Human and Mosquito Lysozymes

Old Molecules for New Approaches Against Malaria
2015
ISBN: 978-3-319-09431-1
Verlag: Springer International Publishing

Buch, Englisch, 108 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 354 g

Malaria remains an alarming emergency in developing countries. It is thus urgent to identify any parasite or host molecules that can serve as new affordable markers for early diagnosis of disease complications or as new targets for vector control. In this context, human and mosquito lysozymes are good candidate molecules, as their involvement in malaria has been recently reported by several independent groups. This book reviews the grounded knowledge on malaria etiology and physiopathology, as well as the current approaches for diagnosis, therapy, and vector control. In addition, the emerging evidence on the involvement of human and mosquito lysozymes in malaria from available experimental models and clinical studies is thoroughly discussed, as is the potential use of other antimicrobial peptides against malaria. Intriguingly, the contributors propose that old well-known molecules such as lysozymes might be used as new targets for cost-effective strategies to fight malaria.

Zielgruppe

Research

Autoren/Hrsg.

Prato, Mauro

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Parasitologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Umweltmedizin, Arbeitsmedizin, Tropenmedizin, Sportmedizin Reisemedizin, Tropenmedizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Infektionskrankheiten

Inhaltsverzeichnis

Etiopathogenesis and pathophysiology of malaria.- Malaria diagnosis, therapy, vaccines and vector control.- Lysozymes in the animal kingdom.- Role of lysozymes of Anopheles mosquitoes in Plasmodium development.- Effects of malaria products on human monocyte and neutrophil degranulation and lysozyme release.- Human lysozyme in malaria patients.- Beyond lysozyme.

Über Autor(innen)

Mauro Prato currently works as an Adjunct Professor of Biochemistry at the University of Torino, Italy. His research activity focuses on the involvement of proteolytic enzymes in malaria. His track-record includes 40 papers published by peer-reviewed journals, 1 book, 7 book chapters, 97 communications in well-established conferences, and 1 patent.