Rokita Quinone Methides

1. Auflage 2009
ISBN: 978-0-470-45287-5
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 456 Seiten, E-Book

Reihe: Wiley Series of Reactive Intermediates

Multidisciplinary perspectives and approaches to quinonemethides research
The Wiley Series on Reactive Intermediates in Chemistry andBiology investigates reactive intermediates from the broadestpossible range of disciplines. The contributions in each volumeoffer readers fresh insights into the latest findings, emergingapplications, and ongoing research in the field from a diverseperspective.
This inaugural volume in the series, Quinone Methides,represents the first book devoted to this fascinating and usefulintermediate. The authors of this work reflect the many disciplinesand approaches to quinone methides research. The volume thereforecovers a broad range of topics, including theoretical treatments,generation and detection of intermediates, characterization andapplications in chemistry and biochemistry, and biologicalreactivity. Among the chapters are:
* Photochemical generation and characterization of quinonemethides
* Quinone methide stabilization by metal complexation
* Self-immolative dendrimers based on quinone methides
* Characterization of quinone methides by spectral global fittingand 13C labeling
* Formation and reactions of xenobiotic quinone methides inbiology
* Quinone methides in lignification
With this collection of topics, readers already familiar withquinone methides have the opportunity to advance their own researchby discovering new inspiration and opportunities in allied areas.Moreover, the range of topics and perspectives covered make thisvolume accessible to readers with a broad range of interests,including organic and physical chemistry, biochemistry,biotechnology, and pharmaceutics.

Autoren/Hrsg.

Rokita, S. E.

Inhaltsverzeichnis

Chapter 1: Photochemical Generation and Characterization ofQuinone-Methides (Matthew Lukeman).
Chapter 2: Modeling Properties and Reactivity of QuinoneMethides by DFT calculations (Mauro Freccero and FilippoDoria).
Chapter 3: Quinone Methide Stabilization by Metal Complexation(David Milstein and Elena Poverenov).
Chapter 4: Intermolecular Applications of o-Quinone Methides(o-QMs) Anionically Generated at Low Temperatures; KineticConditions (Thomas Pettus and Liping Pettus).
Chapter 5: Self-Immolative Dendrimers Based on Quinone Methides(Doron Shabat and Rotem Erez).
Chapter 6: Ortho-Quinone Methides in Tocopherol Chemistry(Thomas Rosenau and Stefan Böhmdorfer).
Chapter 7: Characterizing Quinone Methides by Spectral GlobalFitting and 13C Labeling (Edward B. Skibo).
Chapter 8: Natural Diterpene and Triterpene Quinone Methides:Structures, Synthesis and Biological Potentials (Qibing Zhou).
Chapter 9: Reversible Alkylation of DNA by Quinone Methides(Steven E. Rokita).
Chapter 10: Formation and Reactions of Xenobiotic QuinoneMethides in Biology (Judy L. Bolton and John A. Thompson).
Chapter 11: Quinone Methides and Aza-Quinone Methides as LatentAlkylating Species in the Design of Mechanism-Based Inhibitors ofSerine Proteases and ß-Lactamases (Michèle Reboud-Ravauxand Michel Wakselman).
Chapter 12: Quinone Methides in Lignification (John Ralph, PaulF. Schatz, Fachuang Lu,Hoon Kim, Takuya Akiyama, and Stephen F.Nelsen).

Über Autor(innen)

STEVEN E. ROKITA, PhD, is Professor in the Department of Chemistry and Biochemistry at the University of Maryland. His research interests lie in sequence and conformation specific reactions of nucleic acids, enzyme-mediated activation of substrates and coenzymes, halogenation and dehalogenation reactions in biology, aromatic substitution and quinone methide generation in bioorganic chemistry, copper- and nickel-mediated reactions in bioinorganic chemistry, and electron transfer in biopolymers. Dr. Rokita has more than eighty publications and twelve patents on file to his credit.