x 285 mm, Gewicht: 1963 g
Buch, Englisch, 725 Seiten, Format (B × H): 225 mm x 285 mm, Gewicht: 1963 g
ISBN: 978-1-55581-453-3
Verlag: ASM PR
Enables students and professionals to develop a deep understanding of fundamental virology by emphasizing principles and discussing virusesorganized by virus family.
Examines individual virus families within the context of the Baltimore classification system, a key unifying theme that allows readers to assume basic facts about the replication strategy of a virus based on the nature of its genome.
Explores the various modes of virus infection and disease, and considers host defenses against microorganisms and viral countermeasures to subvert those host defenses.
Details the organization of the viral genome and its pattern of expression, with additional discussions covering viral structure, entry, assembly, release, and associated medical issues.
This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.
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Table of Contents
Part I. Introduction
1. A Selective History on the Nature of Viruses
Introduction
The Early Years: Discoverers and Pioneers
The First Stirrings of the Molecular Era
The Phage Group
Phage Growth: Eclipse and Replication
Defining Viruses
Are Viruses Alive?
Origin of Viruses
The Modern Era of Animal Virology
2. Biosynthesis of Viruses: An Introduction to Virus Classification
T-Even Bacteriophages as a Model System
T-Even Phage Structure and Entry
Sequence of Phage Biosynthetic Events
Phage Protein Synthesis
RNA Metabolism in Infected Cells
Assembly of Progeny Phages
Packaging DNA within the Phage Particle
Unique Features of T-Even Phages
Modified Bases
Regulated Gene Expression
Phage Release: Lysozyme and the rII Region
Bacteriophage Lambda: Lysogeny and Transduction
Some Final Comments on Bacteriophages
Introduction to the Animal Viruses
Animal Virus Structure
Entry of Animal Viruses
The Families of Animal Viruses: Principles of Classification
Viral Genetic Systems: The Baltimore Classification Scheme
3. Modes of Virus Infection and Disease
Introduction
Portals of Entry
Routes of Dissemination
Hematogenous and Neural Dissemination
The Placenta and the Fetus
Acute versus Persistent Infections
Acute Infections
Persistent Infections
Slow Infections
Chronic Infections
Latent Infections
Transmissible Spongiform Encephalopathies: Prions
4. Host Defenses and Viral Countermeasures
Introduction
Overview of Defenses
Physical Barriers against Infection
The Innate Immune System
Cytokines: the Interferons
Cytokines: TNF-[alpha], Some Other Cytokines, and Inflammation
Macrophages, Neutrophils, and NK Cells and ADCC
The Complement System
Viral Evasion of Innate Immunity
Evasion of Interferons
Evasion of Cytokines
Evasion of NK Cells and ADCC
Evasion of Complement
APOBEC3G and the HIV Vif Protein
The Adaptive Immune System
Antibodies and B Cells
Antibody Diversity
Viral Evasion of Antibodies
Cell-Mediated Immunity
Antigen Presentation by MHC Class I Molecules
Antigen Presentation by MHC Class II Molecules
The Rationale for MHC Restriction
Activation of Helper T Cells: Dendritic Cells and B Cells
Activation of B Cells
Activation of CTLs
Mechanism of Action of CTLs
T Cells and Antiviral Cytokines
Viral Evasion of Cell-Mediated Immunity
Inhibition of Antigen Presentation to CTLs
Inhibition of Antigen Presentation to Helper T Cells
Inhibition of Apoptosis
Immunological Memory
Self Tolerance
The Immune System in Disease
Immunopathology
Autoimmune Disease
Part II. Virus Replication and Pathogenesis
subpart RNA Viruses: Double-Stranded
5. Reoviruses
Introduction
Structure, Binding, Entry, and Uncoating
Reovirus Binding and Entry into the Cell
Structure, Uncoating, and Entry into the Cytoplasm
The Reovirus Genome: Transcription and Translation
The Particle-Associated RNA Polymerase
The Segmented Reovirus Genome
Conversion of ISVPs to Cores
Replication and Encapsidation of the Reovirus Genome
Synthesis of Double-Stranded RNA
Assembly of Progeny Subviral Particles; Encapsidation of RNA Segments
Reoviruses and Interferon
Primary versus Secondary Transcription
Final Virus Assembly
Pathogenesis
Orthoreoviruses
Rotaviruses
Coltiviruses
subpart RNA Viruses: Single-Stranded
6. Picornaviruses
Introduction
Structure, Binding, and Entry
Picornavirus Structure
Rhinovirus Receptor and Binding: the Canyon Hypothesis
The Poliovirus Receptor
Receptors for Coxsackieviruses and Other Enteroviruses
Receptors for Foot and Mouth Disease Viruses
Poliovirus and Rhinovirus Entry: Some General Points
Poliovirus Entry
Human Rhinovirus Entry
Poliovirus and Rhinovirus Entry: Why the Differences?
Translation
Translation: Part I
Translation: a Digression
The RNA Phages
Picornaviruses versus RNA Phages: Why the Differences?
Translation: Part II
Transcription and Genome Replication
Assembly and Maturation
Medical Aspects
Poliovirus
Rhinoviruses: the Common Cold
Coxsackievirus and Echovirus
Viral Hepatitis: Hepatitis A Virus
7. Flaviviruses
Introduction
Structure and Entry
Replication
Assembly and Release
Historic Interlude: Identification of Hepatitis C Virus
West Nile Virus: an Emerging Virus
Epidemiology and Pathogenesis
General Principles of Arthropod Transmission
Infection, Dissemination, and Determinants of Pathogenesis
Hemorrhagic Fever Viruses: Yellow Fever and Dengue
Encephalitis Viruses: Japanese Encephalitis, St. Louis Encephalitis, and West Nile Viruses
Japanese Encephalitis and St. Louis Encephalitis Viruses
West Nile Virus
Hepatitis C Virus
8. Togaviruses
Introduction
Structure and Entry
Transcription, Translation, and Genome Replication
Assembly and Maturation
Epidemiology and Pathogenesis
Alphaviruses That Cause Encephalitis: Eastern, Western, and Venezuelan Equine Encephalitis Viruses
Alphaviruses That Cause Arthritis: Chikungunya, Ross River, and Sindbis Viruses
Rubella Virus
9. Coronaviruses
Introduction
Structure
Entry
Genome Organization and Expression
Coronavirus mRNAs and Their Translation
Coronavirus Transcription
Coronavirus Recombination
Coronavirus Reverse Genetics
Assembly and Release
Medical Aspects
SARS
10. Rhabdoviruses
Introduction
Structure
Entry
Genome Organization, Expression, and Replication
The General Transcriptional Strategy of Viruses That Contain Negative-Sense RNA Genomes
Gene Organization and Transcription
Replication
Assembly and Release
Medical Aspects
Cytopathic Effects
Vesicular Stomatitis Virus
Rabies Virus
11. Paramyxoviruses
Introduction
Structure
Entry
Syncytium Formation
Genome Organization, Expression, and Replication
Genome Organization and Transcription
Replication
Assembly and Release
Medical Aspects
Measles
Clinical Conditions
Sclerosing Panencephalitis (SSPE)
Where Did It Come From?
