Organotypic Models in Drug Development

1. Auflage 2021
ISBN: 978-3-030-70062-1
Verlag: Springer International Publishing

Buch, Englisch, Band 265, 323 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 725 g

Reihe: Handbook of Experimental Pharmacology

This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.

Zielgruppe

Research

Autoren/Hrsg.

Schäfer-Korting, Monika

Landsiedel, Robert

Stuchi Maria-Engler, Silvya

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Gentherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie

Inhaltsverzeichnis

Inflammatory skin disease models in vitro and in animals – predictability for drug development.- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System.- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development.- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh.- Disease Models: Lung models for testing drugs against inflammation and infection.- In Vitro Models of the Blood-Brain Barrier.- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development.- The CAM Assay as an Alternative In Vivo Model for Drug Testing.- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development.- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling.- Immunocompetent human intestinal models in preclinical drug development.- EngineeredHeart Muscle Models in Phenotypic Drug Screens.