Proinflammatory and Antiinflammatory Peptides

1. Auflage 1998
ISBN: 978-0-8247-0120-8
Verlag: CRC Press

Buch, Englisch, 756 Seiten, Format (B × H): 160 mm x 235 mm, Gewicht: 1129 g

Reihe: Lung Biology in Health and Disease

"Analyzes the role of peptides in promoting or suppressing inflammation. Thoroughly examines the therapeutic potential of key peptides, analogs, agonists, and antagonists that influence cell injury and repair."

Zielgruppe

Professional and Professional Reference

Autoren/Hrsg.

Said, Sami I

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Pneumologie, Atmung, Asthma

Inhaltsverzeichnis

Part 1 Cell injury and inflammation: inflammation, cell injury and apoptosis; proinflammatory and antiinflammatory response cytokines in the inflammatory response. Part 1 Proinflammatory peptides: proinflammatory peptides in sensory nerves of the airways; sensory neuropeptides and bronchial hyperresponsiveness; the tachykinin family of peptides and their receptors; endothelins in inflammation; endothelins in the lung; proinflammatory peptides in relation to other inflammatory mediators; cellular regulation of kinin receptors - potential roles in inflammation. Part 3 Antiinflammatory peptides: modulation of inflammatory effects of cytokines by the neuropeptide -MSH; regulation of VIP gene expression; neuroregulation of pulmonary immune responses by VIP and substance P; role of vasoactive intestinal peptide in myocardial ischaemia - reperfusion injury; antiinflammatory actions of VIP in the lungs and airways; VIP regulation of neuronal proliferation and differentiation; implications for neuronal repair; neurotrophic action of VIP - from CNS ontogeny to therapeutic strategy. Part 4 Modulation of peptide action - therapeutic applications: long-acting VIP analogs; catalytic anti-VIP antibodies and their relevance to the airways; enzymatic degradation of bradykinin; enzymatic modulation of the tachykinins and VIP in the lung; therapeutic effects and immunomodulatory activities of natriuretic peptides.

Über Autor(innen)

Sami I. Said