Osada Bioprobes

Biochemical Tools for Investigating Cell Function
2000
ISBN: 978-4-431-65927-3
Verlag: Springer Tokyo
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 319 Seiten, eBook

Rapid advances in the study of the molecular basis of mammalian cell proliferation, differentiation, and apoptosis have made it possible to develop new screening systems for isolating from microbial metabolites specific inhibitors of mammalian cell functions. "Bioprobes" is the term used to describe these inhibitors, which are extremely useful agents in investigating the molecular and chemical regulation of eukaryotic cell function and apoptosis. Another area where bioprobes are playing an important role is research into immune cell function. This book is the first to present the groundbreaking applications of bioprobes as tools for biochemical research. A large appendix contains the chemical structure, origin, function, key references, and other essential data for more than 80 important bioprobes. The information for each bioprobe is shown in a two-page display, in an easy-to-use format for identifying specific bioprobes for investigation of cell function.

Zielgruppe

Research

Autoren/Hrsg.

Osada, H.

Inhaltsverzeichnis

1 Trends in Bioprobe Research.- 1 Introduction.- 2 Sources of Bioprobes.- 3 Development of Bioprobes.- 4 Targets for Bioprobes.- 5 Trends and Prospects.- References.- 2 Cell Proliferation: From Signal Transduction to Cell Cycle.- 1 Introduction.- 2 Membrane/Cytoplasmic Signal Transduction.- 3 Nuclear Signal Transduction.- 4 Cell Cycle Control.- 5 Future Prospects.- References.- 3 Differentiation.- 1 Introduction.- 2 Differentiation of Hematopoietic Cells.- 3 Differentiation of Neuron Cells.- 4 Differentiation of Skeletal Cells (Bone and Muscle Cells).- 5 Differentiation of Liver: Hepatocytes.- 6 Epidermal Differentiation.- References.- 4 Apoptosis.- 1 Introduction.- 2 Tyrosine Kinase.- 3 Ceramide Synthesis.- 4 Fas Signaling.- 5 c-Jun NH2-Terminal Kinase.- 6 Cyclooxygenase-2.- 7 Calmodulin-Dependent Kinase III.- 8 PI-3 Kinase-Akt.- 9 Cell Cycle Regulator.- 10 p53.- 11 Hydroxymethyl Glutaryl CoA Reductase.- References.- 5 Immune Cell Functions.- 1 Introduction: Immune Network.- 2 Bioprobes for Lymphocyte Proliferation.- 3 Signal Transduction and Gene Expression in the Process of T Cell Activation.- 4 Cell-Mediated Cytotoxicity and Its Bioprobes.- 5 Conclusions.- References.- 6 Bioprobes at a Glance.- Authors and Collaborators.