Radiotheranostics: A Primer for Medical Physicists II

Radiochemistry, Radiobiology, Dosimetry, Safety, Economics, and AI
1. Auflage 2025
ISBN: 978-1-032-65970-1
Verlag: Taylor & Francis Ltd

Buch, Englisch, 264 Seiten, Format (B × H): 178 mm x 254 mm, Gewicht: 453 g

Reihe: Series in Medical Physics and Biomedical Engineering

The book will cover all the relevant theranostics aspects involving pairs of radiopharmaceuticals used in imaging and therapy for cancer treatment: historical
perspective; cancer biology and radiation biology models; clinical applications; radionuclide production and radiopharmaceutical preparation; source calibration and imaging instrumentation; biokinetic modelling and dosimetric formalisms; epidemiological studies and clinical trials; radiation safety considerations; regulatory requirements; staff education, training and competences; economic projections, and future outlook. It is planned to keep the chapters at a medium academic level. At this time, radiotheranostics information is dispersed in books, journals, congress proceedings and organizations’ websites. Compiling and organizing the material should give medical and health physicists not just the necessary tools to estimate and document the individual dosimetry of patients undergoing radiotheranostics treatment, but will also empower them to
• convince the cancer community that such a dosimetry improves cancer control and results
in longer survival times and
• influence national policy makers to require organ dose estimates/calculations.

The book is aimed at academic and practicing clinical medical and health physicists with
basic knowledge of nuclear medicine. Although the book is not meant as a textbook, medical
physicists in nuclear medicine physics training may also find the book useful.

Zielgruppe

Postgraduate, Professional Reference, and Professional Training

Autoren/Hrsg.

Borras, Cari

Borrás, Cari

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Nuklearmedizin, PET, Radiotherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Medizinische Diagnose und Diagnostik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pflege Fachpflege
• Naturwissenschaften Physik Angewandte Physik Medizinische Physik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung

Inhaltsverzeichnis

List of Common Acronyms

Part 1 – Introduction

Chapter 1. Radiotheranostics: Challenges Today

Part 2 – Radiochemistry and Radiobiology

Chapter 2. Radiopharmaceutical Preparations and Radiolabeling Strategies

Chapter 3. New Insights Into the Radiation Biology of Radiotheranostics

Chapter 4. Radiation Embryology: Human and Animal Studies

Part 3 – Particle Dosimetry

Chapter 5. Alpha- and Beta-particle Therapy and Dosimetry

Chapter 6. Auger Emitters

Chapter 7. Positrons: Their Potential Role in Radionuclide Therapy

Part 4 – Dosimetry Formalisms

Chapter 8. Biokinetic Modelling For Radionuclide Dosimetry

Chapter 9. Standardized Tumor and Organ Dosimetry

Chapter 10. Image-based Dosimetry Procedures

Chapter 11. Combining External Beam Radiotherapy and Radionuclide Therapy

Chapter 12. Uncertainties in Dose Calculations

Part 5 – Safety

Chapter 13. Design, Shielding, and Operational Radiation Safety Aspects of the Radiotheranostic Facility

Chapter 14. Management of Deceased Patients Under Treatment (Radioactive Cadavers)

Chapter 15. Radiopharmaceutical Regulatory Requirements

Part 6 – Future Directions and Opportunities

Chapter 16. The Economics of Theranostics

Chapter 17. Artificial intelligence in Radiotheranostics

Über Autor(innen)

Cari (Caridad) Borrás is a medical physicist in Washington DC, where she works as an international consultant and lecturer, and has an adjunct faculty position at the George Washington University School of Medicine and Health Sciences. She holds a Doctor of Science (Physics) degree from the Universitat de Barcelona, Catalonia, Spain. The research for her doctoral thesis –on the dosimetry and the radiation effects of Astatine-211 on the development of the rat embryo– was performed at Thomas Jefferson University in Philadelphia PA, USA, under a Fulbright scholarship (1966-1973). She is certified in Radiological Physics by the American Board of Radiology (ABR) and in Medical Health Physics by the American Board of Medical Physics and keeps both certifications current. She worked as a radiological physicist at the West Coast Cancer Foundation in San Francisco CA (1974-1988), directed the Radiological Health Program of the Pan American / World Health Organization in Washington DC (1988-2003), joined as Senior Scientist and Director of Special Programs the Institute for Radiological Image
Sciences, Inc. in Frederick MD (2003-2004), and was a Visiting Professor at the Universidade Federal de Pernambuco in Recife, Brazil, where she supervised graduated students in medical radiation dosimetry (2009-2011). She is a member of the American Association of Physicists in Medicine (AAPM), American College of Radiology (ACR), Health Physics Society (HPS), Society of Nuclear Medicine and Molecular Imaging, and the Spanish Medical Physics (SEFM) and Radiation Protection (SEPR) Societies. She has served on numerous committees of these societies as well as the International Organization for Medical Physics (IOMP), where she chaired the Science Committee (2000-2009); the International Union for Physical and Engineering Sciences in Medicine
(IUPESM), where she co-chaired/chaired the Health Technology Task Group (2009-2015), and the European Federation of Organisations for Medical Physics, where she currently is a member of the Scientific Committee. She has lectured in more than 300 courses/congresses, many of which she organized; authored around 100 publications, among them five book chapters, and has edited two books. She is a Fellow of ACR, AAPM, IOMP, HPS and IUPESM, and has been given awards by SEFM, AAPM, IOMP, Latin American Medical Physics Association, American College of Clinical Engineering, ACR and ABR.