The New Biology of Proteins
Buch, Englisch, 190 Seiten, Format (B × H): 178 mm x 237 mm, Gewicht: 426 g
ISBN: 978-0-8493-1442-1
Verlag: CRC Press
Prions: The New Biology of Proteins provides a well-organized overview of what is known about prion-related diseases. This comprehensive work reviews the symptoms, epidemiology, and neuropathology of the disease. It focuses on evidence supporting the idea that TSEs result from a novel disease mechanism: transmission by replication of the misfolding of a single protein in the absence of nucleic acids. Following this hypothesis, the book examines the structure, conversion, and mechanism of prion propagation and details its cellular biology. It explores the transmission, discusses the challenges involved with diagnosis, and considers various therapeutic avenues that are presently being explored.
A cohesive volume that integrates the pioneering work of many researchers, this book is authored by Claudio Soto, an internationally renowned researcher whose innovative work has led to an increased understanding of the heretical biology of prions and the development of novel strategies for treating and diagnosing neurodegenerative diseases.
As protein misfolding diseases are his specialty, Soto also looks at the phenomenon from a wider perspective. He examines other diseases that display folding aberrations, considers how commonly such aberrations occur in nature, and asks readers to open their minds to consider the impact of prions on broader areas of biology, public health, and biotechnological
Zielgruppe
Professional Reference
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Innere Medizin
- Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Industrielle Biotechnologie
- Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tierpathologie
Weitere Infos & Material
Prologue. Prion Diseases: Clinical Symptoms, Epidemiology and Neuropathology. The Infectious Agent and the Prion Hypothesis. The Prion Protein: Cell Biology, Genetic and Putative Function. Prion Replication by Transmission of Protein Conformation. Prion Strains and Multiple Conformations of the Prion Protein. Prions: From the Mouth to the Brain. Neurodegeneration in Prion Disease. The Diagnosis Problem and Current Tests. Therapeutic Approaches. Cyclic Amplification of Prion Protein: Rationale, Application and Perspectives. Other Diseases of Protein Misfolding. Prions: A Common Phenomenon in Biology?