Stimuli-Responsive Drug Delivery Systems

Erscheinungsjahr 2018
ISBN: 978-1-78801-113-6
Verlag: RSC Publishing

Buch, Englisch, Band 1, 376 Seiten, Format (B × H): 163 mm x 234 mm, Gewicht: 680 g

Reihe: Biomaterials Science Series

The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials.

Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.

Autoren/Hrsg.

Singh, Amit

Amiji, Mansoor M

Weitere Mitwirkende

Vadgama, Pankaj

Narayan, Roger

Torchilin, Vladimir

Rawal, Meghana

Gao, Jinming

Sarmento, Bruce

Jhurry, Dhanjay

Vallet-Regi, María

Zhang, Ke

Pillay, Viness

Andrews, Jennifer

Garg, Sanjay

Kim, Jeong-Hwan

Lam, Kit

Govindaraju, T

Singh, Amit

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Naturwissenschaften Chemie Organische Chemie Polymerchemie

Inhaltsverzeichnis

Fundamentals of Stimuliresponsive Drug and Gene Delivery Systems; Materials and Chemistry of Stimuli-responsive Drug Delivery Systems; pH-responsive Drug Delivery Systems; Thermo-responsive Nanomedicines for Drug Delivery in the Gastrointestinal Tract; Redox-responsive Drug Delivery Systems; Magnetically-responsive DDS; Light-responsive Drug Delivery Systems; Integrated Polymer Composites for Electro-responsive Drug Delivery; Enzyme-responsive Drug Delivery Systems; Swelling-controlled Drug Delivery Systems; Biologically-inspired Stimuli-responsive DDS; Stimuli-responsive Materials in Theranostics; Stimuli-responsive Material Inspired Drug Delivery Systems and Devices; Regulatory and Commercialization Challenges with Stimuli-responsive Nanomedicines

Über Autor(innen)

Vadgama, Pankaj
Professor Pankaj Vadgama's particular interest is biosensors, where he has developed permselective, biocompatible, and biomimetic polymeric membranes capable of stable transduction in whole blood and tissue. Both in vivo and in vitro work has been undertaken, including the use of miniaturized devices for glucose and lactate monitoring, immunosensing, and interrogation of tissue-material interactions. Current research work includes interfacial problems relating to sensor/biomaterial contact with the biomatrix, and the generalizable insights that may emerge from this. Projects include: spider silk for tissue engineering, materials for implantable electronic devices, microfluidic based separation, cell-surface interactions, biomaterial degradation dynamics, conducting polymers as biomaterials, tissue bioreactor design, and cochlear implant electrodes.

Vallet-Regi, María
María Vallet-Regí was born in Las Palmas, Spain, in 1946. She studied Chemistry at the Universidad Complutense de Madrid (UCM) and received her PhD at the same University in 1974. She is full professor of Inorganic Chemistry and Head of the Department of Inorganic Chemistry and Bioinorganic at the Faculty of Pharmacy (UCM). Her current research field is solid state chemistry, covering aspects of synthesis, characterisation and reactivity in oxides and bioceramics.