Mitochondria-Targeted Drug Delivery Strategies for Cancer Therapy

Erscheinungsjahr 2026
ISBN: 978-0-443-40479-5
Verlag: Elsevier Science

Buch, Englisch, 420 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 449 g

Mitochondria-targeted Drug Delivery Strategies for Cancer Therapy explores the innovative use of biocompatible, multifunctional nanoplatforms to target mitochondria for selective drug delivery, enhancing treatment efficacy while minimizing side effects. This book provides a comprehensive overview of the role of nanotechnology in cancer treatment, reviewing the basics of nanotechnology and cancer biology, advanced nanoengineering strategies, and the development of mitochondria-targeted drug delivery systems, such as liposomal therapies, photosensitizer nanoparticles, and peptides for cancer treatment, along with strategies to modulate mitochondrial functions using nanomaterials. This book is a valuable resource to researchers and scientists interested in the application of nanotechnology for improved cancer therapy as it provides a thorough overview of real-world applications and future research trends, as well as a discussion on overcoming challenges in mitochondrial targeting.

Autoren/Hrsg.

Singh, Arun Kumar

Mishra, Neeraj

Pareek, Ashutosh

Kumar, Anoop

Sethi, Gautam

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie

Inhaltsverzeichnis

1. Introduction of nanotechnology: basic concept and properties
2. Basics of cancer biology, and role of nanotechnology in cancer treatment
3. Nanoparticle-Mediated Drug Delivery in Cancer Therapy: Addressing Drug Resistance Challenges
4. Advancing Targeted Drug Delivery in Malignancy: Nanoengineering Strategies for Enhanced Efficacy
5. Mitochondria in Cancer: Functions, Dysfunction, and Therapeutic Targets
6. Introduction to mitochondria-targeted Drug Delivery in cancer
7. Mitochondria-Targeted Drug Delivery Strategies for Cancer Treatment
8. Mitochondria-Targeted Liposomes in Cancer Therapy
9. Mitochondrial-Targeted Photosensitizers Nanoparticles in Photodynamic Therapy
10. Role of Mitochondria-Penetrating Peptides in Cancer Therapeutics
11. Modulating Mitochondrial Reactive Oxygen Species in Cancer Therapy through Nanomaterials
12. Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy
13. Characterization of Mitochondria-Targeted, Nanoparticle-Based Drug-Delivery System
14. Nanoplatforms: Overcoming Challenges in Mitochondrial Targeting for Effective Cancer Treatment
15. Future directions and emerging trends of Mitochondria-Targeted Drug Delivery Strategies: Challenges and future prospects
16. Clinical trials, toxicity studies and real-world applications of mitochondria-targeted drug delivery strategies

Über Autor(innen)

Sethi, Gautam
Dr. Gautam Sethi is a tenured Associate Professor in Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore. The focus of his research over the past few years has been to elucidate the mechanism(s) of activation of oncogenic transcription factors by carcinogens and inflammatory agents and the identification of novel inhibitors of these proteins for prevention of and therapy for cancer. The findings of his research work have so far resulted several publications in high impact factor peer reviewed journals and many international awards. He also serves as an editorial board member for over more than 15 international journals

Kumar, Anoop
Dr. Anoop Kumar is an Assistant Professor in the Department of Pharmacology at Delhi Pharmaceutical Sciences & Research University (DPSRU), India. With a distinguished career, he has previously served as an Assistant Professor and Head at the National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, and as Head and Associate Professor at ISF College of Pharmacy, Moga, Punjab. Dr. Kumar has also held research positions at Sun Pharmaceutical Industries Limited and Translational Health Science Institute (THSTI). He earned his Ph.D. from Birla Institute of Technology, Mesra, Ranchi, as a DST INSPIRE Fellow. He is an Associate Editor for Health Sciences Review and Acta Neurologica Scandinavica. His research focuses on drug repurposing, clinical trial meta-analysis, pharmacoeconomics, and pharmacovigilance.

Singh, Arun Kumar
Arun Kumar Singh has completed M. Pharm (Pharmaceutics) from Galgotias University, Greater Noida, India. Mr. Singh joined as an assistant professor in the Department of Pharmacy, Vivekanand Global University Jaipur Rajasthan 303012. His area of interest is in the area of Nano-formulation, Blockchain, IoT, Machine learning, Cancer, Artificial intelligence, Big data, and Neuroscience. He has authored one book with IOP publishing. He has published 5 chapters in big data with the prestigious River Publisher, in Denmark. He has also published 20 review papers among which two are in Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. He has published 26 books with different publishers like IOP, Elsevier, CRC PRESS, and Wiley. His strengths are research skills, innovation, leadership, decision-making, and positive thinking. His hard-working nature and devotion to their work make him distinguishable and extraordinary.

Pareek, Ashutosh
Dr. Ashutosh Pareek, Associate Professor at Banasthali Vidyapith with over 15 years of experience in pharmaceutical sciences, holds gold medals for his Master's and Bachelor's degrees in Pharmacy. Dr. Pareek specializes in neuropharmacology and innovative drug delivery systems, focusing on neurodegenerative disorders, cancer, and autoimmune diseases. His research includes developing advanced drug delivery systems for immunomodulators like naringenin. Dr. Pareek leads a research team working on these critical health issues and has published over 45 research papers and authored five technical books. He holds an international formulation patent and has received numerous awards, including the Zee National Achievers Award 2023. His work is funded by national and international agencies such as ICMR, DST-SERB, DBT, the American Association of Pharmaceutical Scientists, and the International Brain Research Organization. He serves as a Review Editor for Frontiers in Pharmacology and Frontiers in Oncology and reviews for leading journals by Elsevier, Springer, and Bentham.